Envelope (E) Google Drive Data
Envelope (E)– E protein acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. This protein is also involved with induction of host apoptosis. Additionally, it activates the host NLRP3 inflammasome which causes IL-1beta overproduction.2 E protein mimics acetylated histones and binds at the same site on BRD-2. BRD-2 is involved with causing the hyper-immune response that SARS-CoV-2 patients often exhibit. Hydroxychloroquine (HCQ) may bind at the same place on BRD-2 where E protein binds, making it an effective BRD-2 inhibitor. Another drug, celecoxib (Celebrex), also binds in the same pocket of BRD-2. 36

Envelope (E) 94 Sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
1 | M | MET | 0.872340426 | 1.380597391 | 9.833 | 11.432 | C | 2 |
2 | Y | TYR | 0.382978723 | -0.726951724 | 7.831 | 8.672 | T | 2 |
3 | S | SER | 0.382978723 | -0.726951724 | 6.485 | 7.75 | T | 3 |
4 | F | PHE | 0.744680851 | 0.83080197 | 8.965 | 10.538 | T | 2 |
5 | V | VAL | 0.744680851 | 0.83080197 | 9.446 | 8.963 | T | 2 |
6 | S | SER | 0.393617021 | -0.681135439 | 7.574 | 6.144 | C | 1 |
7 | E | GLU | 0.64893617 | 0.418455404 | 7.15 | 5.735 | C | 0 |
8 | E | GLU | 0.382978723 | -0.726951724 | 5.856 | 5.815 | T | 0 |
9 | T | THR | 0.5 | -0.222972587 | 6.023 | 4.859 | T | 0 |
10 | G | GLY | 0.734042553 | 0.784985685 | 3.945 | 3.918 | T | 0 |
11 | T | THR | 0.436170213 | -0.497870298 | 3.999 | 4.397 | T | 0 |
12 | L | LEU | 0.382978723 | -0.726951724 | 7.124 | 5.163 | C | 0 |
13 | I | ILE | 0.787234043 | 1.01406711 | 5.202 | 4 | C | 0 |
14 | V | VAL | 0.776595745 | 0.968250825 | 6.481 | 3.612 | H | 2 |
15 | N | ASN | 0.85106383 | 1.288964821 | 8.767 | 4.027 | H | 3 |
16 | S | SER | 0.457446809 | -0.406237728 | 7.022 | 3.544 | H | 1 |
17 | V | VAL | 0.393617021 | -0.681135439 | 5.528 | 3.264 | H | 2 |
18 | L | LEU | 0.35106383 | -0.864400579 | 8.867 | 3.773 | H | 5 |
19 | L | LEU | 0.468085106 | -0.360421443 | 9.016 | 3.731 | H | 4 |
20 | F | PHE | 0.361702128 | -0.818584294 | 6.036 | 3.191 | H | 4 |
21 | L | LEU | 0.404255319 | -0.635319153 | 7.874 | 3.576 | H | 4 |
22 | A | ALA | 0.489361702 | -0.268788873 | 9.958 | 3.767 | H | 5 |
23 | F | PHE | 0.361702128 | -0.818584294 | 7.623 | 3.041 | H | 5 |
24 | V | VAL | 0.393617021 | -0.681135439 | 6.59 | 3.312 | H | 4 |
25 | V | VAL | 0.542553191 | -0.039707447 | 9.557 | 4.347 | H | 7 |
26 | F | PHE | 0.404255319 | -0.635319153 | 9.246 | 3.823 | H | 6 |
27 | L | LEU | 0.79787234 | 1.059883395 | 6.449 | 3.009 | H | 6 |
28 | L | LEU | 0.755319149 | 0.876618255 | 8.262 | 4.419 | H | 6 |
29 | V | VAL | 0.787234043 | 1.01406711 | 9.653 | 4.97 | H | 10 |
30 | T | THR | 0.329787234 | -0.956033149 | 7.225 | 3.463 | H | 7 |
31 | L | LEU | 0.436170213 | -0.497870298 | 5.97 | 3.619 | H | 8 |
32 | A | ALA | 0.968085106 | 1.792943957 | 9.13 | 5.084 | H | 8 |
33 | I | ILE | 0.468085106 | -0.360421443 | 8.749 | 5.027 | H | 7 |
34 | L | LEU | 0.989361702 | 1.884576527 | 5.744 | 3.211 | H | 9 |
35 | T | THR | 0.734042553 | 0.784985685 | 7.26 | 4.423 | H | 5 |
