nsp8 Google Drive Data
Non-structural protein 8 (nsp8)– nsp8 interacts with nsp7 to form a hexadecamer that may act as a primase.2 Nsp12-nsp7-nsp8 complex of SARS-CoV-2 is essential for viral replication and transcription and is a potential target to fight against the virus. Seven compounds (Saquinavir, Tipranavir, Lonafarnib, Tegobuvir, Olysio, Filibuvir, and Cepharanthine) were found to interact well with nsp12-nsp7-nsp8 indicating potential as drug candidates.14

Dynamics Data for Interaction

nsp8 3,339 Sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
3943 | A | ALA | 46.87032046 | -0.084730397 | 6.887 | 5.449 | H | 2 |
3944 | I | ILE | 8.565438754 | -1.316139018 | 4.496 | 4.787 | H | 2 |
3945 | A | ALA | 42.64749925 | -0.22048381 | 5.936 | 4.718 | C | 1 |
3946 | S | SER | 77.44833783 | 0.898278361 | 5.008 | 5.148 | C | 1 |
3947 | E | GLU | 62.41389638 | 0.414957698 | 5.624 | 7.207 | C | 2 |
3948 | F | PHE | 71.75801138 | 0.71534823 | 6.304 | 7.398 | C | 4 |
3949 | S | SER | 48.21802935 | -0.04140484 | 6.46 | 5.885 | C | 3 |
3950 | S | SER | 12.42887092 | -1.191939087 | 5.401 | 4.578 | H | 3 |
3951 | L | LEU | 60.88649296 | 0.3658554 | 6.258 | 6.011 | H | 6 |
3952 | P | PRO | 57.74183887 | 0.264762433 | 7.077 | 5.386 | H | 3 |
3953 | S | SER | 77.08894879 | 0.886724879 | 5.654 | 3.628 | H | 2 |
3954 | Y | TYR | 51.84186882 | 0.07509277 | 4.928 | 4.148 | H | 2 |
3955 | A | ALA | 47.46930219 | -0.065474594 | 6.298 | 4.503 | H | 4 |
3956 | A | ALA | 24.79784367 | -0.794306748 | 6.638 | 3.998 | H | 3 |
3957 | F | PHE | 2.425876011 | -1.513511002 | 5.458 | 3.317 | H | 3 |
3958 | A | ALA | 8.625336927 | -1.314213437 | 5.926 | 4.028 | H | 3 |
3959 | T | THR | 14.07607068 | -1.138985627 | 7.142 | 4.583 | H | 4 |
3960 | A | ALA | 99.61066187 | 1.610743083 | 7.229 | 4.108 | H | 4 |
3961 | Q | GLN | 32.34501348 | -0.551683627 | 6.922 | 4.662 | H | 9 |
3962 | E | GLU | 8.924827793 | -1.304585536 | 7.782 | 5.518 | H | 8 |
3963 | A | ALA | 35.93890386 | -0.436148807 | 8.641 | 5.269 | H | 7 |
3964 | Y | TYR | 80.65289009 | 1.001296909 | 8.651 | 5.863 | H | 15 |
3965 | E | GLU | 57.38244984 | 0.253208951 | 8.932 | 6.318 | H | 9 |
3966 | Q | GLN | 8.77508236 | -1.309399487 | 9.711 | 6.745 | H | 11 |
3967 | A | ALA | 79.48487571 | 0.963748092 | 10.146 | 6.669 | H | 13 |
3968 | V | VAL | 34.14195867 | -0.493916217 | 10.29 | 7.421 | H | 10 |
3969 | A | ALA | 19.76639712 | -0.956055496 | 10.662 | 7.811 | H | 10 |
3970 | N | ASN | 41.15004492 | -0.268623319 | 11.215 | 7.847 | H | 11 |
3971 | G | GLY | 82.68942797 | 1.06676664 | 11.698 | 8.39 | H | 11 |
3972 | D | ASP | 32.10542078 | -0.559385948 | 11.529 | 7.741 | C | 15 |
3973 | S | SER | 48.15813118 | -0.04333042 | 12.38 | 8.487 | H | 12 |
3974 | E | GLU | 8.6852351 | -1.312287857 | 11.65 | 8.865 | H | 11 |
3975 | V | VAL | 8.6852351 | -1.312287857 | 11.604 | 8.403 | H | 11 |
3976 | V | VAL | 33.6328242 | -0.51028365 | 10.665 | 7.307 | H | 12 |
