Guanine-N7_methyltransferase Google Drive Data

Gray amino acids fall below the average conservation (value <0) for each protein, yellow = 0-0.5, light orange = 0.5-1, orange = 1-1.5, dark orange = 1.5-2, red = >2

Guanine-N7 methyltransferase (ExoN) (nsp14)– ExoN has exoribonuclease activity acting on both ssRNA and dsRNA in a 3′ to 5′ direction, and it has N7-guanine methyltransferase activity as well.2 It interacts with nsp10.4

nsp14 interacting with nsp10 showing a conserved binding interface

Guanine-N7 methyltransferase 2,794 Sequences

Amino AcidAAAAConservationConservation Z-scoreRMSD_CARMSF[A]Secondary StructureDCCM >0.9
5926AALA8.339298497-1.37580497710.43210.477C1
5927EGLU9.914101646-1.3267071227.9578.608C2
5928NASN12.06156049-1.2597555025.3726.149C2
5929VVAL25.62634216-0.8368444354.3074.23C1
5930TTHR55.619183970.0982465273.1313.028C0
5931GGLY71.617752330.5970360974.0991.953T0
5932LLEU88.904795991.1359966393.1021.724T0
5933FPHE88.296349321.1170270143.5661.79T0
5934KLYS88.869005011.1348807794.5582.645T0
5935DASP66.893342880.4497425333.8741.301C0
5936CCYS88.869005011.1348807793.6881.357C1
5937SSER61.48890480.2812476223.4851.261C1
5938KLYS41.51753758-0.3414024463.3211.992C0
5939VVAL2.863278454-1.5465316092.8482.328C0
5940IILE9.126700072-1.351256054.5333.341C0
5941TTHR7.659269864-1.3970063244.9422.714C0
5942GGLY55.225483180.0859720635.8462.645C0
5943LLEU52.25483178-0.0066443455.8262.893E1
5944HHIS39.22691482-0.4128175076.8594.071T6
5945PPRO88.869005011.1348807798.1634.949T8
5946TTHR9.55619184-1.3378657267.9675.608T3
5947QGLN7.516105941-1.4014697657.054.073T4
5948AALA88.582677171.1259538967.3114.201C3
5949PPRO39.04795991-0.4183968098.5664.751C3
5950TTHR75.304223340.71196971210.3846.328T3
5951HHIS7.337151038-1.40704906710.8527.557T4
5952LLEU25.16105941-0.85135061910.8157.792T4
5953SSER54.115962780.0513803938.434.83E2
5954VVAL36.97208304-0.4831167087.5274.498E4
5955DASP36.64996421-0.4931594516.6863.519E2
5956TTHR4.724409449-1.4885068718.2984.792T1
5957KLYS38.18897638-0.4451774577.3114.403T1
5958FPHE40.98067287-0.3581403518.354.141T7
5959KLYS84.502505370.99874581811.1016.324C6
5960TTHR54.903364350.0759293212.5086.903C7
5961EGLU11.27415891-1.2843044315.0958.363C6
5962GGLY24.91052255-0.85916164214.5827.877C5
5963LLEU88.546886181.12483803613.6888.643C8
5964CCYS23.80100215-0.89375331211.0986.653C8
5965VVAL69.398711520.52785275610.936.693C7
5966DASP7.516105941-1.4014697659.4035.934C4
5967IILE38.61846815-0.4317871339.445.615T3
5968PPRO7.802433787-1.3925428829.8086.699T3
5969GGLY7.587687903-1.3992380449.4376.111T4
5970IILE8.052970651-1.384731867.7474.695T3
5971PPRO22.69148175-0.9283449827.8024.892C3
5972KLYS11.59627774-1.2742616878.1595.488C2
5973DASP12.20472441-1.2552920617.8633.934C1
5974MMET8.017179671-1.385847727.1534.51C1
5975TTHR40.08589835-0.3860368595.9812.943C2
5976YTYR88.618468151.1270697575.1241.969C2
5977RARG7.516105941-1.4014697654.5642.506C1
5978RARG37.25841088-0.4741898263.2331.625E0
