ACE2 and the Renin-Angiotensin System

Database of 235 Species of ACE2 interacting with Spike

Dynamics Cross Correlation Matrix for Spike interaction with the ACE2/SLC6A19 dimer

ACE2 Genomic Variants

InclusionProteinChromosomersIDAADamaging CallsHemizygote CountMax PopulationAfricanLatinoAshkenazi JewishEast AsianEuropean (Finnish)European (non-Finnish)OtherSouth Asian
Spike ContactACE2Xrs4646116K26R02820.0118767950.0009463220.0032487240.0118767956.73764E-050.0004832990.0058678860.0033783780.001312749
FunctionalACE2Xrs758142853V184A310.0005774090000.0005774090000
FunctionalACE2Xrs373025684S547C3.25190.00039001600.000144066005.37403E-050.0003900160.0003786440
GlycosylationACE2Xrs761944150N546D2.510.000367840.0003678400001.08281E-0500
FunctionalACE2Xrs776328956V447F320.00027122300000.0002712237.88226E-050.00020020
FunctionalACE2Xrs765152220D494V3.7530.000268835000005.37136E-0500.000268835
GlycosylationACE2Xrs143158922N103H0.500.0002106150.0002106150000000
Zinc BindingACE2Xrs142984500H378R4.560.000194968000000.00019496800
Spike ContactACE2Xrs143936283E329G010.000190476000006.50978E-050.0001904760
FunctionalACE2Xrs762890235P389H320.00018254200.0001825420002.4529E-0500
FunctionalACE2Xrs780574871E312K3.2510.0001565560.0001565560000000
FunctionalACE2Xrs139980377G726R3.2500.0001557750.0001557750000000
FunctionalACE2Xrs1316056737D427Y310.0001520910.0001520910000000
FunctionalACE2Xrs370187012R710H3.510.0001504320000.00015043206.09385E-0500
Spike ContactACE2Xrs1348114695E35K010.0001444360000.00014443601.22114E-0500
FunctionalACE2Xrs200745906P263S5.2500.000125798000000.00012579800
FunctionalACE2Xrs771621249N58K3.2500.00011305800000000.000113058
FunctionalACE2Xrs751484521P734L3.2510.00011203900000000.000112039
Acive SiteACE2Xrs1395782023E375D3.2510.00010958500.000109585000000
FunctionalACE2Xrs889263894K541I300.0001049480.0001049480000000
FunctionalACE2Xrs140016715R768W3.2508.54117E-058.12876E-05008.54117E-050000
FunctionalACE2Xrs901495523R710C5.507.60341E-050007.60341E-0504.909E-0500
Spike ContactACE2Xrs781255386T27A007.30327E-0507.30327E-05000000
FunctionalACE2Xrs766319182M270V426.44787E-05000006.44787E-0500
FunctionalACE2Xrs763994205N290H3.2515.82785E-05000001.24863E-0505.82785E-05
FunctionalACE2Xrs754511501G173S3.2525.24191E-05000003.66694E-0505.24191E-05
FunctionalACE2Xrs1360329820A242V3.2513.81956E-05000003.81956E-0500
FunctionalACE2Xrs776995986R708W3.2503.78927E-05000003.78927E-0500
FunctionalACE2Xrs756358940I291K5.2523.75756E-05000003.75756E-0500
FunctionalACE2Xrs750145841Y199C323.7508E-0503.7508E-050002.49769E-0500
FunctionalACE2Xrs148036434L595V3.2513.69631E-05000003.69631E-0500
FunctionalACE2Xrs1365935088N397D503.24623E-05000003.24623E-0500
FunctionalACE2Xrs760281053F504I3.2502.73613E-05000002.73613E-0500
Spike ContactACE2Xrs961360700D355N4.2502.59141E-05000002.59141E-0500
FunctionalACE2Xrs773936807Q300R302.57695E-05000002.57695E-0500
FunctionalACE2Xrs771769548Y252C3.502.50973E-05000002.50973E-0500
FunctionalACE2Xrs1248745003D292N4.2502.50812E-05000002.50812E-0500
FunctionalACE2Xrs1222417695N58H3.2512.4975E-05000002.4975E-0500
FunctionalACE2Xrs758568640M366T502.46299E-05000002.46299E-0500
FunctionalACE2Xrs755445931P696T3.2512.4542E-05000002.4542E-0500
Spike ContactACE2Xrs778030746I21V022.44636E-05000002.44636E-0500