nsp10 Google Drive Data
Non-structural protein 10 (nsp10)– nsp10 stimulates nsp14 3′-5′ exoribonuclease and nsp16 2′-O-methyltransferase activities. Due to its activities with nsp14 and 16 it is involved with viral mRNAs cap methylation.2 Nsp9 and nsp10 interact with NKRF, an NF-КB repressor, and may cause a IL-8/IL-6 mediated chemotaxis of neutrophils and overexuberant host inflammatory response.15 Certain -N=N and -COOH based Protein-nucleic acid interface inhibitors show good binding energy with nsp10/16 protein.16



nsp10 3,344 Sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
4254 | A | ALA | 79.84449761 | 0.632911923 | 14.872 | 10.54 | C | 1 |
4255 | G | GLY | 99.76076555 | 1.196521764 | 11.349 | 8.486 | C | 2 |
4256 | N | ASN | 8.761961722 | -1.378650531 | 8.261 | 7.622 | C | 2 |
4257 | A | ALA | 23.02631579 | -0.974984022 | 6.618 | 7.137 | C | 2 |
4258 | T | THR | 95.6638756 | 1.080584004 | 4.82 | 5.897 | C | 2 |
4259 | E | GLU | 99.61124402 | 1.192290459 | 3.922 | 4.179 | H | 1 |
4260 | V | VAL | 9.300239234 | -1.363417832 | 3.102 | 3.657 | H | 0 |
4261 | P | PRO | 14.4138756 | -1.218707197 | 2.484 | 3.197 | H | 0 |
4262 | A | ALA | 11.48325359 | -1.301640778 | 2.502 | 2.72 | H | 0 |
4263 | N | ASN | 83.91148325 | 0.748003422 | 2.209 | 2.468 | H | 0 |
4264 | S | SER | 79.60526316 | 0.626141834 | 1.973 | 1.869 | H | 0 |
4265 | T | THR | 9.18062201 | -1.366802876 | 1.865 | 1.681 | H | 0 |
4266 | V | VAL | 32.47607656 | -0.707565539 | 2.546 | 1.747 | H | 0 |
4267 | L | LEU | 99.64114833 | 1.19313672 | 2.43 | 1.783 | H | 0 |
4268 | S | SER | 62.52990431 | 0.14292679 | 2.545 | 1.843 | H | 0 |
4269 | F | PHE | 8.821770335 | -1.376958009 | 2.674 | 2.236 | H | 1 |
4270 | C | CYS | 72.30861244 | 0.419654145 | 1.798 | 1.417 | H | 1 |
4271 | A | ALA | 58.28349282 | 0.022757725 | 2.395 | 1.735 | H | 0 |
4272 | F | PHE | 99.94019139 | 1.201599331 | 2.24 | 2.061 | H | 0 |
4273 | A | ALA | 58.10406699 | 0.017680158 | 1.795 | 1.398 | C | 0 |
4274 | V | VAL | 93.92942584 | 1.031500865 | 2.09 | 1.919 | C | 0 |
4275 | D | ASP | 99.16267943 | 1.179596544 | 1.861 | 1.302 | H | 1 |
4276 | A | ALA | 2.21291866 | -1.563981695 | 1.181 | 1.12 | H | 1 |
4277 | A | ALA | 56.45933014 | -0.028864198 | 1.315 | 1.138 | H | 0 |
4278 | K | LYS | 73.20574163 | 0.445041975 | 1.045 | 1.967 | H | 0 |
4279 | A | ALA | 46.86004785 | -0.300513987 | 1.138 | 1.181 | H | 0 |
4280 | Y | TYR | 99.88038278 | 1.199906808 | 1.102 | 1.078 | H | 0 |
4281 | K | LYS | 9.419856459 | -1.360032788 | 1.822 | 1.906 | H | 1 |
4282 | D | ASP | 74.94019139 | 0.494125115 | 2.182 | 1.318 | H | 2 |
4283 | Y | TYR | 29.48564593 | -0.792191641 | 2.26 | 1.366 | H | 1 |
