nsp1 Google Drive Data
Assists in evasion from the immune system by suppressing host gene expression. Nsp1 interacts with the 40S ribosomal unit forming the nsp1-40s ribosome complex which causes endonucleolytic cleavage of the 5’UTR of host mRNAs, resulting in degradation. Viral mRNAs have a leader sequence on the 5’ end protecting them from this cleavage.2 In SARS-CoV, nsp1 modulates the Calcineurin/NFAT pathway which is important for immune cell activation.3

nsp1 250 sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
1 | M | MET | 100 | 0.455425776 | 12.403 | 9.753 | C | 1 |
2 | E | GLU | 100 | 0.455425776 | 10.296 | 9.68 | C | 2 |
3 | S | SER | 100 | 0.455425776 | 8.218 | 8.128 | C | 2 |
4 | L | LEU | 100 | 0.455425776 | 8.929 | 8.448 | C | 2 |
5 | V | VAL | 99.2 | 0.429322722 | 7.121 | 6.893 | C | 2 |
6 | P | PRO | 14.4 | -2.337600953 | 5.792 | 5.926 | C | 1 |
7 | G | GLY | 100 | 0.455425776 | 5.592 | 4.435 | T | 0 |
8 | F | PHE | 14.4 | -2.337600953 | 6.295 | 5.595 | T | 0 |
9 | N | ASN | 98.4 | 0.403219669 | 6.405 | 4.493 | T | 0 |
10 | E | GLU | 100 | 0.455425776 | 4.439 | 4.246 | T | 0 |
11 | K | LYS | 100 | 0.455425776 | 4.032 | 3.886 | C | 0 |
12 | T | THR | 100 | 0.455425776 | 4.617 | 2.515 | C | 1 |
13 | H | HIS | 100 | 0.455425776 | 5.735 | 2.196 | C | 3 |
14 | V | VAL | 99.6 | 0.442374249 | 5.431 | 2.702 | E | 2 |
15 | Q | GLN | 99.6 | 0.442374249 | 5.218 | 3.015 | E | 2 |
16 | L | LEU | 100 | 0.455425776 | 4.278 | 2.559 | E | 1 |
17 | S | SER | 100 | 0.455425776 | 4.109 | 3.006 | E | 2 |
18 | L | LEU | 100 | 0.455425776 | 3.134 | 2.038 | E | 2 |
19 | P | PRO | 100 | 0.455425776 | 3.022 | 2.427 | E | 5 |
20 | V | VAL | 100 | 0.455425776 | 2.835 | 2.515 | E | 7 |
21 | L | LEU | 100 | 0.455425776 | 2.948 | 2.216 | E | 5 |
22 | Q | GLN | 100 | 0.455425776 | 3.335 | 2.764 | T | 1 |
23 | V | VAL | 100 | 0.455425776 | 2.82 | 2.218 | T | 0 |
24 | R | ARG | 93.6 | 0.246601347 | 3.682 | 3.146 | T | 1 |
25 | D | ASP | 100 | 0.455425776 | 3.517 | 2.509 | T | 2 |
26 | V | VAL | 100 | 0.455425776 | 2.761 | 1.733 | C | 1 |
27 | L | LEU | 100 | 0.455425776 | 3.026 | 2.937 | C | 0 |
28 | V | VAL | 100 | 0.455425776 | 2.595 | 2.161 | C | 0 |
29 | R | ARG | 100 | 0.455425776 | 2.212 | 1.858 | C | 0 |
30 | G | GLY | 100 | 0.455425776 | 3.093 | 1.746 | C | 2 |
31 | F | PHE | 100 | 0.455425776 | 3.4 | 2.063 | C | 8 |
32 | G | GLY | 100 | 0.455425776 | 4.402 | 2.812 | C | 10 |
33 | D | ASP | 100 | 0.455425776 | 4.939 | 3.466 | C | 8 |
34 | S | SER | 93.6 | 0.246601347 | 5.571 | 4.101 | H | 10 |
35 | V | VAL | 100 | 0.455425776 | 4.943 | 3.712 | H | 10 |
36 | E | GLU | 100 | 0.455425776 | 5.475 | 4.503 | H | 7 |
37 | E | GLU | 100 | 0.455425776 | 6.093 | 4.342 | H | 10 |
38 | V | VAL | 12.4 | -2.402858586 | 4.769 | 2.995 | H | 10 |
39 | L | LEU | 99.2 | 0.429322722 | 4.531 | 2.781 | H | 10 |
40 | S | SER | 91.6 | 0.181343714 | 4.909 | 3.576 | H | 8 |
