Uridylate-specific_endoribonuclease Google Drive Data

Uridylate-specific endoribonuclease (NendoU) (nsp 15)– NendoU cleaves 2′-3′-cyclic phosphates 5′, and it is Mn²⁺-dependent.² The functionally active form of the endoribonuclease is a hexamer. The SARS-CoV-2 NendoU protein structure is homologous to SARS-CoV and MERS-CoV. SARS-CoV NendoU inhibitors have good chance of inhibiting the SARS-CoV-2 homolog but inhibitors of MERS-CoV NendoU are unlikely to be effective.²⁵ Based on an in silico study, 2-deoxy-D-glucose can inactivate 3CL^pro and nsp15 endoribonuclease.¹¹ One study suggests that the inhaled corticosteroid ciclesonide targets NendoU and blocks coronavirus RNA replication.²⁶

Uridylate-specific endoribonuclease 2,489 Sequences

Amino Acid	AA	AA	Conservation	Conservation Z-score	RMSD_CA	RMSF[A]	Secondary Structure	DCCM >0.9
6453	S	SER	48.97549217	0.058285975	1.552	1.592	H	0
6454	L	LEU	82.64363198	1.015679007	1.29	1.689	H	0
6455	E	GLU	82.44274809	1.009966638	1.324	1.355	H	2
6456	N	ASN	98.553636	1.468098625	1.287	1.136	H	4
6457	V	VAL	28.96745681	-0.51066597	1.032	1.042	H	1
6458	A	ALA	82.9650462	1.024818797	1.134	1.068	H	1
6459	F	PHE	52.59140217	0.161108615	1.293	1.295	H	2
6460	N	ASN	99.23664122	1.48752068	1.191	1.023	H	1
6461	V	VAL	61.55082362	0.415880269	1.283	1.08	H	1
6462	V	VAL	73.16191241	0.746055193	1.639	1.488	H	2
6463	N	ASN	12.97709924	-0.965370537	1.861	1.757	H	2
6464	K	LYS	48.85496183	0.054858553	2.529	1.911	H	1
6465	G	GLY	94.29489755	1.346996404	2.508	1.161	C	0
6466	H	HIS	57.05102451	0.287923205	1.376	1.153	C	0
6467	F	PHE	64.28284452	0.493568487	1.102	0.978	C	0
6468	D	ASP	28.68621937	-0.518663287	1.49	1.385	C	0
6469	G	GLY	73.3627963	0.751767562	1.277	1.328	C	0
6470	Q	GLN	15.66894335	-0.888824793	1.799	1.741	C	1
6471	Q	GLN	2.531137003	-1.262413721	1.809	2.303	C	2
6472	G	GLY	98.99558055	1.480665837	1.786	1.479	C	3
6473	E	GLU	89.11209321	1.199617286	1.645	1.604	C	4
6474	V	VAL	3.013258337	-1.248704035	1.737	1.504	C	2
6475	P	PRO	94.61631177	1.356136194	1.844	1.717	E	1
6476	V	VAL	62.35435918	0.438729745	1.485	1.777	E	0
6477	S	SER	8.276416231	-1.099039969	1.723	1.544	E	0
6478	I	ILE	46.24347127	-0.019402243	1.572	1.446	E	1
6479	I	ILE	24.18642025	-0.646620351	1.855	1.787	E	2
6480	N	ASN	71.71554841	0.704926137	2.451	1.905	T	2
6481	N	ASN	12.93692246	-0.96651301	1.673	1.536	T	1
6482	T	THR	2.531137003	-1.262413721	1.785	1.336	E	1
6483	V	VAL	77.50100442	0.869442362	1.636	1.152	E	2
6484	Y	TYR	13.74045802	-0.943663535	1.755	1.443	E	2
6485	T	THR	30.89594215	-0.455827229	1.792	1.459	E	2
6486	K	LYS	45.56046605	-0.038824297	1.874	2.388	E	1
6487	V	VAL	12.81639213	-0.969940432	2.099	2.528	E	1
6488	D	ASP	24.70871836	-0.631768191	3.193	3.013	T	1
6489	G	GLY	25.9140217	-0.597493978	2.874	2.6	T	0