3977 | L | LEU | 63.37226715 | 0.445766984 | 9.616 | 7.129 | H | 15 |
3978 | K | LYS | 83.61784966 | 1.096613135 | 9.351 | 7.799 | H | 13 |
3979 | K | LYS | 12.51871818 | -1.189050716 | 9.32 | 6.771 | H | 11 |
3980 | L | LEU | 79.78436658 | 0.973375994 | 8.375 | 5.657 | H | 14 |
3981 | K | LYS | 18.62833184 | -0.992641522 | 7.448 | 6.187 | H | 12 |
3982 | K | LYS | 77.02905061 | 0.884799299 | 7.465 | 6.423 | H | 12 |
3983 | S | SER | 8.595387841 | -1.315176228 | 7.447 | 4.828 | H | 9 |
3984 | L | LEU | 8.565438754 | -1.316139018 | 6.179 | 4.243 | H | 9 |
3985 | N | ASN | 99.64061096 | 1.611705873 | 5.634 | 4.764 | H | 6 |
3986 | V | VAL | 31.68613357 | -0.572865011 | 6.06 | 4.601 | H | 5 |
3987 | A | ALA | 99.88020365 | 1.619408194 | 5.475 | 3.315 | H | 2 |
3988 | K | LYS | 99.64061096 | 1.611705873 | 4.411 | 4.011 | H | 2 |
3989 | S | SER | 65.79814316 | 0.523752987 | 4.657 | 3.594 | H | 2 |
3990 | E | GLU | 43.78556454 | -0.183897784 | 5 | 3.624 | H | 0 |
3991 | F | PHE | 56.90326445 | 0.237804308 | 3.863 | 2.952 | H | 0 |
3992 | D | ASP | 53.0098832 | 0.112641587 | 3.602 | 3.105 | H | 0 |
3993 | R | ARG | 69.33213537 | 0.637362226 | 4.703 | 4.446 | H | 0 |
3994 | D | ASP | 62.68343816 | 0.42362281 | 5.013 | 3.612 | H | 1 |
3995 | A | ALA | 37.88559449 | -0.373567446 | 3.979 | 3.355 | H | 3 |
3996 | A | ALA | 66.63671758 | 0.550711112 | 5.102 | 3.815 | H | 4 |
3997 | M | MET | 8.565438754 | -1.316139018 | 6.29 | 4.875 | H | 7 |
3998 | Q | GLN | 61.57532195 | 0.387999574 | 5.588 | 4.966 | H | 10 |
3999 | R | ARG | 65.10931417 | 0.501608813 | 6.039 | 5.039 | H | 12 |
4000 | K | LYS | 99.76040731 | 1.615557034 | 7.742 | 5.615 | H | 12 |
4001 | L | LEU | 91.07517221 | 1.336347886 | 7.79 | 5.64 | H | 14 |
4002 | E | GLU | 51.09314166 | 0.051023016 | 6.953 | 5.556 | H | 16 |
4003 | K | LYS | 17.66996107 | -1.023450808 | 8.943 | 6.164 | H | 17 |
4004 | M | MET | 95.5375861 | 1.479803621 | 10.082 | 6.541 | H | 18 |
4005 | A | ALA | 99.25127284 | 1.599189601 | 9.029 | 6.35 | H | 20 |
4006 | D | ASP | 49.86522911 | 0.011548619 | 9.973 | 6.4 | H | 21 |
4007 | Q | GLN | 63.28241989 | 0.442878613 | 12.264 | 6.815 | H | 21 |
4008 | A | ALA | 99.85025457 | 1.618445404 | 12.006 | 7.196 | H | 22 |
4009 | M | MET | 52.65049416 | 0.101088105 | 11.169 | 7.509 | H | 22 |
4010 | T | THR | 65.28900869 | 0.507385554 | 13.483 | 7.362 | H | 22 |
4011 | Q | GLN | 33.12368973 | -0.526651083 | 14.86 | 8.077 | H | 24 |
4012 | M | MET | 99.97005091 | 1.622296565 | 13.224 | 8.173 | H | 24 |
4013 | Y | TYR | 99.22132375 | 1.598226811 | 13.791 | 8.67 | H | 26 |
4014 | K | LYS | 95.9868224 | 1.494245473 | 15.975 | 8.867 | T | 26 |
4015 | Q | GLN | 32.82419886 | -0.536278984 | 16.563 | 9.085 | T | 25 |
4016 | A | ALA | 95.65738245 | 1.483654781 | 16.662 | 8.992 | T | 23 |
4017 | R | ARG | 99.73045822 | 1.614594244 | 17.903 | 9.257 | T | 23 |
4018 | S | SER | 11.62024558 | -1.217934421 | 19.035 | 9.475 | C | 23 |