41 | E | GLU | 100 | 0.455425776 | 3.857 | 3.269 | H | 9 |
42 | A | ALA | 99.6 | 0.442374249 | 2.94 | 2.275 | H | 5 |
43 | R | ARG | 100 | 0.455425776 | 3.553 | 2.89 | H | 5 |
44 | Q | GLN | 14.4 | -2.337600953 | 3.645 | 3.822 | H | 6 |
45 | H | HIS | 100 | 0.455425776 | 2.823 | 2.747 | H | 6 |
46 | L | LEU | 100 | 0.455425776 | 2.84 | 2.622 | H | 7 |
47 | K | LYS | 99.2 | 0.429322722 | 3.839 | 3.796 | H | 6 |
48 | D | ASP | 14 | -2.350652479 | 3.393 | 3.649 | H | 6 |
49 | G | GLY | 100 | 0.455425776 | 3.171 | 3.18 | H | 6 |
50 | T | THR | 100 | 0.455425776 | 2.666 | 2.978 | E | 9 |
51 | C | CYS | 100 | 0.455425776 | 2.12 | 2.136 | E | 7 |
52 | G | GLY | 100 | 0.455425776 | 1.816 | 1.495 | E | 0 |
53 | L | LEU | 96 | 0.324910508 | 1.633 | 1.807 | E | 0 |
54 | V | VAL | 99.6 | 0.442374249 | 1.904 | 1.854 | E | 0 |
55 | E | GLU | 99.2 | 0.429322722 | 3.279 | 2.872 | C | 0 |
56 | V | VAL | 13.6 | -2.363704006 | 4.064 | 2.727 | C | 1 |
57 | E | GLU | 99.2 | 0.429322722 | 4.449 | 3.613 | C | 2 |
58 | K | LYS | 100 | 0.455425776 | 5.243 | 4.453 | C | 2 |
59 | G | GLY | 100 | 0.455425776 | 5.855 | 3.443 | C | 3 |
60 | V | VAL | 99.6 | 0.442374249 | 4.533 | 2.936 | G | 2 |
61 | L | LEU | 100 | 0.455425776 | 2.921 | 2.754 | G | 3 |
62 | P | PRO | 94.4 | 0.272704401 | 5.28 | 2.942 | G | 3 |
63 | Q | GLN | 100 | 0.455425776 | 4.805 | 2.868 | G | 2 |
64 | L | LEU | 99.2 | 0.429322722 | 3.185 | 1.884 | C | 2 |
65 | E | GLU | 100 | 0.455425776 | 4.029 | 2.115 | C | 2 |
66 | Q | GLN | 94.4 | 0.272704401 | 4.204 | 3.445 | C | 4 |
67 | P | PRO | 100 | 0.455425776 | 3.723 | 2.711 | C | 10 |
68 | Y | TYR | 100 | 0.455425776 | 3.482 | 2.216 | E | 7 |
69 | V | VAL | 99.6 | 0.442374249 | 2.863 | 1.793 | E | 8 |
70 | F | PHE | 100 | 0.455425776 | 2.586 | 1.86 | E | 3 |
71 | I | ILE | 99.2 | 0.429322722 | 2.736 | 1.583 | E | 2 |
72 | K | LYS | 100 | 0.455425776 | 3.485 | 2.408 | E | 2 |
73 | R | ARG | 100 | 0.455425776 | 3.634 | 2.224 | C | 1 |
74 | S | SER | 99.6 | 0.442374249 | 5.23 | 1.987 | C | 0 |
75 | D | ASP | 93.6 | 0.246601347 | 6.282 | 3.04 | C | 0 |
76 | A | ALA | 100 | 0.455425776 | 8.704 | 3.228 | C | 0 |
77 | R | ARG | 14 | -2.350652479 | 8.377 | 3.022 | C | 0 |
78 | T | THR | 14.4 | -2.337600953 | 7.188 | 3.598 | C | 0 |
79 | A | ALA | 14.4 | -2.337600953 | 7.081 | 2.87 | C | 0 |
80 | P | PRO | 14 | -2.350652479 | 6.444 | 3.444 | C | 0 |
81 | H | HIS | 100 | 0.455425776 | 7.835 | 4.051 | C | 1 |
82 | G | GLY | 98.4 | 0.403219669 | 7.854 | 3.077 | C | 1 |
83 | H | HIS | 98.8 | 0.416271195 | 5.596 | 2.63 | C | 0 |
84 | V | VAL | 14 | -2.350652479 | 4.175 | 2.08 | E | 0 |
85 | M | MET | 14 | -2.350652479 | 4.414 | 2.089 | E | 0 |
86 | V | VAL | 95.2 | 0.298807454 | 4.023 | 1.397 | E | 0 |
87 | E | GLU | 100 | 0.455425776 | 4.224 | 1.768 | E | 1 |
88 | L | LEU | 100 | 0.455425776 | 3.776 | 1.936 | E | 2 |
89 | V | VAL | 100 | 0.455425776 | 4.265 | 2.449 | E | 5 |