4284 | L | LEU | 13.03827751 | -1.257635204 | 2.648 | 1.713 | H | 1 |
4285 | A | ALA | 27.78110048 | -0.84042852 | 3.201 | 1.686 | H | 1 |
4286 | S | SER | 28.02033493 | -0.833658431 | 3.658 | 1.804 | C | 1 |
4287 | G | GLY | 99.97009569 | 1.202445592 | 4.042 | 1.66 | C | 1 |
4288 | G | GLY | 51.25598086 | -0.176113616 | 2.867 | 1.416 | C | 0 |
4289 | Q | GLN | 29.72488038 | -0.785421553 | 2.589 | 1.934 | C | 0 |
4290 | P | PRO | 99.94019139 | 1.201599331 | 2.056 | 1.513 | C | 0 |
4291 | I | ILE | 25.98684211 | -0.891204181 | 1.38 | 1.211 | C | 0 |
4292 | T | THR | 36.93181818 | -0.581472646 | 1.377 | 1.875 | C | 0 |
4293 | N | ASN | 95.93301435 | 1.088200353 | 1.991 | 2.305 | C | 0 |
4294 | C | CYS | 99.34210526 | 1.18467411 | 0.922 | 0.999 | C | 0 |
4295 | V | VAL | 91.38755981 | 0.959568678 | 1.13 | 1.233 | C | 0 |
4296 | K | LYS | 95.99282297 | 1.089892875 | 1.225 | 1.891 | C | 0 |
4297 | M | MET | 99.88038278 | 1.199906808 | 1.164 | 1.294 | C | 0 |
4298 | L | LEU | 95.78349282 | 1.083969048 | 1.657 | 1.899 | C | 0 |
4299 | C | CYS | 22.75717703 | -0.982600372 | 1.446 | 1.262 | C | 0 |
4300 | T | THR | 12.47009569 | -1.273714164 | 1.885 | 1.418 | C | 0 |
4301 | H | HIS | 39.08492823 | -0.520541853 | 2.126 | 1.252 | C | 0 |
4302 | T | THR | 33.28349282 | -0.684716491 | 2.192 | 1.348 | C | 0 |
4303 | G | GLY | 100 | 1.203291853 | 1.503 | 0.982 | C | 0 |
4304 | T | THR | 48.23564593 | -0.261585979 | 1.332 | 1.172 | C | 0 |
4305 | G | GLY | 99.97009569 | 1.202445592 | 0.874 | 0.781 | C | 0 |
4306 | Q | GLN | 36.18421053 | -0.602629172 | 0.763 | 1.046 | C | 0 |
4307 | A | ALA | 99.97009569 | 1.202445592 | 0.664 | 0.863 | E | 0 |
4308 | I | ILE | 73.89354067 | 0.464505979 | 0.676 | 1.018 | E | 0 |
4309 | T | THR | 75.98684211 | 0.523744251 | 0.886 | 0.894 | E | 1 |
4310 | V | VAL | 43.86961722 | -0.385140089 | 1.078 | 1.44 | C | 1 |
4311 | T | THR | 12.29066986 | -1.27879173 | 1.112 | 1.154 | C | 0 |
4312 | P | PRO | 66.8062201 | 0.263942116 | 1.094 | 1.047 | C | 0 |
4313 | E | GLU | 62.73923445 | 0.148850617 | 1.21 | 1.08 | C | 0 |
4314 | A | ALA | 51.01674641 | -0.182883704 | 1.356 | 0.97 | C | 0 |
4315 | N | ASN | 28.64832536 | -0.81588695 | 1.461 | 1.269 | T | 0 |
4316 | M | MET | 10.16746411 | -1.338876263 | 1.86 | 1.856 | T | 0 |
4317 | D | ASP | 48.29545455 | -0.259893457 | 1.819 | 1.401 | T | 1 |
4318 | Q | GLN | 99.97009569 | 1.202445592 | 1.476 | 0.864 | T | 2 |
4319 | E | GLU | 32.6854067 | -0.701641712 | 1.153 | 1.302 | E | 2 |
4320 | S | SER | 72.99641148 | 0.439118148 | 0.893 | 0.886 | E | 1 |
4321 | F | PHE | 9.748803828 | -1.350723917 | 0.845 | 0.867 | E | 0 |