4019 | E | GLU | 36.98712189 | -0.402451151 | 20.191 | 9.906 | C | 22 |
4020 | D | ASP | 73.61485475 | 0.77504122 | 21.019 | 9.96 | C | 21 |
4021 | K | LYS | 47.46930219 | -0.065474594 | 19.578 | 10.657 | C | 20 |
4022 | R | ARG | 28.75112309 | -0.667218447 | 18.396 | 10.707 | H | 18 |
4023 | A | ALA | 47.73884397 | -0.056809482 | 15.996 | 8.513 | H | 17 |
4024 | K | LYS | 99.49086553 | 1.606891922 | 13.96 | 8.253 | H | 20 |
4025 | V | VAL | 51.06319257 | 0.050060226 | 13.712 | 8.445 | H | 21 |
4026 | T | THR | 13.44713986 | -1.159204221 | 13.624 | 7.523 | H | 17 |
4027 | S | SER | 98.80203654 | 1.584747749 | 11.03 | 6.13 | H | 18 |
4028 | A | ALA | 79.12548667 | 0.95219461 | 9.796 | 6.255 | H | 18 |
4029 | M | MET | 65.7082959 | 0.520864617 | 10.962 | 7.204 | H | 7 |
4030 | Q | GLN | 46.7804732 | -0.087618768 | 9.593 | 5.603 | H | 8 |
4031 | T | THR | 46.96016771 | -0.081842027 | 7.267 | 4.608 | H | 5 |
4032 | M | MET | 51.63222522 | 0.068353239 | 8.399 | 6.06 | H | 5 |
4033 | L | LEU | 100 | 1.623259355 | 9.638 | 6.039 | H | 4 |
4034 | F | PHE | 95.44773884 | 1.47691525 | 6.977 | 4.346 | H | 4 |
4035 | T | THR | 8.595387841 | -1.315176228 | 7.21 | 4.722 | H | 3 |
4036 | M | MET | 99.97005091 | 1.622296565 | 10.153 | 6.366 | H | 6 |
4037 | L | LEU | 61.54537287 | 0.387036784 | 10.13 | 5.435 | H | 5 |
4038 | R | ARG | 54.98652291 | 0.176185738 | 9.079 | 5.233 | H | 6 |
4039 | K | LYS | 69.33213537 | 0.637362226 | 11.546 | 6.966 | H | 7 |
4040 | L | LEU | 84.27672956 | 1.117794519 | 14.001 | 7.439 | H | 9 |
4041 | D | ASP | 99.85025457 | 1.618445404 | 13.132 | 6.84 | C | 8 |
4042 | N | ASN | 46.18149146 | -0.106874571 | 12.487 | 6.253 | C | 8 |
4043 | D | ASP | 37.25666367 | -0.39378604 | 12.266 | 6.62 | H | 8 |
4044 | A | ALA | 23.36028751 | -0.840520676 | 11.208 | 5.554 | H | 9 |
4045 | L | LEU | 62.44384546 | 0.415920489 | 10.357 | 4.729 | H | 10 |
4046 | N | ASN | 68.40371369 | 0.607515731 | 10.562 | 5.409 | H | 10 |
4047 | N | ASN | 10.6918239 | -1.247780916 | 9.839 | 5.216 | H | 9 |
4048 | I | ILE | 74.03414196 | 0.788520282 | 8.482 | 3.692 | H | 8 |
4049 | I | ILE | 37.52620545 | -0.385120928 | 8.861 | 4.065 | H | 5 |
4050 | N | ASN | 33.87241689 | -0.502581329 | 9.229 | 5.211 | H | 7 |
4051 | N | ASN | 46.81042228 | -0.086655977 | 7.57 | 4.063 | H | 5 |
4052 | A | ALA | 100 | 1.623259355 | 6.732 | 3.397 | H | 4 |
4053 | R | ARG | 45.61245882 | -0.125167584 | 8.392 | 5.388 | H | 5 |
4054 | D | ASP | 32.70440252 | -0.540130145 | 8.094 | 5.006 | H | 5 |
4055 | G | GLY | 95.95687332 | 1.493282683 | 6.376 | 4.019 | C | 3 |
4056 | C | CYS | 47.82869122 | -0.053921112 | 5.133 | 3.394 | C | 2 |
4057 | V | VAL | 66.69661575 | 0.552636692 | 5.093 | 2.964 | E | 0 |
4058 | P | PRO | 99.97005091 | 1.622296565 | 5.79 | 2.642 | E | 0 |
4059 | L | LEU | 94.75890985 | 1.454771076 | 6.443 | 3.399 | E | 2 |
4060 | N | ASN | 21.26385145 | -0.907915988 | 9.126 | 4.033 | E | 5 |