5979LLEU40.65855404-0.3681830942.4491.674E0
5980IILE82.462419470.9351417792.2581.569C0
5981SSER88.546886181.1248380362.4771.247C0
5982MMET7.587687903-1.3992380442.0941.416C0
5983MMET69.792412310.540127222.251.612C0
5984GGLY89.047959911.1404600812.261.601C0
5985FPHE89.012168931.139344221.8391.855C0
5986KLYS52.43378669-0.0010650431.9343.175C0
5987MMET22.11882606-0.9461987482.1092.266C0
5988NASN7.695060845-1.3958904633.723.531C0
5989YTYR7.551896922-1.4003539054.5163.736C2
5990QGLN7.408732999-1.4048173467.2266.113C2
5991VVAL40.90909091-0.3603720717.8946.34T3
5992NASN7.408732999-1.4048173468.1576.996T3
5993GGLY61.739441660.2890586448.2255.993T2
5994YTYR47.9599141-0.1405475856.4384.901T3
5995PPRO23.12097351-0.9149546584.2683.715C2
5996NASN26.55690766-0.8078320663.4322.355C1
5997MMET26.6642806-0.8044844852.9931.841C0
5998FPHE88.976377951.138228362.912.392C1
5999IILE52.00429492-0.0144553672.9611.295C2
6000TTHR89.012168931.139344223.0471.481H2
6001RARG75.876879030.7298234772.9612.371H2
6002EGLU35.0035791-0.5444890272.5241.792H2
6003EGLU50.78740157-0.0523946192.4071.436H2
6004AALA84.931997141.0121361422.4881.232H2
6005IILE30.10021475-0.6973618932.2791.392H2
6006RARG70.722977810.5691395891.8211.747H2
6007HHIS11.45311382-1.2787251281.7961.335T2
6008VVAL88.904795991.1359966391.7241.307T2
6009RARG84.860415181.0099044211.3981.139T2
6010AALA23.3357194-0.9082594961.6171.122E2
6011WTRP89.012168931.139344221.5551.061E2
6012IILE30.45812455-0.686203291.4941.301E1
6013GGLY89.047959911.1404600811.7511.049E1
6014FPHE78.131710810.8001226781.921.111E2
6015DASP88.188976381.1136794332.0491.159E1
6016VVAL77.165354330.7699944491.4891.382E1
6017EGLU88.188976381.1136794331.271.544E2
6018GGLY67.179670720.4586694151.6261.184E2
6019CCYS7.408732999-1.4048173461.9741.222E2
6020HHIS89.012168931.139344221.9581.951E2
6021AALA56.12025770.1138685712.0381.483E1
6022TTHR22.4051539-0.9372718653.4942.051C0
6023RARG30.95919828-0.6705812453.0483.051C0
6024EGLU4.330708661-1.5007813352.431.98C0
6025AALA23.01360057-0.9183022392.4531.482C0
6026VVAL35.28990694-0.5355621444.9531.954C0
6027GGLY88.976377951.138228362.7781.601C0
6028TTHR89.012168931.139344222.0991.339E1
6029NASN88.940586971.13711252.081.633E1
6030LLEU28.20329277-0.7565024911.1321.153E0
6031PPRO88.904795991.1359966391.1211.051E0
6032LLEU74.123120970.6751463211.2581.342E1
6033QGLN88.725841091.1304173381.2961.467E3
6034LLEU60.701503220.2566986941.2331.422E3
6035GGLY89.012168931.139344221.3131.072E3
6036FPHE88.976377951.138228361.3431.097E5
6037SSER89.012168931.139344221.4441.204C3
6038TTHR55.762347890.1027099681.5981.436C4
6039GGLY88.904795991.1359966391.7221.425C3
6040VVAL57.193987120.1473443821.2061.433E4
6041NASN30.10021475-0.6973618931.2421.321E4
6042LLEU7.480314961-1.4025856251.4121.306E3
6043VVAL82.999284180.9518796841.4021.369E3
6044AALA9.413027917-1.3423291671.2111.238E2
6045VVAL7.695060845-1.3958904631.4091.292E2
6046PPRO69.720830350.5378954991.3571.122E2
