RNA-directed_RNA_polymerase Google Drive Data

Gray amino acids fall below the average conservation (value <0) for each protein, yellow = 0-0.5, light orange = 0.5-1, orange = 1-1.5, dark orange = 1.5-2, red = >2

RNA-directed RNA polymerase (RdRp) (nsp12)– involved with replication and transcription of the viral RNA genome.2 One study states that the active triphosphate forms of Sofosbuvir, Alovudine, AZT and Tenofovir alafenamide inhibit RdRp. Tenofovir and emtricitabine are the two components in DESCOVY and TRUVADA, medications for use as pre-exposure prophylaxis (PrEP) to prevent HIV infection. DESCOVY and TRUVADA have potential as PrEP for COVID-19.18 Another study points out that HCV and SARS-CoV-2 are both +ssRNA viruses containing RdRp. Beclabuvir, a non-nucleoside inhibitor of the RdRpHCV can efficiently bind to RdRp SARS-CoV-2.19 Other studies suggest that theaflavin could be a potential RdRp inhibitor for further study and remdesivir can potentially act as an RNA-chain terminator.20,21 One study states that these compounds show promise as well: 6-Shogaol, 6- Gingerol, Beta Sitosterol, Piperidine, Apigenin, Piperine, Quercetin, Alpha-Bisabolol, Andrographolide, Carvacrol, Cissamine, Costunolide , Cucurbitacin B ,Linoleic acid , Pellitorine, Rutin, Vetiverol and Cynaropicrin.22 Additionally, the nsp12-nsp7-nsp8 complex of SARS-CoV-2 is essential for viral replication and transcription and is a potential target to fight against the virus. Seven compounds (Saquinavir, Tipranavir, Lonafarnib, Tegobuvir, Olysio, Filibuvir, and Cepharanthine) were found to interact well with nsp12-nsp7-nsp8 indicating potential as drug candidates.14

Interaction of the RNA-dependent RNA polymerase (gray) with nsp7 (cyan) and nsp8

Dynamics Data for Interaction

RNA-directed RNA polymerase 5,086 Sequences

Amino AcidAAAAConservationConservation Z-scoreRMSD_CARMSF[A]Secondary StructureDCCM >0.9
4393SSER4.65985057-1.4178784245.8372.031H1
4394AALA4.227290602-1.4366737035.7941.764H2
4395DASP4.581203303-1.4212957484.7931.876H2
4396AALA4.286276052-1.434110714.2071.893H3
4397QGLN1.179709005-1.5690949814.2722.039H4
4398SSER1.199370822-1.568240653.6221.788H3
4399FPHE14.3138026-0.9984019882.5132.532H4
4400LLEU4.089657884-1.4426540182.6982.236H3
4401NASN4.109319701-1.4417996882.2921.754H4
4402RARG4.266614235-1.4349650411.8212.68H3
4403VVAL5.760912308-1.3700358982.1142.124H2
4404CCYS4.266614235-1.4349650412.7281.979H2
4405GGLY4.423908769-1.4281303942.4941.828G2
4406VVAL4.915454188-1.4067721242.6942.05G1
4407SSER4.325599685-1.4324020482.5232.263G0
4408AALA22.00157295-0.6643586353.4082.457G0
4409AALA21.25442391-0.6968232064.5652.661C0
4410RARG21.23476209-0.6976775374.8944.621C0
4411LLEU13.46834448-1.0351382144.73.771C0
4412TTHR4.266614235-1.4349650415.9044.241C0
4413PPRO21.37239481-0.6916972219.0434.755C1
4414CCYS21.21510028-0.69853186811.1274.552C2
4415GGLY4.345261502-1.43154771811.8074.984C2
4416TTHR4.423908769-1.42813039412.2216.263C3
4417GGLY39.657884390.10283044812.086.069C3
4418TTHR21.62799843-0.6805909215.3416.582C2
4419SSER19.74046402-0.7626066816.2977.779C4
4420TTHR33.58238301-0.16115777716.1236.692C2
4421DASP27.09398348-0.4430869516.9586.351C2
4422VVAL21.56901298-0.68315391316.8416.035C2
4423VVAL27.78214707-0.41318537116.2636.404C3
4424YTYR15.45418797-0.948850817.1017.101C3
4425RARG39.854502560.11137375714.0167.094C6
4426AALA39.854502560.11137375715.2867.619C4
4427FPHE40.070782540.12077139616.6148.964C3
4428DASP40.110106170.12248005717.3087.919C5
4429IILE37.18049548-0.00481523615.5728.605C3
4430YTYR26.60243807-0.46444522113.9016.907C3
4431NASN5.662603225-1.37430755214.7447.871H5
4432DASP1.219032639-1.56738631915.1328.58H5
4433KLYS12.66220999-1.07016577816.8839.057H8
4434VVAL19.8387731-0.75833502615.0696.95H8
4435AALA21.70664569-0.67717359713.2816.817H8
4436GGLY38.871411720.06865721513.9747.404H8
4437FPHE4.856468738-1.40933511614.137.234H10
4438AALA4.561541486-1.42215007912.4665.868H9
4439KLYS12.95713724-1.05735081511.8317.06H10
4440FPHE4.305937869-1.43325637912.4737.739H8
4441LLEU10.73535195-1.15389019911.9976.367H9
4442KLYS21.68698388-0.67802792810.5765.508H10
4443TTHR13.01612269-1.05478782310.6347.068H8
4444NASN21.68698388-0.67802792811.1377.321H6
4445CCYS13.01612269-1.0547878239.8615.949H5
4446CCYS21.64766024-0.679736598.7926.121H6
4447RARG23.73181282-0.5891775228.3664.49C3
4448FPHE21.58867479-0.68229958210.2965.067C2
4449QGLN12.99646087-1.05564215410.2495.959C2
4450EGLU12.93747542-1.0582051469.7095.371C3
4451KLYS4.404246952-1.42898472511.517.784C3
4452DASP28.84388517-0.36705150711.8987.992C7
4453EGLU12.24931184-1.0881067259.9118.307T9
4454DASP4.011010617-1.44607134210.1967.989T11
4455DASP1.337003539-1.56226033411.7149.985T7
4456NASN6.311443177-1.34611463512.78810.4T10
4457LLEU6.626032245-1.33244534212.5758.994C15
4458IILE1.57294534-1.55200836412.4359.42C15
4459DASP48.820290990.50094861413.711.533C10
4460SSER21.31340936-0.69426021415.68312.798C10
4461YTYR27.13330712-0.44137828916.44112.145C10
4462FPHE35.13566654-0.09366564215.50513.056C10
4463VVAL46.814785690.4138068714.78311.138C7
4464VVAL45.792371220.36938166711.6559.046C7
4465KLYS50.747149040.58467303511.57210.641C10
4466RARG39.402280770.0917241489.3477.139C9
4467HHIS13.15375541-1.0488075078.0956.902C6
4468TTHR37.632717260.0148343736.8235.722C3