6490	V	VAL	40.13660104	-0.193058258	2.325	2.735	E	1
6491	D	ASP	78.10365609	0.886579469	2.111	2.069	E	1
6492	V	VAL	27.76215348	-0.544940184	1.639	2.054	E	1
6493	E	GLU	8.356769787	-1.096755022	1.509	1.859	E	2
6494	L	LEU	8.356769787	-1.096755022	1.618	1.485	E	2
6495	F	PHE	99.11611089	1.484093258	1.534	0.978	E	1
6496	E	GLU	25.47207714	-0.610061189	1.593	1.434	C	1
6497	N	ASN	99.23664122	1.48752068	1.518	1.077	C	1
6498	K	LYS	60.26516673	0.379321108	2.207	1.984	C	0
6499	T	THR	98.915227	1.478380889	1.887	1.562	C	0
6500	T	THR	54.47971073	0.214804883	1.966	1.729	C	0
6501	L	LEU	84.17034954	1.05909301	1.465	1.378	C	0
6502	P	PRO	99.07593411	1.482950785	1.229	1.178	H	0
6503	V	VAL	12.97709924	-0.965370537	1.128	1.45	H	0
6504	N	ASN	77.86259542	0.879724626	1.331	1.376	H	0
6505	V	VAL	76.89835275	0.852305255	0.965	1.053	H	0
6506	A	ALA	99.276818	1.488663153	1.023	0.879	H	0
6507	F	PHE	84.4114102	1.065947853	1.016	0.764	H	0
6508	E	GLU	99.31699478	1.489805627	0.875	0.737	H	0
6509	L	LEU	94.41542788	1.350423825	0.99	1.097	H	0
6510	W	TRP	9.160305344	-1.073905546	1.013	0.813	H	0
6511	A	ALA	92.64764966	1.300154979	1.021	0.804	H	0
6512	K	LYS	93.93330655	1.33671414	0.911	0.779	E	0
6513	R	ARG	99.11611089	1.484093258	1.263	1.132	E	0
6514	N	ASN	25.5524307	-0.607776242	1.309	1.395	E	0
6515	I	ILE	34.83326637	-0.343864798	1.422	1.335	C	0
6516	K	LYS	9.200482121	-1.072763072	0.927	1.569	C	0
6517	P	PRO	9.6022499	-1.061338335	1.429	1.033	C	0
6518	V	VAL	9.079951788	-1.076190494	1.787	1.075	E	0
6519	P	PRO	99.31699478	1.489805627	1.202	0.793	C	0
6520	E	GLU	24.10606669	-0.648905298	1.085	0.709	H	0
6521	V	VAL	3.173965448	-1.24413414	1.517	0.878	H	0
6522	K	LYS	40.2169546	-0.19077331	1.538	0.934	H	0
6523	I	ILE	61.91241462	0.426162533	1.213	0.97	H	0
6524	L	LEU	86.58095621	1.127641437	1.607	0.869	H	0
6525	N	ASN	8.316593009	-1.097897496	1.826	0.747	H	0
6526	N	ASN	77.70188831	0.875154731	1.483	0.647	H	0
6527	L	LEU	98.15186822	1.456673887	1.526	0.865	H	0
6528	G	GLY	66.81398152	0.565544335	1.837	0.689	C	0
6529	V	VAL	69.58617919	0.644375026	1.498	0.839	C	0
6530	D	ASP	56.85014062	0.282210837	1.546	0.762	C	0
6531	I	ILE	26.03455203	-0.594066556	1.493	0.863	E	0
6532	A	ALA	8.798714343	-1.08418781	1.639	0.83	E	0
6533	A	ALA	8.597830454	-1.089900179	1.93	1.15	E	0
6534	N	ASN	15.14664524	-0.903676952	1.803	1.292	C	0
6535	T	THR	7.995178787	-1.107037286	1.13	0.978	C	0
6536	V	VAL	93.12977099	1.313864664	1.621	1.229	E	0
6537	I	ILE	58.61791884	0.332479683	2.17	1.32	E	0
6538	W	TRP	99.35717155	1.490948101	1.618	0.863	E	0
6539	D	ASP	94.73684211	1.359563616	1.056	0.734	E	0
6540	Y	TYR	93.81277622	1.333286719	1.185	1.608	C	0
6541	K	LYS	8.276416231	-1.099039969	1.281	1.417	C	0
6542	R	ARG	37.00281237	-0.282171213	1.35	1.571	C	0