6047TTHR20.365068-1.0008759041.2231.069E2
6048GGLY88.260558341.1159111531.4150.964E0
6049YTYR7.98138869-1.3869635811.6711.197E0
6050VVAL67.108088760.4564376952.7621.539E0
6051DASP38.40372226-0.4384822952.7781.284E0
6052TTHR70.150322120.5512858234.2611.621E1
6053PPRO2.541159628-1.5565743524.9912.215C1
6054NASN8.231925555-1.3791525585.362.471E1
6055NASN7.587687903-1.3992380444.4511.861E2
6056TTHR8.303507516-1.3769208383.3761.637E1
6057DASP2.326413744-1.5632695143.6541.34E0
6058FPHE35.50465283-0.5288669821.5381.16E0
6059SSER2.505368647-1.5576902121.4941.252E1
6060RARG7.695060845-1.3958904631.4562.037E3
6061VVAL60.021474590.2354973481.4861.317E2
6062SSER3.042233357-1.5409523071.8121.579E1
6063AALA71.939871150.607078841.5571.44E0
6064KLYS41.08804581-0.354792772.6122.544E0
6065PPRO22.94201861-0.920533963.2612.069C0
6066PPRO88.582677171.1259538963.5992.209C1
6067PPRO88.797423051.1326490584.5392.748C2
6068GGLY88.725841091.1304173385.1192.673T2
6069DASP10.45096636-1.3099692174.8223.019T1
6070QGLN87.687902651.0980573885.1753.043T1
6071FPHE89.298496781.1482711034.4032.175T2
6072KLYS39.40586972-0.4072382064.2323.528G1
6073HHIS95.239799571.3335039194.2452.449G1
6074LLEU94.702934861.3167660143.3111.882G2
6075IILE30.02863278-0.6995936142.7622.071G2
6076PPRO76.521116680.7499089632.7151.839T2
6077LLEU91.338582681.2118751422.4281.688T2
6078MMET50.78740157-0.0523946192.1491.941T2
6079YTYR7.516105941-1.4014697652.3962.274T1
6080KLYS41.94702935-0.3280121222.7892.659C0
6081GGLY76.342161780.7443296612.211.425C1
6082LLEU7.480314961-1.4025856251.6211.495E2
6083PPRO64.06585540.3615895661.1251.311H2
6084WTRP95.74087331.3491259640.9931.099H4
6085NASN8.697208304-1.3646463741.21.532H2
6086VVAL70.830350750.572487171.2371.388H3
6087VVAL76.270579810.7420979411.0871.223H3
6088RARG95.776664281.3502418241.0271.591H2
6089IILE9.914101646-1.3267071221.241.736H4
6090KLYS7.659269864-1.3970063241.2551.549H4
6091IILE95.347172511.33685151.1091.196H6
6092VVAL91.553328561.2185703041.2121.403H5
6093QGLN87.795275591.1014049691.3571.769H9
6094MMET91.553328561.2185703041.3071.437H8
6095LLEU44.55977094-0.2465543171.2311.296H8
6096SSER53.543307090.0335266271.3641.584H9
6097DASP91.517537581.2174544441.5231.739H7
6098TTHR24.15891195-0.8825947091.5271.523H7
6099LLEU87.40157481.0891305051.4791.492T9
6100KLYS9.198282033-1.3490243291.6062.267T7
6101NASN43.19971367-0.288957012.4152.351T3
6102LLEU70.794559770.5713713091.5691.994T3
6103SSER89.012168931.139344221.5481.385C2
6104DASP94.738725841.3178818741.9361.427C2
6105RARG7.838224767-1.3914270221.9741.247C2
6106VVAL41.44595562-0.3436341661.641.162E2
6107VVAL42.84180387-0.3001156131.8421.095E2
6108FPHE83.464566930.9663858682.0271.022E1
6109VVAL95.132426631.3301563382.0881.122E1
6110LLEU44.52397996-0.2476701772.4511.213E1
6111WTRP95.705082321.3480101032.131.369C0
6112AALA76.020042950.7342869182.1321.567C0
6113HHIS45.41875447-0.2197736693.9172.437H1
6114GGLY75.769506080.7264758964.2251.732H1
6115FPHE39.04795991-0.4183968093.9282.589H0
