nsp7 Google Drive Data
Non-structural protein 7 (nsp7)– nsp7 interacts with nsp8 to form a hexadecamer that may act as a primase.2 Nsp12-nsp7-nsp8 complex of SARS-CoV-2 is essential for viral replication and transcription and is a potential target to fight against the virus. Seven compounds (Saquinavir, Tipranavir, Lonafarnib, Tegobuvir, Olysio, Filibuvir, and Cepharanthine) were found to interact well with nsp12-nsp7-nsp8 indicating potential as drug candidates.14

Dynamics Data for Interaction

nsp7 3,256 Sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
3860 | S | SER | 96.13022113 | 1.439375744 | 3.704 | 4.007 | H | 0 |
3861 | K | LYS | 99.10933661 | 1.532222699 | 3.058 | 3.655 | H | 3 |
3862 | M | MET | 9.459459459 | -1.261800609 | 2.464 | 2.507 | H | 5 |
3863 | S | SER | 24.35503686 | -0.797565836 | 2.83 | 3.09 | H | 7 |
3864 | D | ASP | 94.74815725 | 1.396302414 | 2.883 | 3.176 | H | 8 |
3865 | V | VAL | 37.16216216 | -0.398419649 | 2.233 | 2.316 | H | 8 |
3866 | K | LYS | 99.81572482 | 1.554237956 | 2.169 | 2.31 | H | 7 |
3867 | C | CYS | 96.28378378 | 1.444161669 | 2.663 | 3.079 | H | 9 |
3868 | T | THR | 67.22972973 | 0.538664565 | 2.405 | 2.687 | H | 8 |
3869 | S | SER | 33.78378378 | -0.50371001 | 1.636 | 1.899 | H | 9 |
3870 | V | VAL | 99.87714988 | 1.556152326 | 2.006 | 2.679 | H | 5 |
3871 | V | VAL | 99.81572482 | 1.554237956 | 2.322 | 2.948 | H | 10 |
3872 | L | LEU | 96.43734644 | 1.448947595 | 1.808 | 2.143 | H | 6 |
3873 | L | LEU | 76.41277641 | 0.82486291 | 1.516 | 1.995 | H | 6 |
3874 | S | SER | 33.47665848 | -0.513281861 | 2.223 | 2.634 | H | 7 |
3875 | V | VAL | 33.72235872 | -0.50562438 | 2.19 | 2.628 | H | 6 |
3876 | L | LEU | 99.93857494 | 1.558066696 | 1.489 | 1.54 | H | 8 |
3877 | Q | GLN | 46.22235872 | -0.116050044 | 1.978 | 2.472 | H | 5 |
3878 | Q | GLN | 33.72235872 | -0.50562438 | 2.491 | 3.257 | H | 8 |
3879 | L | LEU | 62.71498771 | 0.397958355 | 1.968 | 2.326 | H | 3 |
3880 | R | ARG | 9.520884521 | -1.259886239 | 1.779 | 3.203 | T | 2 |
3881 | V | VAL | 65.14127764 | 0.473575978 | 1.161 | 1.419 | T | 0 |
3882 | E | GLU | 55.8968059 | 0.185463262 | 2.06 | 2.23 | T | 1 |
3883 | S | SER | 31.23464373 | -0.583156373 | 2.471 | 1.751 | T | 1 |
3884 | S | SER | 9.551597052 | -1.258929054 | 1.923 | 1.852 | H | 2 |
3885 | S | SER | 95.36240786 | 1.415446116 | 2.352 | 2.509 | H | 4 |
3886 | K | LYS | 50.98280098 | 0.032313646 | 2.386 | 3.257 | H | 4 |
3887 | L | LEU | 22.26658477 | -0.862654422 | 1.532 | 1.534 | H | 3 |
3888 | W | TRP | 80.12899263 | 0.940682307 | 1.407 | 2.157 | H | 2 |
3889 | A | ALA | 73.74078624 | 0.741587806 | 1.958 | 2.097 | H | 5 |
3890 | Q | GLN | 8.814496314 | -1.281901496 | 1.53 | 2.14 | H | 3 |
3891 | C | CYS | 80.0982801 | 0.939725122 | 0.856 | 0.93 | H | 0 |
3892 | V | VAL | 87.5 | 1.170406731 | 1.548 | 1.966 | H | 1 |
3893 | Q | GLN | 9.398034398 | -1.26371498 | 1.774 | 2.331 | H | 2 |
3894 | L | LEU | 72.78869779 | 0.711915068 | 1.118 | 1.519 | H | 1 |
3895 | H | HIS | 100 | 1.559981067 | 1.373 | 1.666 | H | 2 |
3896 | N | ASN | 100 | 1.559981067 | 1.92 | 2.132 | H | 3 |
3897 | D | ASP | 36.73218673 | -0.41182024 | 1.583 | 1.564 | H | 0 |
3898 | I | ILE | 96.19164619 | 1.441290114 | 1.318 | 1.403 | H | 1 |