6543	D	ASP	7.75411812	-1.113892129	1.208	1.021	E	0
6544	A	ALA	9.642426677	-1.060195861	1.106	0.879	E	0
6545	P	PRO	63.07754118	0.459294273	1.668	0.843	E	0
6546	A	ALA	8.557653676	-1.091042653	2.535	1.049	C	0
6547	H	HIS	8.155885898	-1.102467391	3.101	1.088	C	0
6548	I	ILE	2.531137003	-1.262413721	2.73	1.671	C	0
6549	S	SER	12.4949779	-0.979080222	1.459	1.021	C	0
6550	T	THR	99.15628767	1.485235732	1.132	0.777	E	0
6551	I	ILE	30.01205303	-0.480961652	1.285	0.961	C	0
6552	G	GLY	39.45359582	-0.212480312	1.842	0.834	C	0
6553	V	VAL	97.42868622	1.436109359	1.676	1.037	C	0
6554	C	CYS	94.49578144	1.352708773	1.775	0.964	T	0
6555	S	SER	6.227400562	-1.157306132	1.851	1.454	T	0
6556	M	MET	8.396946565	-1.095612548	1.914	1.945	T	0
6557	T	THR	99.15628767	1.485235732	1.199	0.948	E	0
6558	D	ASP	99.43752511	1.493233049	1.127	0.837	E	0
6559	I	ILE	46.64523905	-0.007977505	1.246	1.541	E	0
6560	A	ALA	9.803133789	-1.055625966	1.414	1.057	C	0
6561	K	LYS	8.838891121	-1.083045336	1.431	2.077	C	0
6562	K	LYS	8.67818401	-1.087615232	1.478	1.922	C	0
6563	P	PRO	9.200482121	-1.072763072	1.403	1.007	C	0
6564	T	THR	8.396946565	-1.095612548	1.524	1.339	C	0
6565	E	GLU	8.396946565	-1.095612548	1.662	1.394	C	0
6566	T	THR	2.410606669	-1.265841142	2.2	1.586	G	0
6567	I	ILE	2.450783447	-1.264698668	2.528	1.678	G	0
6568	C	CYS	8.477300121	-1.093327601	2.038	1.133	G	0
6569	A	ALA	2.490960225	-1.263556194	1.68	1.074	G	0
6570	P	PRO	2.77219767	-1.255558878	1.246	1.102	C	0
6571	L	LEU	42.34632382	-0.1302222	1.385	1.108	C	0
6572	T	THR	10.08437123	-1.047628649	1.659	0.799	E	0
6573	V	VAL	47.48895139	0.016014445	1.39	0.825	E	0
6574	F	PHE	2.571313781	-1.261271247	1.097	0.723	E	0
6575	F	PHE	71.83607875	0.708353558	1.383	0.669	E	0
6576	D	ASP	99.43752511	1.493233049	1.456	0.891	T	0
6577	G	GLY	24.42748092	-0.639765508	1.658	0.969	T	0
6578	R	ARG	62.51506629	0.44329964	1.664	1.75	T	0
6579	V	VAL	11.0486139	-1.020209278	1.775	1.228	T	0
6580	D	ASP	2.531137003	-1.262413721	2.126	1.642	C	0
6581	G	GLY	93.69224588	1.329859297	1.943	1.165	H	0
6582	Q	GLN	8.396946565	-1.095612548	1.77	1.219	H	0
6583	V	VAL	8.316593009	-1.097897496	1.731	1.374	H	1
6584	D	ASP	8.437123343	-1.094470074	2.117	1.124	H	1
6585	L	LEU	8.11570912	-1.103609865	1.808	1.264	H	0
6586	F	PHE	99.55805544	1.49666047	1.78	0.772	H	0
6587	R	ARG	11.16914423	-1.016781857	2.16	1.482	H	0
6588	N	ASN	9.200482121	-1.072763072	2.242	1.476	C	0
6589	A	ALA	29.04781037	-0.508381023	1.716	1.057	C	0
6590	R	ARG	14.10204902	-0.933381271	1.885	1.872	C	0
6591	N	ASN	92.76817999	1.3035824	1.553	0.822	E	0
6592	G	GLY	26.79791081	-0.572359555	1.527	0.607	E	0
6593	V	VAL	82.6034552	1.014536533	1.337	0.792	E	0
6594	L	LEU	63.84089996	0.481001275	1.182	0.811	E	0
6595	I	ILE	50.22097228	0.093702662	1.147	0.872	E	0
6596	T	THR	12.81639213	-0.969940432	1.387	0.88	E	0