4061 | I | ILE | 19.70649895 | -0.957981076 | 10.707 | 3.724 | E | 7 |
4062 | I | ILE | 78.28691225 | 0.925236486 | 13.962 | 4.941 | C | 8 |
4063 | P | PRO | 96.01677149 | 1.495208263 | 16.736 | 5.595 | C | 7 |
4064 | L | LEU | 32.49475891 | -0.546869676 | 19.503 | 7.03 | C | 6 |
4065 | T | THR | 15.99281222 | -1.077367057 | 19.124 | 7.366 | C | 5 |
4066 | T | THR | 10.87151842 | -1.242004175 | 16.871 | 7.657 | C | 5 |
4067 | A | ALA | 54.08805031 | 0.147302033 | 13.027 | 6.473 | C | 2 |
4068 | A | ALA | 10.06289308 | -1.26799951 | 12.858 | 5.112 | E | 10 |
4069 | K | LYS | 73.88439653 | 0.783706332 | 10.817 | 4.843 | E | 6 |
4070 | L | LEU | 99.64061096 | 1.611705873 | 8.032 | 3.049 | E | 6 |
4071 | M | MET | 8.715184187 | -1.311325067 | 6.245 | 3.609 | E | 4 |
4072 | V | VAL | 47.73884397 | -0.056809482 | 3.881 | 2.752 | E | 0 |
4073 | V | VAL | 79.42497754 | 0.961822512 | 3.55 | 3.407 | E | 4 |
4074 | I | ILE | 35.8490566 | -0.439037178 | 5.178 | 3.781 | E | 8 |
4075 | P | PRO | 76.01078167 | 0.852064433 | 7.055 | 4.657 | C | 6 |
4076 | D | ASP | 93.74064091 | 1.422036211 | 10.414 | 5.967 | H | 14 |
4077 | Y | TYR | 9.104522312 | -1.298808795 | 11.473 | 6.939 | H | 13 |
4078 | N | ASN | 2.156334232 | -1.522176113 | 12.33 | 6.86 | H | 7 |
4079 | T | THR | 24.13896376 | -0.815488132 | 9.581 | 5.084 | H | 8 |
4080 | Y | TYR | 45.79215334 | -0.119390843 | 7.981 | 5.044 | H | 12 |
4081 | K | LYS | 9.254267745 | -1.293994844 | 10.148 | 6.813 | H | 9 |
4082 | N | ASN | 8.116202456 | -1.33058087 | 10.394 | 5.873 | H | 7 |
4083 | T | THR | 9.224318658 | -1.294957634 | 7.426 | 3.983 | E | 5 |
4084 | C | CYS | 9.314165918 | -1.292069264 | 6.217 | 4.319 | E | 7 |
4085 | D | ASP | 22.91105121 | -0.854962529 | 7.948 | 4.752 | E | 5 |
4086 | G | GLY | 28.12219227 | -0.68743704 | 6.817 | 4.525 | T | 3 |
4087 | T | THR | 2.096436059 | -1.524101693 | 4.094 | 4.058 | T | 2 |
4088 | T | THR | 12.87810722 | -1.177497234 | 4.029 | 3.804 | E | 2 |
4089 | F | PHE | 8.924827793 | -1.304585536 | 4.214 | 2.919 | E | 2 |
4090 | T | THR | 37.8556454 | -0.374530237 | 7.563 | 4.015 | E | 2 |
4091 | Y | TYR | 96.16651692 | 1.500022214 | 8.859 | 3.248 | E | 4 |
4092 | A | ALA | 79.99401018 | 0.980115525 | 12.937 | 4.548 | T | 7 |
4093 | S | SER | 8.595387841 | -1.315176228 | 14.566 | 5.392 | T | 4 |
4094 | A | ALA | 38.87391435 | -0.341795371 | 12.118 | 4.458 | E | 4 |
4095 | L | LEU | 32.10542078 | -0.559385948 | 8.576 | 4.211 | E | 2 |
4096 | W | TRP | 95.74722971 | 1.486543152 | 6.795 | 3.344 | E | 3 |
4097 | E | GLU | 8.595387841 | -1.315176228 | 5.434 | 3.673 | E | 1 |
4098 | I | ILE | 89.81731057 | 1.295910699 | 4.691 | 3.495 | E | 3 |
4099 | Q | GLN | 25.48667266 | -0.772162575 | 7.538 | 4.751 | E | 4 |
4100 | Q | GLN | 9.224318658 | -1.294957634 | 8.145 | 5.222 | E | 7 |
4101 | V | VAL | 39.95208146 | -0.307134925 | 7.602 | 4.667 | E | 13 |
4102 | V | VAL | 9.284216831 | -1.293032054 | 8.998 | 5.441 | E | 13 |