90 | A | ALA | 100 | 0.455425776 | 4.563 | 2.737 | E | 8 |
91 | E | GLU | 100 | 0.455425776 | 4.878 | 3.084 | E | 7 |
92 | L | LEU | 39.6 | -1.515354766 | 5.603 | 3.709 | C | 9 |
93 | E | GLU | 13.2 | -2.376755533 | 5.816 | 3.963 | C | 6 |
94 | G | GLY | 100 | 0.455425776 | 4.225 | 3.123 | C | 5 |
95 | I | ILE | 94 | 0.259652874 | 5.046 | 4.119 | C | 5 |
96 | Q | GLN | 99.6 | 0.442374249 | 4.626 | 3.922 | C | 6 |
97 | Y | TYR | 86.4 | 0.011673866 | 3.777 | 2.983 | T | 7 |
98 | G | GLY | 100 | 0.455425776 | 3.24 | 2.773 | T | 7 |
99 | R | ARG | 100 | 0.455425776 | 4.368 | 4.195 | T | 6 |
100 | S | SER | 100 | 0.455425776 | 4.254 | 3.136 | T | 6 |
101 | G | GLY | 100 | 0.455425776 | 3.629 | 3.029 | C | 4 |
102 | E | GLU | 14.4 | -2.337600953 | 3.63 | 2.66 | C | 4 |
103 | T | THR | 99.6 | 0.442374249 | 2.594 | 2.144 | C | 5 |
104 | L | LEU | 100 | 0.455425776 | 2.082 | 1.976 | E | 1 |
105 | G | GLY | 100 | 0.455425776 | 1.852 | 1.475 | E | 1 |
106 | V | VAL | 100 | 0.455425776 | 1.494 | 1.516 | E | 0 |
107 | L | LEU | 100 | 0.455425776 | 1.538 | 1.523 | E | 0 |
108 | V | VAL | 100 | 0.455425776 | 1.678 | 1.32 | E | 0 |
109 | P | PRO | 100 | 0.455425776 | 2.048 | 1.906 | E | 2 |
110 | H | HIS | 99.2 | 0.429322722 | 2.261 | 2.571 | C | 4 |
111 | V | VAL | 99.2 | 0.429322722 | 3.247 | 3.537 | C | 5 |
112 | G | GLY | 99.6 | 0.442374249 | 3.674 | 3.367 | C | 3 |
113 | E | GLU | 100 | 0.455425776 | 3.641 | 2.723 | C | 2 |
114 | I | ILE | 12.4 | -2.402858586 | 4.589 | 3.838 | C | 3 |
115 | P | PRO | 100 | 0.455425776 | 4.153 | 3.247 | C | 7 |
116 | V | VAL | 14.4 | -2.337600953 | 4.989 | 3.574 | E | 6 |
117 | A | ALA | 98.4 | 0.403219669 | 4.756 | 3.548 | E | 6 |
118 | Y | TYR | 100 | 0.455425776 | 4.327 | 3.625 | E | 7 |
119 | R | ARG | 100 | 0.455425776 | 4.294 | 2.977 | E | 5 |
120 | K | LYS | 14.4 | -2.337600953 | 4.73 | 3.55 | E | 4 |
121 | V | VAL | 100 | 0.455425776 | 4.766 | 2.026 | E | 1 |
122 | L | LEU | 100 | 0.455425776 | 5.43 | 2.048 | E | 0 |
123 | L | LEU | 99.2 | 0.429322722 | 5.461 | 1.92 | E | 2 |
124 | R | ARG | 100 | 0.455425776 | 5.87 | 2.4 | C | 2 |
125 | K | LYS | 100 | 0.455425776 | 6.23 | 3.411 | C | 2 |
126 | N | ASN | 99.2 | 0.429322722 | 6.528 | 3.371 | C | 1 |
127 | G | GLY | 100 | 0.455425776 | 4.859 | 2.463 | C | 0 |
128 | N | ASN | 100 | 0.455425776 | 2.629 | 2.9 | C | 0 |
129 | K | LYS | 100 | 0.455425776 | 4.018 | 2.985 | C | 0 |
130 | G | GLY | 98.8 | 0.416271195 | 5.142 | 2.464 | C | 0 |
131 | A | ALA | 100 | 0.455425776 | 4.786 | 3.334 | C | 0 |
132 | G | GLY | 100 | 0.455425776 | 4.565 | 3.283 | C | 0 |
133 | G | GLY | 100 | 0.455425776 | 7.066 | 3.882 | T | 0 |
134 | H | HIS | 100 | 0.455425776 | 10.158 | 5.474 | T | 0 |
135 | S | SER | 99.2 | 0.429322722 | 8.491 | 4.808 | T | 0 |
136 | Y | TYR | 76.8 | -0.301562777 | 9.578 | 4.689 | T | 0 |
137 | G | GLY | 100 | 0.455425776 | 11.549 | 4.329 | C | 0 |
138 | A | ALA | 14.4 | -2.337600953 | 11.633 | 4.931 | C | 0 |