6116EGLU95.812455261.3513576844.8112.216H0
6117LLEU95.633500361.3457783823.3531.961H0
6118TTHR91.231209741.2085275611.4821.189H0
6119SSER22.87043665-0.9227656811.5381.162H0
6120MMET49.67788117-0.0869862892.2571.404H0
6121KLYS8.410880458-1.3735732572.2461.466C0
6122YTYR96.420901931.370327311.7741.147C1
6123FPHE96.456692911.371443171.7631.027E1
6124VVAL65.032211880.3917177952.451.254E1
6125KLYS95.382963491.337967363.1532.29E3
6126IILE71.045096640.5791823323.4152.196C2
6127GGLY96.778811741.3814859133.5392.04C3
6128PPRO37.25841088-0.4741898263.1592.13C2
6129EGLU57.516105940.1573871252.3022.183C2
6130RARG11.05941303-1.2909995922.172.287C6
6131TTHR12.63421618-1.2419017372.3312.292C12
6132CCYS96.456692911.371443172.2822.099C15
6133CCYS22.83464567-0.9238815412.3112.353C12
6134LLEU7.480314961-1.4025856252.4542.886C10
6135CCYS95.526127421.3424308012.52.481C11
6136DASP7.408732999-1.4048173462.6862.77C10
6137RARG24.33786686-0.8770154072.4482.262C11
6138RARG62.312097350.306912412.2052.486C8
6139AALA94.81030781.3201135951.9441.768C13
6140TTHR73.299928420.6494815331.6531.471E7
6141CCYS47.45884037-0.156169631.9181.574E12
6142FPHE24.58840372-0.8692043852.3751.67E10
6143SSER27.4158912-0.7810514182.3241.804E9
6144TTHR7.480314961-1.4025856252.4772.165C4
6145AALA23.37151038-0.9071436363.5372.391C3
6146SSER12.41947029-1.2485968994.1532.684C5
6147DASP7.945597709-1.3880794414.012.756C2
6148TTHR32.67716535-0.6170199493.4742.369E5
6149YTYR85.254115961.0221788852.5642.029E11
6150AALA45.59770938-0.2141943672.2281.919E17
6151CCYS95.490336441.3413149411.7651.833T17
6152WTRP54.115962780.0513803931.6941.548T8
6153HHIS2.505368647-1.5576902122.0242.18T9
6154HHIS95.418754471.339083222.3612.257T10
6155SSER37.43736578-0.4686105242.0841.999T7
6156IILE2.290622763-1.5643853742.9472.483T4
6157GGLY77.093772370.7677627282.9611.885T1
6158FPHE22.5841088-0.9316925632.4521.785T5
6159DASP95.239799571.3335039192.7221.611C4
6160YTYR79.384395130.839177792.4871.74E5
6161VVAL50.03579098-0.0758276862.0431.38E3
6162YTYR95.311381531.3357356392.6431.547E5
6163NASN96.062992131.3591687073.0031.367C1
6164PPRO92.197566211.238655792.3261.289C0
6165FPHE31.8539728-0.6426847362.4311.092E1
6166MMET7.516105941-1.4014697652.6541.468E1
6167IILE45.23979957-0.2253529712.8611.261E0
6168DASP90.264853261.1783993323.1891.45E0
6169VVAL31.74659986-0.6460323173.1871.325G0
6170QGLN85.218324981.0210630252.961.802G0
6171QGLN84.25196850.9909347964.0372.47G1
6172WTRP88.439513241.1214904554.411.735G2
6173GGLY86.506800291.0612339973.9251.829C1
6174FPHE11.30994989-1.2831885692.6951.63C0
6175TTHR20.75876879-0.9886014414.1662.686C0
6176GGLY88.51109521.1237221762.7011.996C0
6177NASN38.72584109-0.4284395522.9771.833H3
6178LLEU89.692197571.1605455672.5771.427H3
6179QGLN23.5146743-0.9026801952.5791.842H4
6180SSER23.1567645-0.9138387982.9191.695H4
6181NASN88.439513241.1214904553.0041.431H2
6182HHIS89.62061561.1583138462.741.18H3
6183DASP56.764495350.1339540582.9051.549H1