4322 | G | GLY | 100 | 1.203291853 | 0.944 | 0.852 | T | 0 |
4323 | G | GLY | 100 | 1.203291853 | 0.905 | 0.809 | T | 0 |
4324 | A | ALA | 99.70095694 | 1.194829242 | 1.064 | 1.047 | T | 0 |
4325 | S | SER | 99.97009569 | 1.202445592 | 1.369 | 0.882 | T | 0 |
4326 | C | CYS | 9.629186603 | -1.354108961 | 1.273 | 0.724 | C | 0 |
4327 | C | CYS | 99.94019139 | 1.201599331 | 1.271 | 0.656 | H | 0 |
4328 | L | LEU | 75.71770335 | 0.516127901 | 1.259 | 1.073 | H | 0 |
4329 | Y | TYR | 99.13277512 | 1.178750283 | 0.897 | 0.867 | H | 0 |
4330 | C | CYS | 99.94019139 | 1.201599331 | 1.239 | 0.894 | H | 0 |
4331 | R | ARG | 99.97009569 | 1.202445592 | 1.684 | 1.217 | H | 1 |
4332 | C | CYS | 14.50358852 | -1.216168414 | 1.486 | 1.087 | H | 1 |
4333 | H | HIS | 85.22727273 | 0.785238907 | 1.555 | 1.736 | C | 0 |
4334 | I | ILE | 53.19976077 | -0.12110665 | 1.318 | 1.25 | C | 0 |
4335 | D | ASP | 10.49641148 | -1.329567391 | 1.273 | 1.38 | C | 0 |
4336 | H | HIS | 100 | 1.203291853 | 0.999 | 1.038 | C | 0 |
4337 | P | PRO | 99.79066986 | 1.197368025 | 1.53 | 1.34 | C | 0 |
4338 | N | ASN | 24.28229665 | -0.939441059 | 2.543 | 1.627 | T | 1 |
4339 | P | PRO | 8.911483254 | -1.374419226 | 2.822 | 2.131 | T | 1 |
4340 | K | LYS | 8.791866029 | -1.37780427 | 2.252 | 2.855 | T | 1 |
4341 | G | GLY | 99.91028708 | 1.20075307 | 1.854 | 1.546 | T | 2 |
4342 | F | PHE | 30.71172249 | -0.757494939 | 2.717 | 2.344 | C | 2 |
4343 | C | CYS | 99.94019139 | 1.201599331 | 1.962 | 1.307 | C | 1 |
4344 | D | ASP | 8.791866029 | -1.37780427 | 2.07 | 1.576 | C | 0 |
4345 | L | LEU | 42.34449761 | -0.428299401 | 1.299 | 1.075 | T | 0 |
4346 | K | LYS | 84.92822967 | 0.776776297 | 1.498 | 2.055 | T | 0 |
4347 | G | GLY | 99.49162679 | 1.188905415 | 1.272 | 1.089 | T | 0 |
4348 | K | LYS | 77.75119617 | 0.573673651 | 0.766 | 1.268 | T | 0 |
4349 | Y | TYR | 30.2930622 | -0.769342594 | 0.74 | 1.302 | E | 0 |
4350 | V | VAL | 99.82057416 | 1.198214286 | 0.764 | 0.947 | E | 0 |
4351 | Q | GLN | 96.23205742 | 1.096662964 | 0.925 | 0.893 | E | 0 |
4352 | I | ILE | 55.32296651 | -0.061022117 | 1.312 | 0.939 | E | 1 |
4353 | P | PRO | 96.02272727 | 1.090739136 | 1.341 | 0.915 | T | 2 |
4354 | T | THR | 29.60526316 | -0.788806597 | 1.674 | 1.447 | T | 1 |
4355 | T | THR | 24.07296651 | -0.945364887 | 1.813 | 1.471 | T | 0 |
4356 | C | CYS | 34.47966507 | -0.65086605 | 1.686 | 1.086 | T | 1 |
4357 | A | ALA | 8.911483254 | -1.374419226 | 1.639 | 1.167 | C | 2 |
4358 | N | ASN | 9.210526316 | -1.365956615 | 2.226 | 1.465 | C | 2 |
4359 | D | ASP | 62.88875598 | 0.153081922 | 1.926 | 1.067 | H | 2 |
4360 | P | PRO | 100 | 1.203291853 | 1.412 | 1.011 | H | 2 |