4469FPHE1.179709005-1.5690949815.765.442C1
4470SSER29.74832875-0.3277522895.3264.333H2
4471NASN21.58867479-0.6822995826.7636.24H3
4472YTYR29.88596146-0.3217719737.0685.986H1
4473QGLN4.423908769-1.4281303946.0014.679H2
4474HHIS30.96736138-0.2747837776.2316.284H5
4475EGLU51.592607160.6214092617.0576.653H5
4476EGLU6.783326779-1.3256106956.9135.442H2
4477TTHR5.210381439-1.3939571616.7395.511H6
4478IILE17.40070783-0.8642720487.2766.936H6
4479YTYR50.963429020.5940706747.5756.915H5
4480NASN12.44593-1.0795634177.766.232H6
4481LLEU18.71804955-0.8070318838.187.021H7
4482LLEU38.163586320.0379013058.5237.402H9
4483KLYS27.42823437-0.4285633268.6897.476H7
4484DASP23.20094377-0.6122444549.1867.741H5
4485CCYS35.52890287-0.0765790259.8027.923H7
4486PPRO4.423908769-1.42813039410.5468.741C7
4487AALA31.04600865-0.27136645410.6618.847C6
4488VVAL37.809673610.02252335110.0868.546C6
4489AALA41.230829730.1711769158.4158.86T6
4490KLYS3.558788832-1.4657209518.8049.72T6
4491HHIS41.211167910.1703225848.6559.656T5
4492DASP39.933149820.114791089.598.746T7
4493FPHE51.376327170.61201162210.8158.805C6
4494FPHE41.132520640.166905269.9489.187C5
4495KLYS5.131734172-1.39737448512.79210.162C3
4496FPHE22.70939835-0.63360272515.3649.45C2
4497RARG4.463232403-1.42642173315.7599.316C3
4498IILE2.457727094-1.51356347713.2877.304C2
4499DASP14.51042076-0.9898586816.6188.263C4
4500GGLY13.56665356-1.0308665614.4147.31C3
4501DASP6.488399528-1.33842565711.4576.183C4
4502MMET5.053086905-1.40079180812.5267.146C4
4503VVAL13.27172631-1.04368152210.1055.309C3
4504PPRO24.73456547-0.545606658.4734.849C5
4505HHIS22.532442-0.6412917025.7384.602G2
4506IILE32.06842312-0.2269412513.5153.509G3
4507SSER16.35863154-0.9095515824.8583.5G2
4508RARG51.749901690.6282439073.4643.973G1
4509QGLN27.7034998-0.4166026953.0152.777G1
4510RARG21.66732206-0.6788822594.1163.133C0
4511LLEU51.690916240.6256809153.9021.981C1
4512TTHR49.351160050.5240155463.8041.791C2
4513KLYS31.28195045-0.2611144843.3581.888C2
4514YTYR50.963429020.5940706742.9311.559C4
4515TTHR51.769563510.6290982382.9211.51C6
4516MMET49.469130950.5291415312.8841.678H8
4517AALA5.053086905-1.4007918082.5411.396H7
4518DASP51.749901690.6282439072.4851.381H8
4519LLEU44.042469520.2933462232.5381.471H6
4520VVAL16.10302792-0.9206578832.4081.36H8
4521YTYR49.115218250.5137635762.0351.263H7
4522AALA51.022414470.5966336671.8991.313H4
4523LLEU47.876523790.4599407341.7751.57H4
4524RARG51.749901690.6282439071.9271.078H4
4525HHIS32.85489579-0.1927680181.8241.149H3
4526FPHE49.52811640.5317045241.6241.228C2
4527DASP49.508454580.5308501932.2021.395T1
4528EGLU23.39756193-0.6037011462.3761.608T0
4529GGLY4.423908769-1.4281303942.1891.65T0
4530NASN23.27959103-0.6088271312.6972.142T0
4531CCYS41.801022410.1959525092.7031.496H1
4532DASP17.97090051-0.8394964542.8181.669H3
4533TTHR7.786079434-1.2820398232.7131.449H4
4534LLEU48.721981910.496676962.5261.449H4
4535KLYS41.447109710.1805745542.4191.642H7
4536EGLU22.27683838-0.6523980032.7291.56H7
4537IILE47.955171060.4633580582.7611.498H7
4538LLEU49.370821860.5248698772.7141.489H8
4539VVAL29.78765238-0.3260436272.91.831H8
4540TTHR15.15926072-0.9616657633.091.763H7
4541YTYR29.98427055-0.3175003193.1991.768H6
4542NASN4.345261502-1.4315477183.0342.161C6
4543CCYS17.61698781-0.8548744092.8961.548C6
4544CCYS41.466771530.1814288842.4551.656C3
4545DASP18.06920959-0.83522483.3251.976T2
4546DASP4.522217853-1.423858745.1892.545T2
4547DASP5.800235942-1.3683272363.4532.288T2
4548YTYR39.284309870.0865981633.1161.597T3
4549FPHE41.525756980.1839918773.0921.691C2
4550NASN15.06095163-0.9659374173.0942.14C3
4551KLYS13.44868266-1.0359925452.5352.338C1
4552KLYS48.604011010.4915509752.5552.627C0
4553DASP23.9480928-0.5797798832.431.508T0
4554WTRP51.749901690.6282439072.0381.489T1
4555YTYR25.65867086-0.5054531011.6061.242T2
4556DASP51.730239870.6273895762.0411.188T1
4557FPHE21.88360204-0.669484622.0911.317C0
4558VVAL40.640975230.145546992.5671.601C0
4559EGLU51.690916240.6256809153.3581.88C0
4560NASN51.671254420.6248265843.942.126C0
4561PPRO32.46165946-0.2098546342.7951.447C1
4562DASP30.2791978-0.3046853562.6711.489H2
4563IILE30.88871412-0.2782011012.1471.215H3
4564LLEU4.54187967-1.4230044092.0731.259H3
4565RARG21.21510028-0.6985318682.2962.675H4
4566VVAL40.129767990.1233343882.3511.335H6
4567YTYR41.388124260.1780115612.4651.089H4
4568AALA31.16397955-0.2662404692.6281.252H4
4569NASN4.463232403-1.4264217332.7221.487C3
4570LLEU43.668895010.2771139372.6221.677H0
4571GGLY51.749901690.6282439072.6421.164H1
4572EGLU13.95988989-1.0137799432.5081.369H3
4573RARG13.68462446-1.0257405752.652H5
4574VVAL39.127015340.0797635162.4991.334H5
4575RARG21.70664569-0.6771735972.3081.254H8
4576QGLN12.72119544-1.0676027852.291.498H8
4577AALA47.542272910.445417112.7421.442H8
4578LLEU22.6504129-0.6361657172.7911.393H8
4579LLEU44.573338580.3164131552.081.669H8
4580KLYS23.27959103-0.6088271312.3431.834H10
4581TTHR15.67046795-0.9394531613.1691.41H9
4582VVAL37.573731810.0122713812.6731.572H8
4583QGLN4.502556036-1.4247130711.8981.814H8
4584FPHE45.399134880.352295052.6171.8H8
4585CCYS31.97011404-0.2312129052.761.386H9
4586DASP41.683051510.1908265242.2781.468H8
4587AALA24.12504915-0.5720909052.3351.608H8
4588MMET39.048368070.0763461932.6491.746H11
4589RARG4.443570586-1.4272760632.5162.031H10
4590NASN1.199370822-1.568240652.371.915H7