6184LLEU25.94846099-0.8268016922.2491.641H1
6185YTYR29.02648533-0.7308377032.0391.416C1
6186CCYS89.763779531.1627772871.9681.156C0
6187QGLN8.375089477-1.3746891172.632.043C0
6188VVAL74.552612740.6885366453.2861.582C1
6189HHIS89.763779531.1627772873.3831.194C1
6190GGLY23.76521117-0.8948691724.1421.505C0
6191NASN44.6313529-0.2443225964.3242.045C0
6192AALA56.335003580.1205637333.8651.739C1
6193HHIS89.799570511.1638931484.7142.751C2
6194VVAL86.327845381.0556546953.2761.812C2
6195AALA89.763779531.1627772872.7071.409H1
6196SSER88.654259131.1281856172.1331.349H2
6197CCYS9.01932713-1.3546036312.421.649H2
6198DASP89.799570511.1638931482.471.388H2
6199AALA90.909090911.1984848182.181.256H2
6200IILE84.717251251.005440982.2681.561H1
6201MMET91.159627771.206295842.351.527H2
6202TTHR91.123836791.205179982.5851.42H2
6203RARG85.862562631.0411485113.5311.431H2
6204CCYS91.195418751.2074117013.6991.221H2
6205LLEU90.980672871.2007165392.8721.51H2
6206AALA90.050107371.171704172.551.281H2
6207VVAL25.7337151-0.8334968542.6511.375H2
6208HHIS55.5476020.0960148062.7371.365H2
6209EGLU11.81102362-1.2675665252.1681.438H2
6210CCYS71.188260560.5836457731.6871.223H2
6211FPHE90.121689331.1739358911.6081.266C2
6212VVAL42.16177523-0.321316962.581.641C1
6213KLYS52.18324982-0.0088760663.6482.749C1
6214RARG28.16750179-0.7576183513.3222.462C2
6215VVAL79.455977090.8414095113.3031.944C2
6216DASP59.949892630.2332656273.5981.95T3
6217WTRP90.157480311.1750517512.9462.46T3
6218TTHR4.581245526-1.4929703133.1272.056T3
6219IILE49.78525412-0.0836387082.2781.755T3
6220EGLU39.76377953-0.3960796021.91.66C2
6221YTYR86.005726561.0456119521.3361.468C2
6222PPRO90.085898351.172820031.4381.617C2
6223IILE21.61775233-0.9618207931.5952.132C1
6224IILE85.93414461.0433802311.4792.014C0
6225GGLY27.88117394-0.7665452341.6851.611C0
6226DASP7.659269864-1.3970063242.0632.033H0
6227EGLU85.898353611.0422643711.6151.458H0
6228LLEU18.53972799-1.0577847811.8861.911H0
6229KLYS24.19470293-0.8814788481.3761.831H1
6230IILE51.39584825-0.0334249931.2321.339H1
6231NASN90.050107371.171704171.2951.52H1
6232AALA4.187544739-1.5052447761.221.18H1
6233AALA18.39656407-1.0622482231.1981.163H1
6234CCYS55.726556910.1015941081.2341.267H1
6235RARG90.085898351.172820031.151.92H0
6236KLYS7.480314961-1.4025856251.2151.665H0
6237VVAL61.453113820.2801317621.1611.034H0
6238QGLN74.481030780.6863049241.2370.944H0
6239HHIS7.44452398-1.4037014861.3651.07H0
6240MMET22.65569077-0.9294608431.5281.096H0
6241VVAL33.21403006-0.6002820441.3331.038H0
6242VVAL26.02004295-0.8245699711.5891.09H1
6243KLYS24.58840372-0.8692043851.9111.417H2
6244AALA59.520400860.2198753031.9251.148H1
6245AALA48.78310666-0.1148827971.9721.236H0
6246LLEU56.764495350.1339540582.3871.325H0
6247LLEU35.79098067-0.5199400992.5521.498H0
6248AALA37.79527559-0.4574519212.6151.576H0
6249DASP7.480314961-1.4025856252.8471.54H1
6250KLYS29.27702219-0.7230266813.0792.139C2
6251FPHE22.61989979-0.9305767033.151.841C3
6252PPRO6.871868289-1.4215552513.5771.673E3