4361 | V | VAL | 65.34090909 | 0.222475326 | 1.635 | 1.132 | H | 1 |
4362 | G | GLY | 49.19258373 | -0.234505627 | 1.946 | 1.083 | H | 1 |
4363 | F | PHE | 85.43660287 | 0.791162734 | 1.511 | 0.907 | H | 1 |
4364 | T | THR | 8.70215311 | -1.380343053 | 1.494 | 1.065 | H | 0 |
4365 | L | LEU | 92.19497608 | 0.982417725 | 1.714 | 1.82 | H | 0 |
4366 | K | LYS | 2.781100478 | -1.547902735 | 1.396 | 1.877 | H | 0 |
4367 | N | ASN | 82.08732057 | 0.696381499 | 1.328 | 0.937 | C | 0 |
4368 | T | THR | 35.73564593 | -0.615323087 | 1.325 | 1.381 | C | 0 |
4369 | V | VAL | 70.06578947 | 0.356184568 | 0.955 | 1.162 | C | 0 |
4370 | C | CYS | 100 | 1.203291853 | 0.799 | 0.864 | C | 0 |
4371 | T | THR | 24.61124402 | -0.930132188 | 1.304 | 1.334 | C | 0 |
4372 | V | VAL | 95.30502392 | 1.070428872 | 1.192 | 1.378 | C | 0 |
4373 | C | CYS | 100 | 1.203291853 | 0.995 | 0.933 | C | 0 |
4374 | G | GLY | 53.52870813 | -0.111797778 | 0.932 | 0.847 | C | 0 |
4375 | M | MET | 9.539473684 | -1.356647744 | 0.724 | 1.051 | C | 0 |
4376 | W | TRP | 99.94019139 | 1.201599331 | 0.902 | 0.804 | T | 0 |
4377 | K | LYS | 9.210526316 | -1.365956615 | 1.075 | 1.58 | T | 0 |
4378 | G | GLY | 52.18301435 | -0.149879524 | 1.335 | 1.035 | T | 0 |
4379 | Y | TYR | 44.82655502 | -0.358059736 | 1.255 | 1.153 | T | 0 |
4380 | G | GLY | 82.11722488 | 0.69722776 | 1.038 | 0.988 | C | 0 |
4381 | C | CYS | 99.91028708 | 1.20075307 | 0.879 | 0.886 | C | 0 |
4382 | S | SER | 24.40191388 | -0.936056015 | 1.155 | 1.263 | C | 0 |
4383 | C | CYS | 99.82057416 | 1.198214286 | 1.186 | 1.072 | C | 0 |
4384 | D | ASP | 80.74162679 | 0.658299753 | 1.971 | 1.736 | T | 0 |
4385 | Q | GLN | 8.70215311 | -1.380343053 | 2.707 | 2.715 | T | 0 |
4386 | L | LEU | 48.50478469 | -0.25396963 | 3.047 | 3.034 | T | 0 |
4387 | R | ARG | 48.74401914 | -0.247199542 | 2.242 | 3.217 | T | 0 |
4388 | E | GLU | 9.868421053 | -1.347338873 | 1.851 | 2.006 | C | 0 |
4389 | P | PRO | 22.63755981 | -0.985985416 | 3.018 | 2.738 | C | 0 |
4390 | M | MET | 4.90430622 | -1.487818203 | 4.429 | 4.934 | C | 1 |
4391 | L | LEU | 25.17942584 | -0.914053229 | 5.673 | 5.931 | C | 1 |
4392 | Q | GLN | 9.210526316 | -1.365956615 | 6.99 | 5.907 | C | 0 |
2. I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/
15. Li J, Guo M, Tian X, et al. Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis. bioRxiv 2020;2020.03.31.019216.
16. Khadim Sheikh H, Arshad T, Mohammad ZS, Arshad I, Hassan M. PROTEIN-NUCLEIC ACID INTERFACE (PNAI) INHIBITOR DRUG MOLECULES FOR SARS-COV-2. 2020 [cited 2020 Apr 9];Available from: https://chemrxiv.org/articles/PROTEIN-NUCLEIC_ACID_INTERFACE_PNAI_INHIBITOR_DRUG_MOLECULES_FOR_SARS-COV-2/12026736