4591AALA15.86708612-0.9309098532.2641.694C6
4592GGLY51.671254420.6248265842.0111.558E9
4593IILE17.12544239-0.876232682.3671.71E11
4594VVAL48.407392840.4830076672.6461.624E10
4595GGLY51.690916240.6256809152.4371.538E2
4596VVAL46.165945730.3856139521.9651.565E3
4597LLEU29.04050334-0.3585081982.6341.794E4
4598TTHR51.749901690.6282439072.7741.691C2
4599LLEU49.606763660.5351218472.7971.485C8
4600DASP51.710578060.6265352462.6271.648C2
4601NASN51.789225320.6299525693.1781.56E5
4602QGLN51.769563510.6290982383.1911.453E8
4603DASP51.730239870.6273895762.9681.594E1
4604LLEU51.553283520.6197005992.9532.269T0
4605NASN47.502949270.4437084494.4851.803T0
4606GGLY51.769563510.6290982384.591.878E0
4607NASN11.58081007-1.1171539733.7271.79E2
4608WTRP22.57176563-0.6395830413.7751.628E4
4609YTYR51.651592610.6239722533.4981.627C4
4610DASP51.769563510.6290982383.2591.825C1
4611FPHE51.769563510.6290982383.0622.494T0
4612GGLY51.789225320.6299525694.5472.235T0
4613DASP51.769563510.6290982384.7912.307T0
4614FPHE45.320487610.3488777273.0471.889T1
4615IILE4.954777821-1.4050634622.2162.009E5
4616QGLN5.780574125-1.3691815672.7422.111E4
4617TTHR25.06881636-0.5310830262.1151.884C6
4618TTHR1.63193079-1.5494453721.6351.851T2
4619PPRO38.340542670.0455902831.7631.889T1
4620GGLY49.980338180.5513541332.852.032T0
4621SSER9.14274479-1.2230909962.6221.909T0
4622GGLY51.966181680.6376415463.091.556C2
4623VVAL34.95871018-0.1013546192.861.886E6
4624PPRO29.23712151-0.349964892.9351.56E5
4625VVAL12.78018089-1.0650397932.7461.59E4
4626VVAL15.94573339-0.9274925292.771.474H5
4627DASP30.5151396-0.2944333862.7531.475H3
4628SSER43.334644120.2625903132.5411.49H1
4629YTYR51.789225320.6299525692.4471.419H5
4630YTYR51.474636260.6162832762.2721.201H6
4631SSER51.101061740.600050992.511.26H5
4632LLEU5.583955958-1.3777248762.8181.615H4
4633LLEU15.78843885-0.9343271762.8451.413C4
4634MMET51.749901690.6282439072.8011.296C3
4635PPRO51.749901690.6282439072.4471.094H2
4636IILE17.67597326-0.8523114172.1141.313H4
4637LLEU22.09988203-0.660086982.0921.175H6
4638TTHR14.56940621-0.9872956872.1151.071H5
4639LLEU5.957530476-1.361492592.2681.301H3
4640TTHR42.96106960.2463580272.2481.127H6
4641RARG3.794730633-1.4554689812.3251.859C4
4642AALA20.50727487-0.7292877782.2631.235C4
4643LLEU51.612268970.6222635912.1891.26C2
4644TTHR1.199370822-1.568240652.611.358G2
4645AALA13.78293354-1.021468922.6621.338G2
4646EGLU22.47345655-0.6438546952.4921.186G2
4647SSER4.54187967-1.4230044092.6541.28G2
4648HHIS13.68462446-1.0257405752.791.451T2
4649VVAL10.06685018-1.1829374472.6582.063T2
4650DASP16.16201337-0.918094893.1242.151T2
4651TTHR1.278018089-1.5648233273.842.089T2
4652DASP13.70428628-1.0248862443.9082.111T2
4653LLEU5.32835234-1.3888311763.1631.965T2
4654TTHR2.084152576-1.5297957633.0962.406T2
4655KLYS14.05819898-1.0095082892.7652.391T2
4656PPRO13.68462446-1.0257405752.2471.975C2
4657YTYR3.421156115-1.4717012672.1161.93C2
4658IILE12.87848997-1.0607681392.0881.489C1
4659KLYS4.699174204-1.4161697632.1842.41C0
4660WTRP13.76327173-1.0223232511.9231.527C0
4661DASP32.81557216-0.194476682.0861.817T0
4662LLEU49.075894610.5120549152.2512.396T0
4663LLEU24.32166732-0.5635475972.1342.231T0
4664KLYS7.786079434-1.2820398231.9032.189T0
4665YTYR41.742036960.1933895162.3652.363C1
4666DASP41.860007860.1985155012.2131.319C2
4667FPHE40.483680690.1387123431.7991.537H3
4668TTHR41.801022410.1959525092.361.271H3
4669EGLU29.21745969-0.3508192212.5861.837H3
4670EGLU4.71883602-1.4153154321.8891.375H5
4671RARG4.522217853-1.423858741.8191.002H3
4672LLEU14.68737711-0.9821697022.0291.696H5
4673KLYS5.348014157-1.3879768452.2181.882H8
4674LLEU41.624066060.1882635312.1161.287H6
4675FPHE43.629571370.2754052762.1351.192H7
4676DASP5.308690523-1.3896855072.1241.458H8
4677RARG4.423908769-1.4281303942.4581.772H6
4678YTYR41.860007860.1985155012.51.251H5
4679FPHE41.89933150.2002241631.9721.178T8
4680KLYS41.722375150.1925351851.6661.787T5
4681YTYR29.27644514-0.3482562281.8931.328T3
4682WTRP42.390876920.2215824331.8091.135T5
4683DASP17.28273692-0.8693980331.8821.452C2
4684QGLN25.32441998-0.5199767251.6211.478C4
4685TTHR16.26032245-0.9138232362.0341.243C7
4686YTYR49.862367280.5462281482.1661.072C9
4687HHIS51.867872590.6333698922.1471.081C8
4688PPRO43.944160440.2890745692.0441.11C5
4689NASN50.314589070.5658777571.9981.061T6
4690CCYS40.916240660.1575076211.8531.05T5
4691VVAL33.46441211-0.1662837622.1531.248T4
4692NASN13.15375541-1.0488075072.421.264T4
4693CCYS51.966181680.6376415462.1571.023C10
4694LLEU4.423908769-1.4281303941.8041.461C3
4695DASP48.800629180.5000942832.4771.287H5
4696DASP38.14392450.0370469752.4421.108H4
4697RARG32.87455761-0.1919136872.4321.476H5
4698CCYS51.946519860.6367872162.2631.013H12
4699IILE30.18088871-0.308957012.2381.051H10
4700LLEU18.34447503-0.8232641692.2761.069H5
4701HHIS51.926858040.6359328852.2851.011H5
4702CCYS51.985843490.6384958771.9450.932H10
4703AALA50.176956350.5598974411.9460.998H4
4704NASN51.926858040.6359328851.890.964H2
4705FPHE51.966181680.6376415461.9441.343H4
4706NASN51.985843490.6384958771.9490.967H4
4707VVAL19.42587495-0.7762759731.5841.136H2
4708LLEU52.477388910.6598541481.7891.186H3
4709FPHE51.907196220.6350785542.2491.097H2
4710SSER37.14117184-0.0065238982.3221.256H2
4711TTHR29.27644514-0.3482562282.2441.262C2
4712VVAL14.39244986-0.9949846652.4741.799C1