6597	E	GLU	8.437123343	-1.094470074	1.5	1.422	C	0
6598	G	GLY	8.557653676	-1.091042653	1.644	1.178	C	0
6599	S	SER	8.597830454	-1.089900179	1.06	1.369	C	0
6600	V	VAL	55.76536762	0.251364044	1.057	1.214	C	0
6601	K	LYS	97.22780233	1.43039699	2.137	2.478	C	0
6602	G	GLY	13.37886701	-0.953945799	3.428	1.503	C	0
6603	L	LEU	23.58376858	-0.663757457	2.947	1.355	C	0
6604	Q	GLN	2.732020892	-1.256701352	3.052	2.113	C	0
6605	P	PRO	8.316593009	-1.097897496	3.864	1.673	C	0
6606	S	SER	10.76737646	-1.028206595	2.619	1.163	E	0
6607	V	VAL	18.20008035	-0.816848945	1.925	1.3	C	0
6608	G	GLY	39.97589393	-0.197628153	1.796	0.741	C	0
6609	P	PRO	43.02932905	-0.110800145	1.551	0.86	C	0
6610	K	LYS	2.531137003	-1.262413721	1.58	1.759	C	0
6611	Q	GLN	8.396946565	-1.095612548	1.25	0.953	C	0
6612	A	ALA	39.81518682	-0.202198048	1.043	0.896	E	0
6613	S	SER	9.843310566	-1.054483492	1.141	0.89	E	0
6614	L	LEU	17.59742869	-0.833986051	1.014	1.72	E	0
6615	N	ASN	53.19405384	0.178245722	1.349	1.61	T	0
6616	G	GLY	39.97589393	-0.197628153	1.931	1.656	T	0
6617	V	VAL	23.34270791	-0.6706123	1.305	1.631	E	0
6618	T	THR	12.8565689	-0.968797958	0.941	1.08	E	0
6619	L	LEU	12.69586179	-0.973367853	1.274	1.745	E	0
6620	I	ILE	8.276416231	-1.099039969	1.187	1.183	C	0
6621	G	GLY	29.36922459	-0.499241232	1.828	1.308	C	0
6622	E	GLU	8.316593009	-1.097897496	2.459	2.859	C	0
6623	A	ALA	2.450783447	-1.264698668	2.549	1.912	C	0
6624	V	VAL	50.42185617	0.099415031	2.365	1.853	C	0
6625	K	LYS	24.06588992	-0.650047772	2.419	2.029	C	0
6626	T	THR	9.441542788	-1.06590823	1.79	0.908	C	0
6627	Q	GLN	24.34712736	-0.642050455	1.544	1.537	C	0
6628	F	PHE	9.160305344	-1.073905546	1.507	0.835	C	0
6629	N	ASN	24.78907192	-0.629483244	1.284	0.828	E	0
6630	Y	TYR	20.73121736	-0.744873096	1.119	0.603	E	0
6631	Y	TYR	2.490960225	-1.263556194	1.287	0.771	E	0
6632	K	LYS	8.67818401	-1.087615232	1.46	0.923	E	0
6633	K	LYS	8.316593009	-1.097897496	1.717	1.054	E	0
6634	V	VAL	47.04700683	0.003447233	1.984	1.193	E	0
6635	D	ASP	15.18682202	-0.902534478	2.269	1.268	T	0
6636	G	GLY	78.06347931	0.885436995	2.261	1.024	T	0
6637	V	VAL	3.736440337	-1.228139507	2.462	1.299	E	0
6638	V	VAL	2.531137003	-1.262413721	1.892	1.101	E	0
6639	Q	GLN	10.88790679	-1.024779173	1.935	1.397	C	0
6640	Q	GLN	9.562073122	-1.062480808	1.124	1.781	C	0
6641	L	LEU	25.27119325	-0.615773558	0.921	1.005	C	0
6642	P	PRO	48.33266372	0.040006394	1.094	0.928	C	0
6643	E	GLU	24.78907192	-0.629483244	1.43	1.488	C	0
6644	T	THR	44.79710727	-0.060531299	1.209	0.758	C	0
6645	Y	TYR	39.57412616	-0.209052891	1.161	0.712	C	0
6646	F	PHE	48.93531539	0.057143501	1.161	0.715	C	0
6647	T	THR	98.192045	1.457816361	0.998	0.797	C	0
6648	Q	GLN	98.03133789	1.453246466	0.924	0.717	C	0
6649	S	SER	39.93571716	-0.198770627	0.768	0.771	C	0