4103 | D | ASP | 72.17729859 | 0.728827292 | 10.208 | 6.245 | E | 16 |
4104 | A | ALA | 35.10032944 | -0.463106932 | 10.097 | 6.277 | T | 14 |
4105 | D | ASP | 94.33962264 | 1.441292014 | 12.96 | 7.69 | T | 11 |
4106 | S | SER | 8.984725966 | -1.302659955 | 12.158 | 6.795 | E | 9 |
4107 | K | LYS | 32.70440252 | -0.540130145 | 13.978 | 7.9 | E | 11 |
4108 | I | ILE | 31.74603175 | -0.57093943 | 12.609 | 7.064 | E | 12 |
4109 | V | VAL | 64.95956873 | 0.496794862 | 11.734 | 6.326 | C | 16 |
4110 | Q | GLN | 29.43995208 | -0.645074273 | 11.436 | 6.859 | T | 9 |
4111 | L | LEU | 33.15363881 | -0.525688293 | 9.326 | 5.291 | T | 6 |
4112 | S | SER | 32.0754717 | -0.560348738 | 12.004 | 6.948 | T | 8 |
4113 | E | GLU | 51.12309075 | 0.051985806 | 13.954 | 7.564 | T | 15 |
4114 | I | ILE | 31.14705001 | -0.590195234 | 12.069 | 6.108 | C | 15 |
4115 | S | SER | 14.85474693 | -1.113953083 | 14.345 | 7.894 | T | 12 |
4116 | M | MET | 8.595387841 | -1.315176228 | 16.311 | 9.07 | T | 10 |
4117 | D | ASP | 32.46480982 | -0.547832466 | 18.937 | 9.783 | T | 12 |
4118 | N | ASN | 43.00688829 | -0.208930328 | 17.404 | 8.814 | T | 16 |
4119 | S | SER | 9.493860437 | -1.286292523 | 15.719 | 8.315 | C | 14 |
4120 | P | PRO | 8.445642408 | -1.319990178 | 17.058 | 9.475 | C | 14 |
4121 | N | ASN | 53.63881402 | 0.13286018 | 17.396 | 9.472 | C | 13 |
4122 | L | LEU | 62.53369272 | 0.418808859 | 14.333 | 7.546 | C | 15 |
4123 | A | ALA | 25.63641809 | -0.767348624 | 12.893 | 7.246 | C | 14 |
4124 | W | TRP | 95.5375861 | 1.479803621 | 10.132 | 6.736 | C | 15 |
4125 | P | PRO | 99.61066187 | 1.610743083 | 7.646 | 5.121 | C | 13 |
4126 | L | LEU | 94.90865529 | 1.459585027 | 6.994 | 5.031 | E | 17 |
4127 | I | ILE | 14.67505241 | -1.119729824 | 5.398 | 4.038 | E | 12 |
4128 | V | VAL | 30.57801737 | -0.608488247 | 4.666 | 3.256 | E | 6 |
4129 | T | THR | 19.8262953 | -0.954129916 | 6.323 | 3.838 | E | 5 |
4130 | A | ALA | 23.51003294 | -0.835706726 | 6.265 | 3.148 | E | 6 |
4131 | L | LEU | 8.565438754 | -1.316139018 | 8.514 | 4.478 | E | 5 |
4132 | R | ARG | 99.52081462 | 1.607854713 | 9.938 | 5.262 | E | 4 |
4133 | A | ALA | 10.21263851 | -1.263185559 | 10.591 | 4.258 | C | 3 |
4134 | N | ASN | 8.595387841 | -1.315176228 | 14.157 | 6.194 | C | 1 |
4135 | S | SER | 43.24648098 | -0.201228007 | 13.763 | 6.004 | C | 1 |
4136 | A | ALA | 41.26984127 | -0.264772158 | 16.987 | 7.27 | C | 2 |
4137 | V | VAL | 60.3474094 | 0.348525177 | 14.827 | 7.047 | C | 2 |
4138 | K | LYS | 65.40880503 | 0.511236715 | 13.841 | 8.623 | C | 2 |
4139 | L | LEU | 76.19047619 | 0.857841174 | 13.47 | 9.829 | C | 2 |
4140 | Q | GLN | 76.22042528 | 0.858803964 | 13.217 | 7.608 | C | 2 |
2. I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/
14. Ruan Z, Liu C, Guo Y, et al. Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2. 2020 [cited 2020 Apr 8];Available from: https://www.preprints.org/manuscript/202003.0024/v1