Database of 235 Species of ACE2 interacting with Spike

ACE2 Genomic Variants

Inclusion	Protein	Chromosome	rsID	AA	Damaging Calls	Hemizygote Count	Max Population	African	Latino	Ashkenazi Jewish	East Asian	European (Finnish)	European (non-Finnish)	Other	South Asian
Spike Contact	ACE2	X	rs4646116	K26R	0	282	0.011876795	0.000946322	0.003248724	0.011876795	6.73764E-05	0.000483299	0.005867886	0.003378378	0.001312749
Functional	ACE2	X	rs758142853	V184A	3	1	0.000577409	0	0	0	0.000577409	0	0	0	0
Functional	ACE2	X	rs373025684	S547C	3.25	19	0.000390016	0	0.000144066	0	0	5.37403E-05	0.000390016	0.000378644	0
Glycosylation	ACE2	X	rs761944150	N546D	2.5	1	0.00036784	0.00036784	0	0	0	0	1.08281E-05	0	0
Functional	ACE2	X	rs776328956	V447F	3	2	0.000271223	0	0	0	0	0.000271223	7.88226E-05	0.0002002	0
Functional	ACE2	X	rs765152220	D494V	3.75	3	0.000268835	0	0	0	0	0	5.37136E-05	0	0.000268835
Glycosylation	ACE2	X	rs143158922	N103H	0.5	0	0.000210615	0.000210615	0	0	0	0	0	0	0
Zinc Binding	ACE2	X	rs142984500	H378R	4.5	6	0.000194968	0	0	0	0	0	0.000194968	0	0
Spike Contact	ACE2	X	rs143936283	E329G	0	1	0.000190476	0	0	0	0	0	6.50978E-05	0.000190476	0
Functional	ACE2	X	rs762890235	P389H	3	2	0.000182542	0	0.000182542	0	0	0	2.4529E-05	0	0
Functional	ACE2	X	rs780574871	E312K	3.25	1	0.000156556	0.000156556	0	0	0	0	0	0	0
Functional	ACE2	X	rs139980377	G726R	3.25	0	0.000155775	0.000155775	0	0	0	0	0	0	0
Functional	ACE2	X	rs1316056737	D427Y	3	1	0.000152091	0.000152091	0	0	0	0	0	0	0
Functional	ACE2	X	rs370187012	R710H	3.5	1	0.000150432	0	0	0	0.000150432	0	6.09385E-05	0	0
Spike Contact	ACE2	X	rs1348114695	E35K	0	1	0.000144436	0	0	0	0.000144436	0	1.22114E-05	0	0
Functional	ACE2	X	rs200745906	P263S	5.25	0	0.000125798	0	0	0	0	0	0.000125798	0	0
Functional	ACE2	X	rs771621249	N58K	3.25	0	0.000113058	0	0	0	0	0	0	0	0.000113058
Functional	ACE2	X	rs751484521	P734L	3.25	1	0.000112039	0	0	0	0	0	0	0	0.000112039
Acive Site	ACE2	X	rs1395782023	E375D	3.25	1	0.000109585	0	0.000109585	0	0	0	0	0	0
Functional	ACE2	X	rs889263894	K541I	3	0	0.000104948	0.000104948	0	0	0	0	0	0	0
Functional	ACE2	X	rs140016715	R768W	3.25	0	8.54117E-05	8.12876E-05	0	0	8.54117E-05	0	0	0	0
Functional	ACE2	X	rs901495523	R710C	5.5	0	7.60341E-05	0	0	0	7.60341E-05	0	4.909E-05	0	0
Spike Contact	ACE2	X	rs781255386	T27A	0	0	7.30327E-05	0	7.30327E-05	0	0	0	0	0	0
Functional	ACE2	X	rs766319182	M270V	4	2	6.44787E-05	0	0	0	0	0	6.44787E-05	0	0
Functional	ACE2	X	rs763994205	N290H	3.25	1	5.82785E-05	0	0	0	0	0	1.24863E-05	0	5.82785E-05
Functional	ACE2	X	rs754511501	G173S	3.25	2	5.24191E-05	0	0	0	0	0	3.66694E-05	0	5.24191E-05
Functional	ACE2	X	rs1360329820	A242V	3.25	1	3.81956E-05	0	0	0	0	0	3.81956E-05	0	0
Functional	ACE2	X	rs776995986	R708W	3.25	0	3.78927E-05	0	0	0	0	0	3.78927E-05	0	0
Functional	ACE2	X	rs756358940	I291K	5.25	2	3.75756E-05	0	0	0	0	0	3.75756E-05	0	0
Functional	ACE2	X	rs750145841	Y199C	3	2	3.7508E-05	0	3.7508E-05	0	0	0	2.49769E-05	0	0
Functional	ACE2	X	rs148036434	L595V	3.25	1	3.69631E-05	0	0	0	0	0	3.69631E-05	0	0
Functional	ACE2	X	rs1365935088	N397D	5	0	3.24623E-05	0	0	0	0	0	3.24623E-05	0	0
Functional	ACE2	X	rs760281053	F504I	3.25	0	2.73613E-05	0	0	0	0	0	2.73613E-05	0	0
Spike Contact	ACE2	X	rs961360700	D355N	4.25	0	2.59141E-05	0	0	0	0	0	2.59141E-05	0	0
Functional	ACE2	X	rs773936807	Q300R	3	0	2.57695E-05	0	0	0	0	0	2.57695E-05	0	0
Functional	ACE2	X	rs771769548	Y252C	3.5	0	2.50973E-05	0	0	0	0	0	2.50973E-05	0	0
Functional	ACE2	X	rs1248745003	D292N	4.25	0	2.50812E-05	0	0	0	0	0	2.50812E-05	0	0
Functional	ACE2	X	rs1222417695	N58H	3.25	1	2.4975E-05	0	0	0	0	0	2.4975E-05	0	0
Functional	ACE2	X	rs758568640	M366T	5	0	2.46299E-05	0	0	0	0	0	2.46299E-05	0	0
Functional	ACE2	X	rs755445931	P696T	3.25	1	2.4542E-05	0	0	0	0	0	2.4542E-05	0	0
Spike Contact	ACE2	X	rs778030746	I21V	0	2	2.44636E-05	0	0	0	0	0	2.44636E-05	0	0