6650	R	ARG	99.87946967	1.50580026	0.926	0.668	C	0
6651	N	ASN	22.90076336	-0.683179512	1.822	1.271	T	0
6652	L	LEU	17.59742869	-0.833986051	1.138	1.161	T	0
6653	Q	GLN	4.740859783	-1.199577663	1.764	1.458	T	0
6654	E	GLU	3.374849337	-1.238421771	2.771	1.331	T	0
6655	F	PHE	99.91964644	1.506942734	1.287	0.815	C	0
6656	K	LYS	14.3029329	-0.927668902	1.467	1.829	C	0
6657	P	PRO	87.06307754	1.141351123	1.194	0.876	C	0
6658	R	ARG	77.42065086	0.867157414	1.317	0.896	C	0
6659	S	SER	82.64363198	1.015679007	1.301	1.028	H	0
6660	Q	GLN	10.76737646	-1.028206595	1.557	1.814	H	1
6661	M	MET	81.07673765	0.971122529	1.24	0.96	H	2
6662	E	GLU	99.87946967	1.50580026	1.124	0.725	H	2
6663	I	ILE	2.973081559	-1.249846509	1.567	1.097	H	2
6664	D	ASP	98.23222178	1.458958835	1.582	0.909	H	2
6665	F	PHE	99.83929289	1.504657786	1.412	0.756	H	1
6666	L	LEU	84.53194054	1.069375274	1.64	1.179	H	0
6667	E	GLU	14.82523102	-0.912816742	1.729	1.534	H	0
6668	L	LEU	26.11490558	-0.591781609	1.583	1.202	C	1
6669	A	ALA	8.597830454	-1.089900179	1.73	1.194	H	2
6670	M	MET	35.47609482	-0.325585217	1.824	1.296	H	1
6671	D	ASP	41.14102049	-0.164496413	1.822	1.367	H	1
6672	E	GLU	9.03977501	-1.077332968	1.725	1.339	H	2
6673	F	PHE	99.87946967	1.50580026	1.566	0.839	H	2
6674	I	ILE	91.00040177	1.253313554	1.787	1.164	H	2
6675	E	GLU	18.80273202	-0.799711838	1.94	1.374	H	2
6676	R	ARG	8.959421454	-1.079617915	1.78	1.404	H	2
6677	Y	TYR	98.15186822	1.456673887	1.705	0.975	H	2
6678	K	LYS	9.120128566	-1.07504802	1.751	1.749	C	1
6679	L	LEU	83.00522298	1.025961271	1.744	1.036	T	0
6680	E	GLU	75.7332262	0.819173515	1.937	1.789	T	0
6681	G	GLY	9.481719566	-1.064765756	1.131	0.94	T	0
6682	Y	TYR	70.55042186	0.671794397	0.915	1.311	T	0
6683	A	ALA	42.3865006	-0.129079726	1.089	0.928	H	0
6684	F	PHE	77.62153475	0.872869783	0.806	1.403	H	0
6685	E	GLU	81.63921254	0.987117162	1.118	1.317	H	0
6686	H	HIS	99.83929289	1.504657786	1.18	1.126	H	0
6687	I	ILE	46.00241061	-0.026257085	0.918	1.071	H	0
6688	V	VAL	77.74206509	0.876297205	0.783	0.792	H	0
6689	Y	TYR	94.09401366	1.341284035	0.889	0.866	C	0
6690	G	GLY	99.91964644	1.506942734	0.955	0.695	C	0
6691	D	ASP	67.33627963	0.580396494	1.488	1.042	C	0
6692	F	PHE	42.06508638	-0.138219516	1.605	1.813	C	1
6693	S	SER	66.93451185	0.568971757	1.66	1.37	C	1
6694	H	HIS	26.35596625	-0.584926766	1.845	1.795	C	1
6695	S	SER	2.892728003	-1.252131457	1.68	1.577	C	1
6696	Q	GLN	24.94977903	-0.624913349	1.483	1.976	C	0
6697	L	LEU	73.84491764	0.765477248	1.314	1.451	C	0
6698	G	GLY	99.87946967	1.50580026	1.224	0.865	C	0
6699	G	GLY	99.91964644	1.506942734	0.827	0.754	C	0
6700	L	LEU	90.15668943	1.229321604	0.819	0.922	C	0
6701	H	HIS	99.87946967	1.50580026	0.808	0.892	C	0
6702	L	LEU	78.78666131	0.906001523	0.73	1.154	C	0