4713FPHE4.561541486-1.4221500792.2111.306C0
4714PPRO52.025167130.6402045392.1021.279T0
4715PPRO4.71883602-1.4153154322.4181.436T0
4716TTHR51.789225320.6299525692.2351.542T0
4717SSER14.23515533-1.0018193111.881.092T0
4718FPHE51.789225320.6299525691.7761.123C0
4719GGLY52.084152580.6427675311.8320.983E0
4720PPRO41.702713330.1916808541.7991.189E1
4721LLEU43.295320490.2608816511.4321.49E1
4722VVAL25.14746363-0.5276657021.4581.426E0
4723RARG48.780967360.4992399521.3852.269E1
4724KLYS40.719622490.1489643131.6642.429E2
4725IILE22.4144711-0.6464176872.2011.658E2
4726FPHE34.6244593-0.1158782432.1352.22E5
4727VVAL34.07392843-0.1397995072.0362.112E3
4728DASP52.064490760.64191322.0872.434T2
4729GGLY52.103814390.6436218622.5012.285T3
4730VVAL49.823043650.5445194862.1562.402E5
4731PPRO49.331498230.5231612152.032.156E3
4732FPHE30.81006685-0.2816184241.5042.287E3
4733VVAL42.449862370.2241454261.2111.713E1
4734VVAL24.53794731-0.5541499581.6251.326E1
4735SSER22.82736925-0.628476741.6211.179E2
4736TTHR5.505308691-1.3811421992.0881.391E2
4737GGLY52.044828940.641058871.9431.017E2
4738YTYR49.705072750.5393935011.9020.995E3
4739HHIS52.202123480.6478935161.8650.951E2
4740FPHE23.39756193-0.6037011461.7331.95E0
4741RARG4.935116005-1.4059177931.4811.078C0
4742EGLU33.50373575-0.1645751011.8931.032C1
4743LLEU52.280770740.651310841.7961.185C2
4744GGLY52.162799840.6461848551.8930.97E3
4745VVAL16.22099882-0.9155318981.9671.381E4
4746VVAL43.963822260.28992892.1311.506E2
4747HHIS5.033425088-1.4016461392.2321.377E2
4748NASN52.123476210.6444761932.481.126C3
4749QGLN15.31655525-0.9548311162.711.474C2
4750DASP52.752654350.6718147792.9151.447C1
4751VVAL29.41407786-0.3422759132.9552.172C0
4752NASN21.47070389-0.6874255672.2182.053C0
4753LLEU26.8777035-0.4524845892.8142.705C1
4754HHIS41.093197010.1651965992.8833.051C1
4755SSER20.27133307-0.7395397472.2932.179C1
4756SSER26.32717263-0.4764058532.2872.351C1
4757RARG38.596146280.0566965842.0193.076C0
4758LLEU41.879669680.1993698321.721.768C1
4759SSER35.74518285-0.0671813861.5371.534H2
4760FPHE4.856468738-1.4093351161.5161.608H2
4761KLYS22.09988203-0.660086981.4831.663H2
4762EGLU29.33543059-0.3456932361.3591.449H2
4763LLEU52.182461660.6470391851.3891.604H2
4764LLEU35.31262289-0.0859766641.1981.707H2
4765VVAL4.974439638-1.4042091311.2011.28H2
4766YTYR23.25992922-0.6096814621.1841.697H1
4767AALA22.80770743-0.6293310711.3881.21H0
4768AALA23.84978372-0.5840515371.4391.119H0
4769DASP52.772316160.672669111.5251.124C1
4770PPRO52.772316160.672669111.3291.196H1
4771AALA43.31498230.2617359821.4231.306H1
4772MMET14.86433346-0.9744807251.9111.697H2
4773HHIS23.27959103-0.6088271311.2171.087H1
4774AALA6.645694062-1.3315910111.2811.273H1
4775AALA41.171844280.1686139221.3431.496H2
4776SSER41.073535190.1643422681.3741.574H1
4777GGLY4.443570586-1.4272760631.2211.363H0
4778NASN21.62799843-0.680590921.5242.093E0
4779LLEU4.581203303-1.4212957482.4143.157E1
4780LLEU41.997640580.2044958172.5322.222C3
4781LLEU17.32206056-0.8676893724.625.188C2
4782DASP52.123476210.6444761934.3033.363T2
4783KLYS7.01926858-1.3153587253.2253.425T0
4784RARG52.143138030.6453305242.3022.428T0
4785TTHR52.103814390.6436218621.3651.261T0
4786TTHR4.404246952-1.4289847251.281.435C0
4787CCYS52.123476210.6444761931.1891.089C0
4788FPHE49.115218250.5137635761.661.7E0
4789SSER49.88202910.5470824791.181.105E0
4790VVAL46.342902080.393302931.0081.319E1
4791AALA43.806527720.2830942531.0791.22E2
4792AALA50.452221790.5718580731.0331.253E1
4793LLEU40.601651590.1438383281.3141.515C0
4794TTHR23.06331105-0.618224771.531.788C0
4795NASN4.443570586-1.4272760631.7942.467C0
4796NASN4.345261502-1.4315477181.8772.109C0
4797VVAL14.92331891-0.9719177322.1022.003C0
4798AALA6.272119544-1.3478232971.4651.495C0
4799FPHE22.63075108-0.6370200482.0981.707C0
4800QGLN52.143138030.6453305243.4051.674C0
4801TTHR48.171451040.4727556973.9011.947C0
4802VVAL51.651592610.6239722534.2782.011E0
4803KLYS42.823436890.2403777124.7442.806C0
4804PPRO52.143138030.6453305245.072.018C0
4805GGLY52.182461660.6470391854.9921.593C0
4806NASN22.09988203-0.660086983.8541.621C4
4807FPHE52.359418010.6547281633.1171.778C5
4808NASN52.143138030.6453305243.1161.609H8
4809KLYS30.00393236-0.3166459883.6992.517H8
4810DASP33.36610303-0.1705554164.0022.116H6
4811FPHE52.221785290.6487478473.4061.678H8
4812YTYR52.182461660.6470391853.5811.888H10
4813DASP45.969327570.3770706444.2562.146H9
4814FPHE49.233189150.5188895613.9521.9H9
4815AALA13.27172631-1.0436815223.6161.85H9
4816VVAL14.05819898-1.0095082894.2672.175H8
4817SSER25.04915454-0.5319373564.4562.266H8
4818KLYS22.25717656-0.6532523344.3252.666C7
4819GGLY49.921352730.548791144.4632.1C5
4820FPHE32.99252851-0.1867877023.7051.889C6
4821FPHE42.233582380.2147477873.7951.979C2
4822KLYS30.96736138-0.2747837774.0962.752T2
4823EGLU50.078647270.5556257874.7423.126T2
4824GGLY50.039323630.5539171255.2772.654T2
4825SSER50.412898150.5701494113.9482.268T1
4826SSER29.61069603-0.3337326043.3992.1C0
4827VVAL22.15886748-0.6575239882.6141.814C1
4828EGLU4.423908769-1.4281303942.5361.996C2
4829LLEU49.547778210.5325588552.331.674C2
4830KLYS49.429807310.527432872.0142.071C2
4831HHIS52.221785290.6487478471.7241.198C2
4832FPHE52.791977980.6735234411.9751.639E2
4833FPHE49.980338180.5513541332.3691.384C2
4834FPHE41.348800630.17630293.5371.65C2
4835AALA31.16397955-0.2662404693.0591.824C1