6253VVAL29.88546886-0.7040570553.3761.84E9
6254LLEU7.408732999-1.4048173462.7441.542E10
6255HHIS26.30637079-0.8156430892.9291.331E8
6256DASP90.050107371.171704172.3881.15E8
6257IILE82.856120260.9474162432.9551.414E5
6258GGLY90.085898351.172820033.4471.214E3
6259NASN90.050107371.171704172.7441.276C3
6260PPRO90.121689331.1739358913.0391.507C4
6261KLYS90.050107371.171704173.1422.007C5
6262AALA13.24266285-1.2229321113.041.671C2
6263IILE84.681460271.004325122.3682.026C3
6264KLYS22.87043665-0.9227656812.2011.592C2
6265CCYS69.756621330.539011361.891.397C2
6266VVAL56.47816750.1250271751.791.342T2
6267PPRO7.408732999-1.4048173462.4011.576T1
6268QGLN7.408732999-1.4048173462.7881.809T1
6269AALA8.160343593-1.3813842793.2781.655T2
6270DASP55.690765930.1004782473.391.897C1
6271VVAL37.36578382-0.4708422452.9841.517C5
6272EGLU8.5182534-1.3702256763.1721.725E5
6273WTRP57.551896920.1585029852.6231.356E8
6274KLYS21.61775233-0.9618207933.1021.938E7
6275FPHE41.08804581-0.354792773.0441.438E9
6276YTYR56.370794560.1216795943.3481.436E8
6277DASP90.121689331.1739358913.6451.521E8
6278AALA35.46886185-0.5299828424.4291.827C2
6279QGLN37.07945598-0.4797691274.4632.219C3
6280PPRO90.121689331.1739358913.171.968C3
6281CCYS7.408732999-1.4048173462.9282.126C4
6282SSER8.052970651-1.384731862.6082.41T2
6283DASP8.088761632-1.3836162.92.497T2
6284KLYS7.44452398-1.4037014863.1032.876T1
6285AALA7.480314961-1.4025856252.9832.228T1
6286YTYR7.372942019-1.4059332062.9892.588C3
6287KLYS21.97566213-0.9506621892.9762.598E2
6288IILE7.372942019-1.4059332063.3431.745E5
6289EGLU7.659269864-1.3970063243.7341.94E5
6290EGLU7.730851825-1.3947746034.0812.013E4
6291LLEU72.727272730.6316277674.3362.059E1
6292FPHE24.37365784-0.8758995475.2853.03C1
6293YTYR90.121689331.1739358914.5081.552C2
6294SSER17.0365068-1.1046509164.8741.745T2
6295YTYR60.594130280.2533511134.5531.516T4
6296AALA9.55619184-1.3378657265.8232.037T2
6297TTHR35.11095204-0.5411414465.4472.073T3
6298HHIS70.329277020.5568651254.5961.854T3
6299SSER16.57122405-1.11915714.3451.781T1
6300DASP35.79098067-0.5199400994.4841.973T1
6301KLYS21.97566213-0.9506621894.6182.459T2
6302FPHE55.762347890.1027099683.7281.759C3
6303TTHR10.95204009-1.2943471733.8821.816C2
6304DASP81.746599860.9128245723.6751.825C3
6305GGLY90.121689331.1739358913.3011.453C4
6306VVAL7.408732999-1.4048173462.6211.517E5
6307CCYS78.954903360.8257874662.5251.157E4
6308LLEU57.301360060.1506919632.0621.116E4
6309FPHE90.157480311.1750517512.1641.043E1
6310WTRP90.085898351.172820031.8781.343E0
6311NASN90.085898351.172820032.0191.219E0
6312CCYS90.050107371.171704172.381.192C0
6313NASN90.19327131.1761676113.2591.305C0
6314VVAL90.157480311.1750517513.8441.374C0
6315DASP73.15676450.6450180912.8121.483C1
6316RARG8.339298497-1.3758049772.8651.348C2
6317YTYR90.19327131.1761676112.3740.997C2
6318PPRO90.157480311.1750517512.521.245C4
6319AALA12.956335-1.2318589942.4921.408C5
6320NASN55.905511810.1071734092.6491.247E4