6703	L	LEU	76.97870631	0.854590203	0.757	0.828	H	0
6704	I	ILE	99.71876256	1.501230365	0.937	0.888	H	0
6705	G	GLY	58.3366814	0.324482367	1.147	0.601	H	0
6706	L	LEU	45.64081961	-0.036539349	0.986	1.146	H	0
6707	A	ALA	10.36560868	-1.039631333	0.806	0.886	H	0
6708	K	LYS	29.65046203	-0.491243916	1.324	1.178	H	0
6709	R	ARG	24.30695058	-0.643192929	1.158	0.823	H	0
6710	F	PHE	2.450783447	-1.264698668	0.873	1.277	H	0
6711	K	LYS	17.71795902	-0.83055863	1.413	1.979	H	0
6712	E	GLU	24.82924869	-0.62834077	1.877	1.55	C	0
6713	S	SER	23.70429892	-0.660330036	1.722	1.237	C	0
6714	P	PRO	7.794294898	-1.112749655	1.785	1.515	E	0
6715	F	PHE	2.732020892	-1.256701352	1.939	1.483	E	0
6716	E	GLU	3.013258337	-1.248704035	1.877	1.712	E	0
6717	L	LEU	8.437123343	-1.094470074	1.818	1.677	E	0
6718	E	GLU	56.40819606	0.269643625	2.091	1.553	E	0
6719	D	ASP	8.356769787	-1.096755022	1.567	1.09	E	0
6720	F	PHE	23.50341503	-0.666042405	1.604	1.362	C	0
6721	I	ILE	9.40136601	-1.067050703	1.284	1.661	C	0
6722	P	PRO	9.441542788	-1.06590823	0.953	1.137	C	0
6723	M	MET	8.11570912	-1.103609865	0.835	1.3	C	0
6724	D	ASP	77.34029731	0.864872467	1.365	0.786	C	0
6725	S	SER	84.45158698	1.067090327	0.911	0.812	C	0
6726	T	THR	63.15789474	0.461579221	1.073	0.812	C	0
6727	V	VAL	27.28003214	-0.558649869	0.718	0.988	C	0
6728	K	LYS	41.3017276	-0.159926518	0.81	1.591	C	0
6729	N	ASN	25.5524307	-0.607776242	1.072	1.187	E	0
6730	Y	TYR	41.34190438	-0.158784044	1.395	0.906	E	0
6731	F	PHE	40.49819204	-0.182775994	1.897	1.887	E	0
6732	I	ILE	45.27922861	-0.046821613	1.728	1.1	E	1
6733	T	THR	77.34029731	0.864872467	1.839	1.512	E	2
6734	D	ASP	24.62836481	-0.634053139	2.427	1.377	E	1
6735	A	ALA	51.02450783	0.116552138	2.583	1.832	C	0
6736	Q	GLN	8.236239454	-1.100182443	2.684	2.09	C	0
6737	T	THR	26.35596625	-0.584926766	2.184	1.588	C	0
6738	G	GLY	40.33748493	-0.187345889	2.129	1.539	E	0
6739	S	SER	72.92085175	0.739200351	1.977	1.231	E	1
6740	S	SER	63.96143029	0.484428697	1.872	1.349	E	2
6741	K	LYS	99.67858578	1.500087891	2.083	1.333	E	1
6742	C	CYS	8.316593009	-1.097897496	2.029	1.332	C	0
6743	V	VAL	99.55805544	1.49666047	1.671	1.441	C	0
6744	C	CYS	99.75893933	1.502372839	1.778	1.13	E	0
6745	S	SER	26.95861792	-0.567789659	1.487	0.805	C	0
6746	V	VAL	62.3141824	0.437587271	0.65	0.817	C	0
6747	I	ILE	40.2169546	-0.19077331	0.836	1.034	C	0
6748	D	ASP	99.87946967	1.50580026	0.912	0.581	C	0
6749	L	LEU	76.53676175	0.842022991	0.966	0.988	C	0
6750	L	LEU	81.55885898	0.984832214	1.137	1.324	H	0
6751	L	LEU	99.75893933	1.502372839	1.096	0.789	H	0
6752	D	ASP	99.67858578	1.500087891	1.229	1.054	H	0
6753	D	ASP	99.71876256	1.501230365	1.157	0.648	H	0
6754	F	PHE	95.21896344	1.373273301	0.833	0.705	H	0
6755	V	VAL	78.14383286	0.887721943	1.049	0.887	H	0
6756	E	GLU	25.03013258	-0.622628401	1.441	1.033	H	0