4836QGLN52.339756190.6538738322.311.556E0
4837DASP25.10813999-0.5293743642.3361.887T0
4838GGLY52.182461660.6470391852.7181.713T0
4839NASN29.66968148-0.3311696121.8251.913T0
4840AALA52.241447110.6496021781.3321.354T0
4841AALA52.674007080.6683974560.9631.129C0
4842IILE37.00353913-0.0125042130.8861.339C0
4843SSER4.954777821-1.4050634621.2121.295H0
4844DASP52.890287060.6777950951.2361.003H0
4845YTYR34.46716477-0.122712890.9740.943H0
4846DASP29.9252851-0.3200633110.8360.981H1
4847YTYR50.314589070.5658777571.2291.302H1
4848YTYR54.128981520.7316179371.1550.844T1
4849RARG34.8604011-0.1056262741.2971.474T2
4850YTYR52.634683440.6666887941.3361.054T2
4851NASN52.949272510.6803580881.5131.01T1
4852LLEU23.90876917-0.5814885441.5481.33C0
4853PPRO49.016909160.5094919221.8681.106C0
4854TTHR52.595359810.6649801332.0721.06C0
4855MMET36.09909556-0.0518034311.9511.173C0
4856CCYS13.72394809-1.0240319132.0060.975C1
4857DASP52.909948880.6786494262.210.961H2
4858IILE53.106567050.6871927342.5351.669H2
4859RARG12.48525364-1.0778547552.6251.369H2
4860QGLN50.137632720.5581887792.1331.17H4
4861LLEU22.59142745-0.638728712.2811.12H4
4862LLEU34.88006292-0.1047719432.8521.192H4
4863FPHE37.90798270.0267950052.3991.078H4
4864VVAL28.31301612-0.3901184392.1221.133H5
4865VVAL4.758159654-1.413606772.2461.142H4
4866EGLU34.58513567-0.1175869051.9151.041H3
4867VVAL38.753440820.063531232.0681.149H3
4868VVAL43.138025950.2540470052.0091.14H3
4869DASP9.20173024-1.2205280032.2181.14H2
4870KLYS37.21981911-0.0031065742.4911.628H3
4871YTYR55.328352340.7837321182.3731.093H2
4872FPHE53.086905230.6863384032.3341.11H3
4873DASP22.92567833-0.6242050862.5361.423H1
4874CCYS19.81911129-0.7591893562.3251.563C0
4875YTYR55.367675970.7854407792.3691.098C1
4876DASP27.50688164-0.4251460032.4841.679C1
4877GGLY55.367675970.7854407792.1081.258C0
4878GGLY55.485646870.7905667642.4231.235C0
4879CCYS55.446323240.7888581032.9121.251C1
4880IILE44.927251280.331791112.2471.618C2
4881NASN17.99056233-0.8386421231.641.285T2
4882AALA53.676759730.7119683281.571.325T3
4883NASN5.013763272-1.402500471.4691.44T2
4884QGLN23.45654738-0.6011381531.8681.696T3
4885VVAL55.446323240.7888581032.1051.46C1
4886IILE16.41761699-0.906988592.0181.849C0
4887VVAL55.406999610.7871494412.11.787C0
4888NASN28.48997247-0.3824294622.3172.177C0
4889NASN55.603617770.7956927492.322.236T0
4890LLEU43.138025950.2540470051.6721.597T1
4891DASP38.02595360.031920991.5411.499T2
4892KLYS55.505308690.7914210951.2911.861T1
4893SSER55.485646870.7905667641.6761.24C0
4894AALA55.387337790.786295111.8081.157C1
4895GGLY55.642941410.7974014111.5430.99C2
4896FPHE9.732599292-1.1974610711.411.148C2
4897PPRO55.682265040.7991100731.5131.138G2
4898FPHE36.09909556-0.0518034311.5311.107G2
4899NASN55.701926860.7999644041.4691.261G2
4900KLYS54.974439640.7683541631.5022.08G1
4901WTRP4.817145104-1.4110437781.6732.244C0
4902GGLY55.760912310.8025273961.6111.34C1
4903KLYS56.449075890.8324289751.6051.739C2
4904AALA55.682265040.7991100731.4931.289G2
4905RARG38.26189540.042172961.5241.558G2
4906LLEU43.963822260.28992891.461.823G2
4907YTYR55.171057810.7768974711.2831.253G2
4908YTYR56.881635860.8512242531.4951.307G2
4909DASP8.297286669-1.2598272211.6641.675C2
4910SSER32.02909949-0.2286499131.6111.493C1
4911MMET14.39244986-0.9949846651.5691.647C1
4912SSER44.750294930.3241021331.761.553H4
4913YTYR35.76484467-0.0663270551.541.653H4
4914EGLU43.43295320.2668619671.5761.851H4
4915DASP5.544632324-1.3794335371.8311.371H5
4916QGLN55.760912310.8025273961.7061.299H6
4917DASP52.732992530.6709604491.6431.203H5
4918AALA12.48525364-1.0778547551.6191.273H6
4919LLEU45.713723950.3659643431.651.267H3
4920FPHE31.26228864-0.2619688151.6480.989H4
4921AALA44.101454970.2959092151.7541.188H4
4922YTYR29.53204876-0.3371499282.0611.207H3
4923TTHR55.977192290.8119250352.211.038H2
4924KLYS56.213134090.8221770052.3371.283H2
4925RARG47.994494690.4650667192.5161.673C2
4926NASN56.075501380.8161966892.0711.053C3
4927VVAL40.149429810.1241887191.8351.152C2
4928IILE13.66496264-1.0265949051.7881.262C1
4929PPRO56.547384980.8367006291.2911.048C0
4930TTHR56.154148640.8196140131.3891.008C1
4931IILE15.27723162-0.9565397781.5511.252C2
4932TTHR57.884388520.8947951251.5661.14E2
4933QGLN56.311443180.8264486591.4941.334E1
4934MMET37.357451830.0028737421.4981.351E0
4935NASN56.350766810.8281573211.2021.203E0
4936LLEU56.252457730.8238856671.0451.214E0
4937KLYS58.356272120.9152990651.4131.362C0
4938YTYR56.547384980.8367006292.3721.314C0
4939AALA57.569799450.8811258321.4151.177C0
4940IILE57.117577660.8614762231.6291.34C0
4941SSER57.39284310.8734368551.7781.098E0
4942AALA36.68895006-0.0261735071.8881.372C0
4943KLYS59.064097520.9460549752.5192.018C0
4944NASN32.95320488-0.1884963643.4111.757C0
4945RARG59.024773890.9443463133.5912.694C0
4946AALA59.024773890.9443463132.3661.684C0
4947RARG59.319701140.9571612761.22.309E0
4948TTHR59.260715690.9545982831.4781.13E0
4949VVAL58.022021230.9007754411.7751.518E0
4950AALA36.78725914-0.0219018521.4681.207E0
4951GGLY57.609123080.8828344941.411.031E0
4952VVAL57.412504920.8742911861.3311.063C0
4953SSER58.769170270.9332400131.7140.891H0
4954IILE35.3322847-0.0851223341.6751.166H0
4955CCYS4.974439638-1.4042091311.8831.298H1
4956SSER55.131734170.775188811.7121.045H2
4957TTHR57.432166730.8751455161.4781.023H2
4958MMET57.39284310.8734368551.5381.394H2