3899 | L | LEU | 66.06265356 | 0.502291531 | 2.019 | 2.52 | H | 3 |
3900 | L | LEU | 42.87469287 | -0.22038322 | 2.119 | 2.382 | H | 3 |
3901 | A | ALA | 36.64004914 | -0.414691795 | 1.662 | 1.777 | C | 2 |
3902 | K | LYS | 8.968058968 | -1.277115571 | 1.89 | 2.985 | C | 1 |
3903 | D | ASP | 94.502457 | 1.388644934 | 1.665 | 2.14 | H | 0 |
3904 | T | THR | 9.152334152 | -1.27137246 | 1.792 | 2.304 | H | 1 |
3905 | T | THR | 10.68796069 | -1.223513205 | 2.015 | 2.499 | H | 3 |
3906 | E | GLU | 54.11547912 | 0.129946527 | 1.747 | 2.074 | H | 2 |
3907 | A | ALA | 74.23218673 | 0.756902767 | 1.344 | 1.636 | H | 1 |
3908 | F | PHE | 46.22235872 | -0.116050044 | 1.69 | 2.362 | H | 3 |
3909 | E | GLU | 74.84643735 | 0.776046469 | 1.598 | 2.145 | H | 3 |
3910 | K | LYS | 52.48771499 | 0.079215716 | 1.155 | 1.731 | H | 2 |
3911 | M | MET | 8.906633907 | -1.279029941 | 1.361 | 1.904 | H | 3 |
3912 | V | VAL | 37.07002457 | -0.401291204 | 1.864 | 2.234 | H | 5 |
3913 | S | SER | 32.06388206 | -0.557312375 | 1.453 | 1.606 | H | 1 |
3914 | L | LEU | 83.75307125 | 1.053630149 | 1.03 | 1.288 | H | 2 |
3915 | L | LEU | 68.7039312 | 0.584609449 | 1.72 | 2.283 | H | 3 |
3916 | S | SER | 13.11425061 | -1.147895582 | 1.978 | 2.035 | H | 3 |
3917 | V | VAL | 21.92874693 | -0.873183459 | 1.556 | 1.544 | H | 1 |
3918 | L | LEU | 62.56142506 | 0.393172429 | 1.637 | 2.24 | H | 3 |
3919 | L | LEU | 43.18181818 | -0.210811369 | 2.089 | 2.814 | H | 5 |
3920 | S | SER | 44.96314496 | -0.155294633 | 2.008 | 2.125 | H | 2 |
3921 | M | MET | 8.968058968 | -1.277115571 | 2.204 | 1.832 | H | 2 |
3922 | Q | GLN | 11.21007371 | -1.207241059 | 2.549 | 2.885 | H | 3 |
3923 | G | GLY | 32.89312039 | -0.531468378 | 2.342 | 2.244 | C | 0 |
3924 | A | ALA | 40.97051597 | -0.279728696 | 2.773 | 2.915 | H | 0 |
3925 | V | VAL | 49.38574939 | -0.017459979 | 2.988 | 3.598 | H | 0 |
3926 | D | ASP | 71.22235872 | 0.663098628 | 2.247 | 2.408 | H | 0 |
3927 | I | ILE | 21.92874693 | -0.873183459 | 1.933 | 2.203 | H | 0 |
3928 | N | ASN | 12.19287469 | -1.176611135 | 2.535 | 2.913 | H | 0 |
3929 | K | LYS | 4.699017199 | -1.4101643 | 2.602 | 3.342 | H | 0 |
3930 | L | LEU | 67.90540541 | 0.559722637 | 2.569 | 3.17 | H | 0 |
3931 | C | CYS | 36.82432432 | -0.408948685 | 3.239 | 2.921 | H | 0 |
3932 | E | GLU | 30.0982801 | -0.618572222 | 3.817 | 3.176 | H | 0 |
3933 | E | GLU | 9.459459459 | -1.261800609 | 4.019 | 4.028 | H | 1 |
3934 | M | MET | 8.814496314 | -1.281901496 | 4.447 | 4.478 | H | 3 |
3935 | L | LEU | 29.94471744 | -0.623358147 | 7.291 | 5.38 | T | 2 |
3936 | D | ASP | 36.60933661 | -0.415648981 | 9.137 | 6.706 | T | 2 |
3937 | N | ASN | 28.40909091 | -0.671217402 | 6.913 | 6.624 | T | 5 |
3938 | R | ARG | 10.16584767 | -1.239785352 | 5.775 | 6.041 | T | 3 |
3939 | A | ALA | 12.96068796 | -1.152681508 | 6.697 | 7.252 | C | 3 |
3940 | T | THR | 11.85503686 | -1.187140171 | 8.121 | 8.213 | C | 4 |
3941 | L | LEU | 96.4987715 | 1.450861965 | 9.933 | 7.431 | C | 2 |
3942 | Q | GLN | 99.69287469 | 1.550409216 | 11.133 | 9.663 | C | 1 |
2. I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/
14. Ruan Z, Liu C, Guo Y, et al. Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2. 2020 [cited 2020 Apr 8];Available from: https://www.preprints.org/manuscript/202003.0024/v1