6321SSER52.720114530.007861842.4841.04E4
6322IILE35.32569792-0.5344462841.7471.074E2
6323VVAL90.157480311.1750517511.8241.012E1
6324CCYS90.19327131.1761676111.7590.829E0
6325RARG90.050107371.171704171.8721.223E1
6326FPHE71.080887620.5802981922.1161.052C1
6327DASP90.085898351.172820032.2971.072T0
6328TTHR90.085898351.172820032.2291.114T0
6329RARG85.719398711.0366850692.3521.905T1
6330VVAL37.15103794-0.4775374072.2391.454T1
6331LLEU36.47100931-0.4987387533.0042.62C0
6332SSER73.120973510.6439022312.6771.478T0
6333NASN18.1460272-1.0700592452.211.78T0
6334LLEU53.292770220.0257156052.1341.563T0
6335NASN79.169649250.8324826282.021.126T0
6336LLEU90.014316391.170588312.7681.702E0
6337PPRO51.03793844-0.0445835963.0481.287C0
6338GGLY90.014316391.170588312.3851.1C0
6339CCYS79.062276310.8291350472.5241.357T1
6340DASP21.93987115-0.951778052.2651.147T1
6341GGLY88.546886181.1248380362.041.104T0
6342GGLY84.466714390.9976299582.3031.007T1
6343SSER79.133858270.8313667682.1761.055E2
6344LLEU88.439513241.1214904551.9281.24E3
6345YTYR88.546886181.1248380361.8011.138E1
6346VVAL88.367931281.1192587341.6521.793E1
6347NASN88.582677171.1259538961.4521.27C1
6348KLYS58.410880460.1852836332.411.824C0
6349HHIS88.546886181.1248380361.8071.54E0
6350AALA88.51109521.1237221762.0281.405E1
6351FPHE88.582677171.1259538962.0621.814E2
6352HHIS83.929849680.9808920532.0651.118E2
6353TTHR88.475304221.1226063152.5421.109E0
6354PPRO74.087329990.674030462.6531.126C0
6355AALA55.762347890.1027099682.3851.226C0
6356FPHE58.231925550.1797043312.8011.477C0
6357DASP69.148174660.5200417342.7191.364T0
6358KLYS36.14889048-0.5087814963.0542.197T0
6359SSER23.12097351-0.9149546583.0011.398T1
6360AALA72.190408020.6148898622.7561.197T2
6361FPHE81.925554760.9184038742.4231.116T2
6362VVAL5.046528275-1.4784641282.7421.438T3
6363NASN25.66213314-0.8357285752.5891.335T3
6364LLEU88.51109521.1237221762.0671.223T6
6365KLYS83.750894770.9753127511.6151.339E2
6366QGLN8.303507516-1.3769208381.4111.793E2
6367LLEU23.72942019-0.8959850331.3021.095C1
6368PPRO88.367931281.1192587341.2741.189C1
6369FPHE84.430923410.9965140971.4121.175C2
6370FPHE84.323550470.9931665161.8031.101C2
6371YTYR49.17680744-0.1026083342.0821.121E1
6372YTYR85.075161061.0165995832.1751.21E0
6373SSER40.58697208-0.3704148142.0421.266E1
6374DASP52.648532570.0056301192.3681.604C2
6375SSER31.1023622-0.6661178032.4741.653C3
6376PPRO52.43378669-0.0010650432.9191.936C2
6377CCYS88.439513241.1214904553.3791.751C5
6378EGLU44.20186113-0.257712924.1592.091C6
6379SSER11.56048676-1.2753775475.4262.39C5
6380HHIS22.33357194-0.9395035865.2222.1C5
6381GGLY22.44094488-0.9361560057.352.837C1
6382KLYS7.408732999-1.4048173469.7764.205C2
6383QGLN7.480314961-1.40258562513.4494.67C4
6384VVAL7.408732999-1.40481734612.655.542C3
6385VVAL21.08088762-0.97855869810.2126.06C3
6386SSER7.408732999-1.4048173469.9085.055C4
6387DASP22.72727273-0.9272291228.9215.901C3
6388IILE44.16607015-0.2588287817.7775.184C4
6389DASP51.75375805-0.022266397.6765.062C3