6757	I	ILE	68.90317397	0.624952972	1.092	0.886	H	0
6758	I	ILE	16.87424669	-0.854550579	1.243	1.25	H	0
6759	K	LYS	78.42507031	0.895719259	1.598	1.645	H	0
6760	S	SER	70.59059863	0.672936871	1.818	1.097	H	0
6761	Q	GLN	25.79349136	-0.600921399	1.873	1.1	C	0
6762	D	ASP	63.92125352	0.483286223	2.515	1.442	C	0
6763	L	LEU	77.5411812	0.870584836	2.289	1.294	C	1
6764	S	SER	24.10606669	-0.648905298	2.827	1.363	C	2
6765	V	VAL	63.64001607	0.475288906	2.588	1.394	C	2
6766	V	VAL	70.34953797	0.666082028	2.537	1.525	E	2
6767	S	SER	99.71876256	1.501230365	2.28	1.229	E	2
6768	K	LYS	99.43752511	1.493233049	2.212	1.402	E	2
6769	V	VAL	99.55805544	1.49666047	1.891	1.449	E	1
6770	V	VAL	62.47488951	0.442157166	1.788	1.042	E	0
6771	K	LYS	25.43190036	-0.611203663	1.395	1.441	E	0
6772	V	VAL	95.98232222	1.394980303	1.048	1.221	E	0
6773	T	THR	8.597830454	-1.089900179	1.105	0.779	E	0
6774	I	ILE	53.87705906	0.197667776	0.939	0.759	E	0
6775	D	ASP	99.79911611	1.503515313	1.072	0.557	T	0
6776	Y	TYR	25.27119325	-0.615773558	1.109	0.659	T	0
6777	T	THR	19.52591402	-0.77914731	1.359	1.009	E	0
6778	E	GLU	8.437123343	-1.094470074	0.993	1.082	E	0
6779	I	ILE	44.11410205	-0.079953353	0.776	0.963	E	0
6780	S	SER	8.758537565	-1.085330284	1.303	1.04	E	0
6781	F	PHE	63.15789474	0.461579221	1.516	0.716	E	0
6782	M	MET	99.55805544	1.49666047	1.94	1.291	E	0
6783	L	LEU	83.00522298	1.025961271	1.917	1.043	E	1
6784	W	TRP	99.83929289	1.504657786	2.241	1.683	E	2
6785	C	CYS	78.30453998	0.892291838	2.443	1.081	E	2
6786	K	LYS	58.17597429	0.319912471	2.319	1.968	E	2
6787	D	ASP	77.66171153	0.874012257	2.399	1.607	T	2
6788	G	GLY	42.58738449	-0.123367357	2.381	1.297	T	2
6789	H	HIS	12.17356368	-0.988220012	2.277	1.568	E	2
6790	V	VAL	51.50662917	0.130261823	2.125	1.103	E	2
6791	E	GLU	8.396946565	-1.095612548	2.152	1.308	E	1
6792	T	THR	99.71876256	1.501230365	1.933	1.276	E	0
6793	F	PHE	78.6259542	0.901431628	1.58	0.838	E	0
6794	Y	TYR	99.638409	1.498945418	1.395	0.968	E	0
6795	P	PRO	99.55805544	1.49666047	1.385	0.966	E	0
6796	K	LYS	10.08437123	-1.047628649	2.385	2.563	C	0
6797	L	LEU	97.70992366	1.444106676	4.239	3.405	C	0
6798	Q	GLN	99.638409	1.498945418	6.687	6.048	C	0

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

11.         Balkrishna A, Thakur P, Singh S, et al. Glucose antimetabolite 2-Deoxy-D-Glucose and its derivative as promising candidates for tackling COVID-19: Insights derived from in silico docking and molecular simulations.

25.         Kim Y, Jedrzejczak R, Maltseva NI, et al. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2. bioRxiv 2020;2020.03.02.968388.

26.         Matsuyama S, Kawase M, Nao N, et al. The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15. bioRxiv 2020;2020.03.11.987016.