nsp9 Google Drive Data

Non-structural protein 9 (nsp9)– nsp9 may participate in viral replication by acting as a ssRNA-binding protein.² Nsp9 and nsp10 interact with NKRF, an NF-КB repressor, and may cause a IL-8/IL-6 mediated chemotaxis of neutrophils and overexuberant host inflammatory response.¹⁵ Nsp9 has also been shown to interact with nsp8 as well.⁴

nsp9 3,386 Sequences

Amino Acid	AA	AA	Conservation	Conservation Z-score	RMSD_CA	RMSF[A]	Secondary Structure	DCCM >0.9
4141	N	ASN	99.94093325	1.543147134	3.295	3.973	C	0
4142	N	ASN	99.88186651	1.54143175	3.468	3.041	C	0
4143	E	GLU	99.88186651	1.54143175	3.388	2.69	E	0
4144	L	LEU	42.35085647	-0.129352084	3.694	3.503	E	0
4145	S	SER	8.535144714	-1.111409317	2.355	2.082	E	0
4146	P	PRO	95.95392794	1.427358726	4.215	2.466	C	0
4147	V	VAL	8.623744832	-1.108836241	2.897	2.234	C	0
4148	A	ALA	8.682811577	-1.107120857	2.449	1.351	C	0
4149	L	LEU	75.07383343	0.820970548	1.657	1.205	C	0
4150	R	ARG	10.18901359	-1.06337857	1.664	1.958	E	0
4151	Q	GLN	32.66391022	-0.410675029	1.599	1.463	E	0
4152	M	MET	32.42764324	-0.417536564	1.53	1.224	E	0
4153	S	SER	25.33963379	-0.623382622	1.687	1.059	E	0
4154	C	CYS	24.06969876	-0.660263374	1.094	0.851	E	0
4155	A	ALA	8.741878323	-1.105405473	1.145	0.965	E	0
4156	A	ALA	83.37271116	1.061981974	1.318	0.894	E	0
4157	G	GLY	61.54754873	0.428147655	1.103	0.77	E	0
4158	T	THR	8.682811577	-1.107120857	0.983	1.36	C	0
4159	T	THR	14.79621973	-0.929578632	1.335	1.257	T	1
4160	Q	GLN	34.14057885	-0.367790434	1.878	1.244	T	2
4161	T	THR	18.87182516	-0.811217149	2.418	1.655	T	2
4162	A	ALA	8.860011813	-1.101974706	2.184	1.395	T	1
4163	C	CYS	8.505611341	-1.112267008	2.09	1.288	C	0
4164	T	THR	8.653278204	-1.107978549	1.708	1.432	T	0
4165	D	ASP	8.535144714	-1.111409317	2.778	1.655	T	0
4166	D	ASP	8.505611341	-1.112267008	1.586	1.322	T	0
4167	N	ASN	9.48021264	-1.083963176	1.644	1.097	T	0
4168	A	ALA	11.42941524	-1.02735551	1.478	0.889	E	0
4169	L	LEU	31.57117543	-0.44240963	1.362	1.477	E	0
4170	A	ALA	66.89308919	0.58338989	1.189	0.83	E	0
4171	Y	TYR	61.78381571	0.435009191	1.266	1.178	E	0
4172	Y	TYR	92.61665682	1.330439541	1.404	0.897	E	0
4173	N	ASN	48.55286474	0.050763217	1.103	1.367	E	0
4174	T	THR	11.81334908	-1.016205515	2.232	2.462	E	0
4175	T	THR	3.573538098	-1.255501557	3.849	2.599	E	1
4176	K	LYS	9.214412286	-1.091682403	4.533	3.906	T	1
4177	G	GLY	85.67631424	1.128881943	3.492	2.852	T	0
4178	G	GLY	22.79976373	-0.697144126	2.852	2.189	E	0
4179	R	ARG	11.9019492	-1.013632439	1.381	2.113	E	0
4180	F	PHE	42.91199055	-0.113055938	1.141	1.133	E	0
4181	V	VAL	39.95865328	-0.198825128	1.081	0.898	E	0
4182	L	LEU	8.535144714	-1.111409317	1.088	1.14	E	0
4183	A	ALA	98.31659776	1.495974079	1.152	0.746	E	0
4184	L	LEU	33.04784406	-0.399525034	1.277	0.894	E	0
4185	L	LEU	46.89899587	0.00273247	1.424	1.073	E	0
4186	S	SER	86.35558181	1.148608857	1.358	0.687	E	0
4187	D	ASP	66.09568813	0.560232209	1.279	0.998	C	0
4188	L	LEU	1.949202599	-1.302674612	1.237	1.273	C	0
4189	Q	GLN	8.476077968	-1.1131247	1.111	1.569	C	0
4190	D	ASP	34.43591258	-0.359213515	1.008	1.5	C	0
4191	L	LEU	96.54459539	1.444512564	0.761	0.916	C	0
4192	K	LYS	81.6007088	1.01052046	0.765	1.771	E	0
4193	W	TRP	31.48257531	-0.444982705	1.019	0.957	E	0
4194	A	ALA	47.96219728	0.033609378	1.505	0.901	E	0
4195	R	ARG	30.68517425	-0.468140387	1.597	1.706	E	0