6390YTYR69.291338580.5245051754.6453.362C3
6391VVAL84.359341450.9942823773.7553.207C1
6392PPRO69.327129560.5256210353.0841.975C0
6393LLEU84.25196850.9909347963.3962.649C1
6394KLYS37.93843951-0.4529884793.1612.772C2
6395SSER40.51539012-0.3726465352.9781.858C2
6396AALA35.86256263-0.5177083792.9981.918C2
6397TTHR20.75876879-0.9886014412.5481.784E2
6398CCYS88.260558341.1159111532.4221.462E1
6399IILE81.245526130.8972025272.511.435E1
6400TTHR88.296349321.1170270142.7251.345C3
6401RARG31.60343593-0.6504957593.652.084G2
6402CCYS88.33214031.1181428744.4171.618G3
6403NASN88.367931281.1192587343.5381.682G2
6404LLEU36.43521832-0.4998546133.9412.218G1
6405GGLY88.296349321.1170270144.5872.278C0
6406GGLY83.858267720.9786603325.0412.399C0
6407AALA84.216177520.9898189354.6172.378C0
6408VVAL83.929849680.9808920533.3361.912C1
6409CCYS88.439513241.1214904553.5961.646C7
6410RARG22.51252684-0.9339242843.7372.242C5
6411HHIS7.193987115-1.4115125083.4221.654H4
6412HHIS88.439513241.1214904552.2881.505H1
6413AALA66.929133860.4508583931.6961.78H1
6414NASN12.34788833-1.250828622.7141.618H2
6415EGLU40.08589835-0.3860368593.5531.632H2
6416YTYR88.188976381.1136794333.3161.343H2
6417RARG42.37652112-0.3146217983.4652.182H2
6418LLEU2.14745884-1.5688488153.182.047H2
6419YTYR68.432355050.4977245272.7541.018H2
6420LLEU21.83249821-0.9551256312.8971.68H2
6421DASP7.337151038-1.4070490673.0361.512H2
6422AALA52.899069430.0134411412.1551.168H2
6423YTYR88.475304221.1226063151.9251.161H2
6424NASN88.403722261.1203745952.2991.593H2
6425MMET8.876163207-1.3590670722.2811.428H2
6426MMET12.27630637-1.253060341.381.191H2
6427IILE8.052970651-1.384731861.5451.286H2
6428SSER28.23908375-0.755386632.3851.317H2
6429AALA68.14602720.4887976442.3891.233H2
6430GGLY88.546886181.1248380362.2921.058H2
6431FPHE88.475304221.1226063151.6380.928C1
6432SSER7.480314961-1.4025856251.6020.998E0
6433LLEU24.87473157-0.8602775021.5191.185E1
6434WTRP84.359341450.9942823771.6021.014E2
6435VVAL58.410880460.1852836331.8891.141E4
6436YTYR35.75518969-0.521055962.2821.502E5
6437KLYS37.2226199-0.4753056862.3141.638T5
6438QGLN8.554044381-1.3691098152.6982.079T3
6439FPHE84.037222620.9842396342.2961.364T3
6440DASP69.07659270.5178100132.2691.577H2
6441TTHR31.6750179-0.6482640382.0561.731H2
6442YTYR84.896206161.0110202822.9791.997H1
6443NASN84.001431640.9831237733.2271.864H1
6444LLEU84.323550470.9931665162.5971.806H3
6445WTRP88.51109521.1237221762.911.743H2
6446NASN20.57981389-0.9941807423.3842.505H3
6447TTHR66.10594130.4251936052.6741.853C3
6448FPHE86.11309951.0489595332.7361.744C2
6449TTHR41.55332856-0.3402865853.5432.463T2
6450RARG8.482462419-1.3713415365.2153.95T0
6451LLEU40.47959914-0.3737623959.0514.344T0
6452QGLN55.762347890.10270996814.3095.66T0

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

4.            Rani R, Singh A, Pareek A, Tomar S. In silico Guided Drug Repurposing to Combat SARS-CoV-2 by Targeting Mpro, the key virus specific protease. 2020;