139 | D | ASP | 100 | 0.455425776 | 11.707 | 4.98 | C | 1 |
140 | L | LEU | 100 | 0.455425776 | 13.2 | 5.894 | C | 2 |
141 | K | LYS | 96.8 | 0.351013562 | 12.36 | 5.953 | C | 2 |
142 | S | SER | 99.2 | 0.429322722 | 13.244 | 4.392 | C | 2 |
143 | F | PHE | 13.2 | -2.376755533 | 10.038 | 3.528 | C | 2 |
144 | D | ASP | 100 | 0.455425776 | 9.611 | 3.808 | C | 2 |
145 | L | LEU | 100 | 0.455425776 | 8.294 | 4.457 | C | 2 |
146 | G | GLY | 100 | 0.455425776 | 6.479 | 4.715 | T | 3 |
147 | D | ASP | 98.8 | 0.416271195 | 6.73 | 5.713 | T | 4 |
148 | E | GLU | 96.4 | 0.337962035 | 9.59 | 5.356 | T | 3 |
149 | L | LEU | 100 | 0.455425776 | 5.291 | 3.677 | T | 6 |
150 | G | GLY | 94.8 | 0.285755928 | 8.299 | 4.462 | C | 4 |
151 | T | THR | 100 | 0.455425776 | 10.767 | 4.742 | C | 4 |
152 | D | ASP | 100 | 0.455425776 | 7.066 | 3.879 | C | 4 |
153 | P | PRO | 99.2 | 0.429322722 | 4.575 | 3.915 | C | 2 |
154 | Y | TYR | 12.8 | -2.38980706 | 5.264 | 4.089 | C | 3 |
155 | E | GLU | 99.6 | 0.442374249 | 3.771 | 3.24 | H | 3 |
156 | D | ASP | 100 | 0.455425776 | 3.818 | 3.876 | H | 1 |
157 | F | PHE | 14 | -2.350652479 | 4.062 | 4.108 | H | 2 |
158 | Q | GLN | 14 | -2.350652479 | 3.455 | 2.955 | H | 0 |
159 | E | GLU | 13.6 | -2.363704006 | 3.943 | 3.091 | H | 1 |
160 | N | ASN | 93.2 | 0.233549821 | 4.034 | 3.364 | H | 1 |
161 | W | TRP | 100 | 0.455425776 | 5.654 | 4.048 | H | 1 |
162 | N | ASN | 100 | 0.455425776 | 6.553 | 3.448 | C | 2 |
163 | T | THR | 100 | 0.455425776 | 6.726 | 4.14 | H | 2 |
164 | K | LYS | 100 | 0.455425776 | 7.7 | 4.912 | H | 2 |
165 | H | HIS | 100 | 0.455425776 | 6.645 | 4.162 | H | 2 |
166 | S | SER | 12.8 | -2.38980706 | 5.928 | 3.871 | H | 3 |
167 | S | SER | 95.2 | 0.298807454 | 6.244 | 4.62 | H | 3 |
168 | G | GLY | 100 | 0.455425776 | 8.119 | 4.558 | H | 2 |
169 | V | VAL | 29.2 | -1.854694462 | 8.524 | 4.344 | H | 4 |
170 | T | THR | 13.6 | -2.363704006 | 7.337 | 4.557 | H | 5 |
171 | R | ARG | 100 | 0.455425776 | 8.57 | 6.01 | H | 7 |
172 | E | GLU | 98.8 | 0.416271195 | 10.97 | 5.582 | H | 6 |
173 | L | LEU | 100 | 0.455425776 | 11.013 | 5.524 | H | 8 |
174 | M | MET | 12.8 | -2.38980706 | 10.121 | 5.981 | H | 7 |
175 | R | ARG | 100 | 0.455425776 | 12.342 | 6.805 | H | 7 |
176 | E | GLU | 100 | 0.455425776 | 14.528 | 6.742 | H | 6 |
177 | L | LEU | 100 | 0.455425776 | 14.115 | 6.876 | H | 5 |
178 | N | ASN | 100 | 0.455425776 | 15.866 | 7.296 | C | 6 |
179 | G | GLY | 100 | 0.455425776 | 20.436 | 8.047 | C | 5 |
180 | G | GLY | 100 | 0.455425776 | 25.093 | 9.249 | C | 1 |
2. I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/
3. Cui H, Gao Z, Liu M, et al. Structural Genomics and Interactomics of 2019 Wuhan Novel Coronavirus, SARS-CoV-2, Indicate Evolutionary Conserved Functional Regions of Viral Proteins. 2020 [cited 2020 Apr 10];Available from: https://www.preprints.org/manuscript/202002.0372/v1