36 | A | ALA | 0.712765957 | 0.693353115 | 9.611 | 5.658 | H | 8 |
37 | L | LEU | 0.361702128 | -0.818584294 | 7.632 | 5.048 | H | 4 |
38 | R | ARG | 0.787234043 | 1.01406711 | 6.204 | 5.378 | C | 5 |
39 | L | LEU | 0.968085106 | 1.792943957 | 3.402 | 3.277 | H | 1 |
40 | C | CYS | 0.968085106 | 1.792943957 | 3.417 | 2.893 | H | 0 |
41 | A | ALA | 0.361702128 | -0.818584294 | 5.03 | 3.743 | H | 0 |
42 | Y | TYR | 0.35106383 | -0.864400579 | 4.214 | 3.426 | H | 0 |
43 | C | CYS | 0.85106383 | 1.288964821 | 3.084 | 2.822 | H | 0 |
44 | C | CYS | 0.627659574 | 0.326822834 | 3.045 | 3.262 | H | 0 |
45 | N | ASN | 0.361702128 | -0.818584294 | 5.687 | 4.345 | H | 0 |
46 | I | ILE | 0.382978723 | -0.726951724 | 6.658 | 4.374 | H | 0 |
47 | V | VAL | 0.478723404 | -0.314605158 | 5.294 | 3.69 | H | 0 |
48 | N | ASN | 0.925531915 | 1.609678817 | 5.053 | 4.481 | H | 1 |
49 | V | VAL | 0.457446809 | -0.406237728 | 8.054 | 5.945 | C | 1 |
50 | S | SER | 0.361702128 | -0.818584294 | 7.979 | 5.307 | C | 1 |
51 | L | LEU | 0.765957447 | 0.92243454 | 7.614 | 5.06 | C | 1 |
52 | V | VAL | 0.70212766 | 0.647536829 | 7.253 | 3.834 | C | 0 |
53 | K | LYS | 0.372340426 | -0.772768009 | 7.797 | 4.832 | G | 0 |
54 | P | PRO | 0.989361702 | 1.884576527 | 8.56 | 3.879 | G | 0 |
55 | S | SER | 0.159574468 | -1.689093711 | 8.731 | 3.444 | G | 0 |
56 | F | PHE | 0.117021277 | -1.872358851 | 9.606 | 3.845 | G | 0 |
57 | Y | TYR | 0.840425532 | 1.243148536 | 8.814 | 3.435 | G | 0 |
58 | V | VAL | 0.574468085 | 0.097741408 | 8.528 | 4.097 | H | 0 |
59 | Y | TYR | 0.978723404 | 1.838760242 | 9.291 | 4.535 | H | 0 |
60 | S | SER | 0.361702128 | -0.818584294 | 8.916 | 3.015 | H | 0 |
61 | R | ARG | 0.478723404 | -0.314605158 | 6.794 | 3.742 | H | 0 |
62 | V | VAL | 0.35106383 | -0.864400579 | 4.627 | 2.923 | H | 0 |
63 | K | LYS | 0.563829787 | 0.051925123 | 6.98 | 3.779 | H | 0 |
64 | N | ASN | 0.393617021 | -0.681135439 | 8.683 | 3.548 | H | 1 |
65 | L | LEU | 0.478723404 | -0.314605158 | 6.905 | 3.185 | H | 1 |
66 | N | ASN | 0.35106383 | -0.864400579 | 8.922 | 4.614 | H | 0 |
67 | S | SER | 0.372340426 | -0.772768009 | 11.888 | 5.696 | H | 1 |
68 | S | SER | 0.340425532 | -0.910216864 | 12.997 | 5.572 | C | 2 |
69 | R | ARG | 0.021276596 | -2.284705417 | 13.622 | 5.448 | C | 2 |
70 | V | VAL | 0.35106383 | -0.864400579 | 14.332 | 6.923 | C | 2 |
71 | P | PRO | 0.914893617 | 1.563862531 | 12.968 | 7.124 | C | 1 |
72 | D | ASP | 0.457446809 | -0.406237728 | 12.319 | 6.598 | T | 1 |
73 | L | LEU | 0.755319149 | 0.876618255 | 16.678 | 8.752 | T | 2 |
74 | L | LEU | 0.372340426 | -0.772768009 | 17.603 | 9.962 | T | 2 |
75 | V | VAL | 0.446808511 | -0.452054013 | 17.814 | 9.778 | T | 1 |
2. I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/
36. Khupse R, Dixit P. Potential Antiviral Mechanism of Hydroxychloroquine in COVID-19 and Further Extrapolation to Celecoxib (Celebrex) for Future Clinical Trials. [Internet]. Rochester, NY: Social Science Research Network; 2020 [cited 2020 Apr 10]. Available from: https://papers.ssrn.com/abstract=3570102