4959TTHR57.412504920.8742911861.5631.009H2
4960NASN26.0519072-0.4883664841.8490.805H2
4961RARG59.359024770.9588699371.9451.292H2
4962QGLN47.719229260.4531060881.941.232H2
4963FPHE27.03499803-0.4456499431.9190.948H2
4964HHIS59.182068420.951180961.780.847C2
4965QGLN57.451828550.8759998471.8911.058H2
4966KLYS57.27487220.868310871.9921.485H2
4967LLEU4.895792371-1.4076264541.951.277H1
4968LLEU57.491152180.8777085091.8311.146H1
4969KLYS57.530475820.879417172.1211.756H2
4970SSER57.432166730.8751455162.2881.191H2
4971IILE48.092803780.4693383731.8831.108H2
4972AALA27.31026347-0.4336893111.9371.188C2
4973AALA29.55171058-0.3362955972.0851.255C2
4974TTHR54.325599690.7401612462.2751.196C2
4975RARG57.451828550.8759998472.342.202C1
4976GGLY36.80692096-0.0210475222.231.264C0
4977AALA44.612662210.3181218172.2911.238C0
4978TTHR24.38065277-0.5609846051.8431.228E1
4979VVAL45.65473850.3634013511.7261.119E2
4980VVAL57.550137630.8802715011.8151.192E2
4981IILE59.575304760.9682675771.9761.124C1
4982GGLY59.653952030.97168492.2751.103C0
4983TTHR56.449075890.8324289752.121.233C0
4984SSER6.331104994-1.3452603041.5621.072C0
4985KLYS59.594966570.9691219070.9370.987C1
4986FPHE59.182068420.951180961.3671.041C2
4987YTYR57.923712150.8965037871.5311.231C2
4988GGLY58.867479360.9375116671.2781.055H1
4989GGLY58.769170270.9332400131.0080.941H1
4990WTRP57.707432170.8871061480.8070.909H2
4991HHIS5.741250492-1.3708902290.8571.049H1
4992NASN38.02595360.031920991.0481.453H0
4993MMET57.727093980.8879604791.0411.315H0
4994LLEU57.923712150.8965037871.051.486H0
4995KLYS32.20605584-0.2209609351.3161.89H0
4996TTHR19.77978765-0.7608980181.5511.254H0
4997VVAL4.895792371-1.4076264541.3591.519H1
4998YTYR15.19858435-0.9599571011.4051.487H1
4999SSER5.367675973-1.3871225151.941.582H0
5000DASP30.84939048-0.2799097622.9432.263C1
5001VVAL55.387337790.786295113.6392.231C2
5002EGLU29.82697601-0.3243349655.3683.601C2
5003NASN43.000393240.2480666894.4232.922C2
5004PPRO53.716083370.713676992.3931.891C1
5005HHIS15.45418797-0.94885081.5071.435E0
5006LLEU57.963035780.8982124491.4061.549E1
5007MMET56.547384980.8367006291.3931.518E1
5008GGLY62.603224541.0998345241.7211.095E0
5009WTRP61.364530081.0460116821.8131.098C1
5010DASP64.176169881.168180992.0171.329C2
5011YTYR64.510420761.1827046142.0780.942T1
5012PPRO64.628391661.1878305991.5011.09T0
5013KLYS69.543845851.4014133061.8221.531T0
5014CCYS70.448289421.4407125241.6810.973T0
5015DASP70.841525761.4577991411.6341.261C0
5016RARG77.034998031.7269133511.530.846C0
5017AALA71.844278411.5013700131.5481.018C0
5018MMET51.101061740.600050991.7290.982C0
5019PPRO83.720015732.0173858331.9660.853H1
5020NASN76.445143531.7012834261.7030.883H2
5021MMET56.429414080.8315746441.5551.024H2
5022LLEU36.64962643-0.0278821681.0891.077H2
5023RARG84.703106572.0601023741.1870.749H2
5024IILE47.660243810.4505430951.7461.054H2
5025MMET8.592213921-1.2470122591.9361.098H2
5026AALA40.994887930.1609249451.8840.959H2
5027SSER50.216279980.5616061032.2020.926H2
5028LLEU47.483287460.4428541182.291.085H2
5029VVAL36.72827369-0.0244648452.0581.154H2
5030LLEU88.183248132.211318932.051.186H2
5031AALA52.949272510.6803580881.9741.089T1
5032RARG51.002752650.5957793361.8031.058T0
5033KLYS88.714117182.2343858631.9191.456T0
5034HHIS89.677546212.2762480732.0771.016T0
5035TTHR31.95045222-0.2320672362.7811.781C0
5036TTHR53.775068820.7162399823.7142.042C0
5037CCYS90.542666142.313838633.0341.316C1
5038CCYS90.739284312.3223819382.4091.112C2
5039SSER29.8073142-0.3251892962.1731.287H4
5040LLEU7.982697601-1.2734965151.9971.385H4
5041SSER53.716083370.713676992.2351.328H3
5042HHIS7.196224931-1.3076697482.1651.209H4
5043RARG87.534408182.1831260131.9131.397H6
5044FPHE64.687377111.1903935921.9271.075H5
5045YTYR83.267793941.9977362241.9721.014H5
5046RARG93.472276842.4411339231.8970.999H4
5047LLEU93.629571372.447968571.6351.258H3
5048AALA39.697208020.104539111.4550.987H3
5049NASN95.910342122.5470709461.5520.891H2
5050EGLU95.930003932.5479252761.5880.926H0
5051CCYS53.676759730.7119683281.5790.792H1
5052AALA90.287062522.3027323291.5280.957H1
5053QGLN93.629571372.447968571.6030.819H1
5054VVAL93.43295322.4394252611.7320.975C1
5055LLEU93.963822262.4624921941.4810.992C1
5056SSER53.303185210.6957360431.5051.154C2
5057EGLU93.904836812.4599292011.3420.906C1
5058MMET16.10302792-0.9206578831.3461.191E1
5059VVAL92.449862372.396708721.1861.089E2
5060MMET19.44553677-0.7754216420.9961.193E2
5061CCYS39.382618950.0908698170.860.993E1
5062GGLY39.343295320.0891611551.1531.15T0
5063GGLY92.194258752.3856024191.1761.165T0
5064SSER7.471490366-1.2957091161.0231.055E1
5065LLEU12.64254817-1.0710201080.9531.292E2
5066YTYR93.944160442.4616378630.9260.94E2
5067VVAL59.339362960.9580156071.5971.206E1
5068KLYS95.831694852.5436536221.0451.19C0
5069PPRO95.949665752.5487796071.1371.146C0
5070GGLY95.733385762.5393819681.0921.005C0
5071GGLY95.753047582.5402362991.0791.146C0
5072TTHR95.635076682.5351103141.5260.986C0
5073SSER56.075501380.8161966891.4230.813T0
5074SSER95.635076682.5351103141.2780.938T0
5075GGLY95.812033032.5427992911.3880.876T0
5076DASP95.517105782.5299843291.430.793T0
5077AALA86.964215492.1583504191.7861.027C1
5078TTHR91.093197012.3377598931.680.925H2
5079TTHR95.320487612.5214410211.4990.857H1
5080AALA95.30082582.520586691.6550.954H0
5081YTYR81.10499411.9037598331.8240.947H0