4196	F	PHE	24.06969876	-0.660263374	0.935	1.438	E	0
4197	P	PRO	8.505611341	-1.112267008	3.319	1.49	E	0
4198	K	LYS	9.066745422	-1.095970862	5.517	2.424	E	0
4199	S	SER	9.303012404	-1.089109327	8.73	2.656	T	0
4200	D	ASP	20.82102776	-0.754609484	8.663	3.17	T	1
4201	G	GLY	9.184878913	-1.092540095	7.853	2.826	T	1
4202	T	THR	8.446544595	-1.113982392	5.617	2.921	C	0
4203	G	GLY	59.53927939	0.369824606	3.914	1.972	E	1
4204	T	THR	8.505611341	-1.112267008	1.55	1.771	E	1
4205	I	ILE	31.36444182	-0.448413473	2.768	2.274	E	0
4206	Y	TYR	23.68576491	-0.671413369	1.606	1.257	E	0
4207	T	THR	7.501476669	-1.141428533	0.949	0.908	E	0
4208	E	GLU	80.77377437	0.986505086	0.768	1.203	E	0
4209	L	LEU	99.94093325	1.543147134	0.793	0.831	C	0
4210	E	GLU	40.72652097	-0.176525139	0.819	0.997	C	0
4211	P	PRO	89.3975192	1.236951123	1.098	1.007	C	0
4212	P	PRO	99.64559953	1.534570215	1.344	0.978	C	0
4213	C	CYS	70.31896043	0.682882152	1.247	1.108	E	0
4214	R	ARG	25.93030124	-0.606228784	1.169	1.842	E	0
4215	F	PHE	99.97046663	1.544004826	1.609	0.948	E	0
4216	V	VAL	11.69521559	-1.019636283	1.798	1.326	E	0
4217	T	THR	8.535144714	-1.111409317	2.088	1.327	E	0
4218	D	ASP	35.94211459	-0.315471227	2.317	1.479	C	0
4219	T	THR	16.68635558	-0.87468635	3.13	1.664	T	1
4220	P	PRO	58.56467809	0.341520773	3.786	2.449	T	2
4221	K	LYS	46.01299468	-0.022998287	3.359	2.935	T	1
4222	G	GLY	70.76196102	0.69574753	2.65	1.663	T	0
4223	P	PRO	47.46012995	0.019028616	2.122	1.483	C	0
4224	K	LYS	22.85883048	-0.695428742	1.961	1.909	E	0
4225	V	VAL	40.16538689	-0.192821285	1.665	1.19	E	0
4226	K	LYS	56.61547549	0.284913107	1.291	1.12	E	0
4227	Y	TYR	99.23213231	1.522562528	1.008	0.788	E	0
4228	L	LEU	99.85233314	1.540574058	1.185	0.981	E	0
4229	Y	TYR	99.88186651	1.54143175	1.069	0.588	E	0
4230	F	PHE	98.64146486	1.50540869	0.721	0.767	E	0
4231	I	ILE	29.09037212	-0.51445575	0.639	1.034	E	0
4232	K	LYS	76.87536917	0.873289755	0.805	1.592	T	0
4233	G	GLY	22.85883048	-0.695428742	0.943	0.95	T	0
4234	L	LEU	66.74542233	0.579101431	0.805	1.033	T	0
4235	N	ASN	79.79917307	0.958201253	0.923	1.435	H	0
4236	N	ASN	37.18251624	-0.279448167	0.826	1.066	H	0
4237	L	LEU	84.31777909	1.089428115	0.932	1.2	H	0
4238	N	ASN	12.40401654	-0.999051677	0.79	1	H	0
4239	R	ARG	99.79326639	1.538858674	0.721	0.898	H	0
4240	G	GLY	99.88186651	1.54143175	0.891	0.749	H	0
4241	M	MET	28.05670408	-0.544474966	0.84	1.419	H	0
4242	V	VAL	96.98759598	1.457377943	0.863	0.995	H	0
4243	L	LEU	82.27997637	1.030247374	1.077	0.953	H	0
4244	G	GLY	99.73419965	1.53714329	1.266	0.873	H	0
4245	S	SER	8.38747785	-1.115697776	1.415	1.056	H	0
4246	L	LEU	12.58121677	-0.993905525	1.319	1.466	H	0
4247	A	ALA	32.48670998	-0.415821181	1.695	1.179	H	0
4248	A	ALA	66.09568813	0.560232209	2.238	1.381	H	0
4249	T	THR	83.99291199	1.079993504	2.291	1.35	H	0
4250	V	VAL	91.2285883	1.290128021	2.175	1.59	H	0
4251	R	ARG	79.94683993	0.962489713	2.701	2.235	C	0
4252	L	LEU	99.85233314	1.540574058	2.053	1.385	C	0
4253	Q	GLN	99.37979917	1.526850987	2.951	2.013	C	0

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

4.            Rani R, Singh A, Pareek A, Tomar S. In silico Guided Drug Repurposing to Combat SARS-CoV-2 by Targeting Mpro, the key virus specific protease. 2020;

15.         Li J, Guo M, Tian X, et al. Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis. bioRxiv 2020;2020.03.31.019216.