5082AALA94.357058592.479578811.7240.961H0
5083NASN95.241840352.5180236971.7130.835H1
5084SSER92.980731422.4197756521.6360.874H2
5085VVAL87.927644512.200212631.9541.077H2
5086FPHE93.118364142.4257559681.7550.826H4
5087NASN94.828942192.500082751.5290.997H3
5088IILE92.764451442.4103780131.7711.073H6
5089CCYS25.61934723-0.5071617622.0320.905H7
5090QGLN93.07904052.4240473061.8040.855H6
5091AALA88.930397172.2437835021.7351.074H6
5092VVAL62.367282741.0895825541.8871.145H8
5093TTHR21.45104208-0.6882798982.1021.055H8
5094AALA84.9783722.0720630062.0141.074H8
5095NASN92.902084152.4163583292.0251.034H7
5096VVAL70.585922141.446692842.2311.215H7
5097NASN50.648839950.5804013812.2561.117H6
5098AALA26.91702713-0.4507759282.291.232H5
5099LLEU82.147070391.9490393662.3821.548H4
5100LLEU66.555249711.271555022.4071.409H2
5101SSER68.108533231.3390471562.3851.397H2
5102TTHR15.57215887-0.9437248152.2921.49C2
5103DASP43.727880460.279676932.6471.638T2
5104GGLY35.72552104-0.0680357172.9091.578T2
5105NASN65.96539521.2459250953.2162.14T1
5106KLYS34.72276838-0.1116065892.9272.577T1
5107IILE49.331498230.5231612152.6631.637C2
5108AALA7.373181282-1.299980772.6721.86C2
5109DASP30.77074322-0.2833270862.7961.81H5
5110KLYS19.38655132-0.7779846352.8592.671H5
5111YTYR14.74636256-0.979606712.7011.811H6
5112VVAL65.25756981.2151691862.7361.539H7
5113RARG29.55171058-0.3362955972.981.956H8
5114NASN10.02752654-1.1846461093.0431.78H8
5115LLEU73.417223751.5697164792.8381.58H8
5116QGLN89.520251672.2694134272.8541.403H7
5117HHIS12.28863547-1.0863980633.0951.746H7
5118RARG30.59378687-0.2910160633.0931.582H7
5119LLEU86.688950062.1463897882.671.29H6
5120YTYR92.567833272.4018347052.9811.47H4
5121EGLU21.43138026-0.6891342293.2161.629H4
5122CCYS26.85804168-0.453338923.1431.389H1
5123LLEU7.589461266-1.2905831312.9431.447H1
5124YTYR93.039716872.4223386453.4031.215H2
5125RARG92.469524182.3975630513.8761.538C2
5126NASN10.9123083-1.1462012214.4811.589C2
5127RARG7.215886748-1.3068154174.542.843C1
5128DASP8.159653952-1.2658075374.2161.829C1
5129VVAL59.142744790.9494722984.7491.577C2
5130DASP88.084939052.2070472762.9361.521H2
5131TTHR2.752654345-1.5007485152.6741.823H2
5132DASP7.491152182-1.2948547852.3771.65H1
5133FPHE79.099488791.8166180882.181.289H2
5134VVAL83.503735752.0079881932.0671.282H4
5135NASN9.712937475-1.1983154022.0011.579H4
5136EGLU42.84309870.2412320421.9871.484H7
5137FPHE33.18914668-0.1782443941.8981.169H6
5138YTYR77.192292571.7337479981.8341.213H6
5139AALA19.4848604-0.7737129811.9751.336H5
5140YTYR59.909555640.9827912011.9411.195H6
5141LLEU80.16122691.8627519531.9421.255H6
5142RARG38.812426270.0660942231.8552.017H2
5143KLYS83.130161231.9917559081.8691.927H4
5144HHIS70.625245771.4484015021.7861.217H3
5145FPHE84.27054662.0413070961.7371.206H1
5146SSER78.234368861.7790275321.5251.122E2
5147MMET71.293747541.477448751.7151.281E1
5148MMET28.03775069-0.4020790711.4391.341E1
5149IILE27.15296893-0.4405239581.4781.176E2
5150LLEU28.25403067-0.3926814321.9321.213E2
5151SSER27.27093983-0.4353979731.8830.927T1
5152DASP65.434526151.2228581631.6161.088T1
5153DASP26.77939442-0.4567562441.7481.245E1
5154AALA4.679512387-1.4170240941.6221.109E1
5155VVAL57.117577660.8614762231.5631.42E2
5156VVAL23.4762092-0.6002838231.541.221E3
5157CCYS23.65316555-0.5925948451.4551.244E1
5158FPHE1.238694455-1.5665319881.3771.649E1
5159NASN35.29296107-0.0868309952.0361.329T3
5160SSER24.81321274-0.5421893262.3251.618T2
5161TTHR14.33346441-0.9975476572.4731.74T2
5162YTYR25.30475816-0.5208310562.0251.413T4
5163AALA40.817931580.1532359672.4161.409T2
5164SSER10.47974833-1.1649964992.5121.718T2
5165QGLN17.67597326-0.8523114172.5351.728T3
5166GGLY39.107353520.0789091852.5111.312T1
5167LLEU17.75462053-0.8488940932.271.392C1
5168VVAL38.753440820.063531231.9481.524C2
5169AALA57.215886750.8657478771.8371.211C2
5170SSER5.623279591-1.3760162142.3791.407H1
5171IILE43.747542270.280531261.7551.608H2
5172KLYS4.797483287-1.4118981092.0071.647H2
5173NASN15.15926072-0.9616657632.0661.06H4
5174FPHE59.968541090.9853541931.8210.995H4
5175KLYS34.60479748-0.1167325741.6551.159H4
5176SSER1.494298073-1.5554256881.7461.013H4
5177VVAL30.06291781-0.3140829951.6981.111H4
5178LLEU59.948879280.9844998621.5431.162H3
5179YTYR55.583955960.7948384191.4740.964H2
5180YTYR57.451828550.8759998471.6360.955H1
5181QGLN57.943373970.8973581181.6431.127H1
5182NASN57.943373970.8973581181.4650.828C3
5183NASN56.095163190.817051020.9770.86C1
5184VVAL55.701926860.7999644041.0331.361C0
5185FPHE45.576091230.3599840271.2971.152C0
5186MMET55.564294140.7939840882.0241.41C0
5187SSER44.691309480.321539141.5851.246T0
5188EGLU23.45654738-0.6011381532.0451.194T0
5189AALA19.1309477-0.7890909352.4191.478T0
5190KLYS57.15690130.8631848852.5282.023T0
5191CCYS55.387337790.786295111.8471.05C0
5192WTRP57.019268580.8572045691.3681.441E1
5193TTHR8.375933936-1.2564098981.4421.572E2
5194EGLU55.348014160.7845864491.4941.265E1
5195TTHR16.49626425-0.9035712662.0541.804C0
5196DASP54.797483290.7606651852.6841.56T0
5197LLEU29.61069603-0.3337326042.5192.492T1
5198TTHR8.710184821-1.2418862742.31.957T2
5199KLYS39.716869840.1053934411.9182.145T1
5200GGLY55.190719620.7777518021.3321.174C0
5201PPRO55.112072360.7743344791.1821.035C0
5202HHIS55.957530480.8110707041.6621.44C0
5203EGLU55.878883210.8076533811.7581.549C0
5204FPHE55.465985060.7897124341.2021.034E0
5205CCYS55.230043260.7794604641.371.182T0
5206SSER55.465985060.7897124341.071.165T0
5207QGLN53.539127020.7059880131.181.164E0
5208HHIS54.10931970.7307636071.2581.117E0
5209TTHR22.70939835-0.6336027251.0281.035E1
5210MMET13.90090444-1.0163429361.2971.346E2
5211LLEU13.88124263-1.0171972661.071.309E1
5212VVAL32.52064491-0.2072916421.0161.334E0
5213KLYS22.02123476-0.6635043041.1762.002E0
5214QGLN4.581203303-1.4212957481.4491.921E0
5215GGLY24.02674007-0.5763625591.8671.755T0
5216DASP13.23240267-1.0453901841.852.075T0
5217DASP24.59693276-0.5515869651.3521.638E0
5218YTYR7.923712151-1.2760595071.1081.574E0
5219VVAL13.80259536-1.020614590.9711.55E1
5220YTYR43.354305940.2634446440.9251.076E2
5221LLEU52.359418010.6547281630.8991.159E1
5222PPRO52.457727090.6589998171.1350.872E0
5223YTYR52.634683440.6666887941.4320.991E0
5224PPRO52.81163980.6743777721.5261.153C0
5225DASP47.660243810.4505430951.7241.276H0
5226PPRO50.412898150.5701494111.531.241H1
5227SSER52.713330710.6701061182.0211.221H2
5228RARG52.732992530.6709604491.9191.538H2
5229IILE53.814392450.7179486441.7661.721H2
5230LLEU51.690916240.6256809152.1641.828H4
5231GGLY24.38065277-0.5609846052.4731.256H3
5232AALA52.634683440.6666887942.2891.335H4
5233GGLY41.958316950.2027871552.7421.398H2
5234CCYS22.61108926-0.6378743792.8921.517H10
5235FPHE52.575697990.6641258023.3641.442H5
5236VVAL52.988596150.6820667493.3771.633C3
5237DASP52.909948880.6786494263.6261.518C2
5238DASP46.677152970.4078265544.8781.902C2
5239IILE18.46244593-0.8181381844.5422.261G1
5240VVAL31.04600865-0.2713664543.9381.968G0
5241KLYS52.556036180.6632714714.4893.247G1
5242TTHR49.88202910.5470824794.5342.779G2
5243DASP44.199764060.300180874.6122.572H2
5244GGLY14.07786079-1.0086539584.4262.339H2
5245TTHR13.95988989-1.0137799434.2032.365H2
5246LLEU22.61108926-0.6378743794.2312.325H2
5247MMET16.29964609-0.9121145754.132.084H2
5248IILE13.07510814-1.052224833.4722.006H3
5249EGLU53.04758160.6846297423.4211.87H1
5250RARG52.398741640.6564368253.4112.257H2
5251FPHE21.41171844-0.6899885593.2491.691H2
5252VVAL42.528509630.2275627492.931.602H3
5253SSER44.101454970.2959092152.7631.394H2
5254LLEU52.418403460.6572911552.6961.347H2
5255AALA52.261108930.6504565092.4721.272H3
5256IILE52.241447110.6496021782.141.278H2
5257DASP52.398741640.6564368252.1971.062H2
5258AALA52.241447110.6496021782.1511.171H2
5259YTYR52.182461660.6470391851.7481.177H2
5260PPRO52.182461660.6470391851.3771.013C3
5261LLEU52.241447110.6496021781.7441.206T2
5262TTHR18.50176956-0.8164295221.8251.306T3
5263KLYS35.37160834-0.0834136721.7221.692T2
5264HHIS49.823043650.5445194861.7161.309T2
5265PPRO10.83366103-1.1496185451.971.674C2
5266NASN36.86590641-0.0184845292.3351.571H2
5267QGLN4.502556036-1.4247130712.472.517H2
5268EGLU47.365316560.4377281332.7111.859H1
5269YTYR49.64608730.5368305092.3551.368H1
5270AALA4.423908769-1.4281303942.5851.474H2
5271DASP4.404246952-1.4289847252.9311.568H5
5272VVAL52.300432560.652165172.4421.43H4
5273FPHE51.985843490.6384958772.3081.268H6
5274HHIS4.404246952-1.4289847252.9741.559H8
5275LLEU6.861974046-1.3221933723.0951.609H8
5276YTYR22.21785293-0.6549609962.8131.373H7
5277LLEU52.025167130.6402045393.0941.621H9
5278QGLN13.97955171-1.0129256123.4922.195H8
5279YTYR32.93354306-0.1893506953.6461.7H9
5280IILE33.13016123-0.1808073863.4821.608H9
5281RARG14.76602438-0.9787523793.7292.009H8
5282KLYS30.55446323-0.2927247254.122.587H9
5283LLEU52.064490760.64191324.0082.274H8
5284HHIS6.213134094-1.3503862894.152.318H9
5285DASP4.423908769-1.4281303944.9222.571H8
5286EGLU15.55249705-0.9445791465.1312.965H8
5287LLEU51.671254420.6248265845.0312.989H7
5288TTHR13.86158081-1.0180515975.1273.132H6
5289GGLY13.84191899-1.0189059285.9513.6H5
5290HHIS13.78293354-1.021468926.6294.524H5
5291MMET21.45104208-0.6882798986.685.262H3
5292LLEU51.848210770.6325155617.2845.074H3
5293DASP28.29335431-0.390972776.9995.14C5
5294MMET4.443570586-1.4272760636.6076.073C4
5295YTYR30.49547778-0.2952877177.0256.201C3
5296SSER49.508454580.5308501935.9713.956C4
5297VVAL40.621313410.1446926594.6323.204C1
5298MMET13.94022808-1.0146342744.2142.563C1
5299LLEU38.478175380.0515705993.8041.918C1
5300TTHR4.423908769-1.4281303942.8942.034C0
5301NASN4.502556036-1.4247130712.3142.018H0
5302DASP37.298466380.0003107491.8261.812H0
5303NASN13.48800629-1.0342838832.8841.994H1
5304TTHR16.53558789-0.9018626052.3881.555H2
5305SSER16.35863154-0.9095515822.081.283H2
5306RARG4.60086512-1.4204414172.141.877H2
5307YTYR5.092410539-1.3990831462.0761.303C2
5308WTRP41.152182460.1677595911.6510.992C2
5309EGLU23.3582383-0.6054098081.8481.354C2
5310PPRO4.423908769-1.4281303942.0571.403H1
5311EGLU15.17892253-0.9608114322.9292.298H1
5312FPHE51.848210770.6325155612.9151.957H1
5313YTYR51.808887140.63080692.5311.931H0
5314EGLU13.03578451-1.0539334922.7582.29H0
5315AALA4.482894219-1.4255674023.1612.656H0
5316MMET39.579237120.0994131254.1763.848H0
5317YTYR51.808887140.63080694.6875.101H3
5318TTHR4.974439638-1.4042091316.9125.616C4
5319PPRO4.404246952-1.4289847258.0126.434C5
5320HHIS4.404246952-1.4289847258.7857.315C6
5321TTHR27.38891074-0.4302719889.5198.633C5
5322VVAL29.45340149-0.3405672519.9048.715C4
5323LLEU43.708218640.27882259912.19411.091C4
5324QGLN51.789225320.62995256911.77811.33C1

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

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