ORF7a Google Drive Data

ORF7a– a non-structural protein which is not required for viral replication in cell culture. It is known to suppress host tetherin activity and cause virus-induced apoptosis.^2,8

ORF7a 42 Sequences

Amino Acid	AA	AA	Conservation	Conservation Z-score	RMSD_CA	RMSF[A]	Secondary Structure	DCCM >0.9
1	M	MET	100	0.901963415	16.323	15.21	C	3
2	K	LYS	88.0952381	0.432756307	14.444	13.961	C	3
3	I	ILE	85.71428571	0.338914886	12.184	11.752	C	4
4	I	ILE	83.33333333	0.245073464	10.281	10.018	C	4
5	L	LEU	85.71428571	0.338914886	9.06	8.37	C	2
6	F	PHE	80.95238095	0.151232043	8.669	7.529	C	1
7	L	LEU	92.85714286	0.62043915	8.114	6.594	C	3
8	A	ALA	7.142857143	-2.757852023	9.925	5.834	H	4
9	L	LEU	90.47619048	0.526597729	11.28	5.813	H	2
10	I	ILE	76.19047619	-0.0364508	10.572	5.845	H	3
11	T	THR	9.523809524	-2.664010601	7.345	5.899	H	6
12	L	LEU	64.28571429	-0.505657907	8.752	5.579	H	4
13	A	ALA	64.28571429	-0.505657907	9.274	5.121	H	4
14	T	THR	38.0952381	-1.537913544	6.948	6.196	C	5
15	C	CYS	73.80952381	-0.130292222	8.662	6.013	E	9
16	E	GLU	92.85714286	0.62043915	8.273	5.19	E	9
17	L	LEU	88.0952381	0.432756307	7.814	5.309	E	10
18	Y	TYR	88.0952381	0.432756307	7.309	4.867	E	7
19	H	HIS	97.61904762	0.808121993	7.372	4.554	E	6
20	Y	TYR	100	0.901963415	7.165	4.913	E	7
21	Q	GLN	85.71428571	0.338914886	6.88	4.403	E	5
22	E	GLU	88.0952381	0.432756307	7.287	5.174	E	8
23	C	CYS	100	0.901963415	7.556	4.415	E	11
24	V	VAL	83.33333333	0.245073464	7.643	5.162	T	12
25	R	ARG	88.0952381	0.432756307	6.855	4.411	T	11
26	G	GLY	100	0.901963415	6.711	4.108	T	7
27	T	THR	95.23809524	0.714280572	7.63	4.714	E	7
28	T	THR	90.47619048	0.526597729	7.915	4.334	E	10
29	V	VAL	88.0952381	0.432756307	8.197	4.027	E	10
30	L	LEU	88.0952381	0.432756307	8.805	4.639	E	8
31	L	LEU	90.47619048	0.526597729	8.514	3.805	E	8
32	K	LYS	69.04761905	-0.317975064	9.45	4.978	C	8
33	E	GLU	88.0952381	0.432756307	9.586	4.082	C	7
34	P	PRO	100	0.901963415	9.942	4.475	C	5
35	C	CYS	100	0.901963415	10.8	4.806	C	6
36	S	SER	11.9047619	-2.57016918	11.184	5.142	C	6
37	S	SER	83.33333333	0.245073464	11.049	5.012	C	7
38	G	GLY	78.57142857	0.057390621	10.658	4.405	C	10
39	T	THR	92.85714286	0.62043915	11.023	4.406	E	8
40	Y	TYR	88.0952381	0.432756307	9.359	4.368	E	6
41	E	GLU	97.61904762	0.808121993	8.313	3.93	E	4
42	G	GLY	88.0952381	0.432756307	7.278	3.513	C	3
43	N	ASN	88.0952381	0.432756307	5.85	4.043	C	2
44	S	SER	97.61904762	0.808121993	6.383	3.463	C	2
45	P	PRO	97.61904762	0.808121993	8.295	3.873	C	2
46	F	PHE	83.33333333	0.245073464	9.322	3.931	C	3
47	H	HIS	85.71428571	0.338914886	9.014	4.101	C	3
48	P	PRO	88.0952381	0.432756307	9.952	4.044	C	6
49	L	LEU	85.71428571	0.338914886	10.656	4.437	C	8
50	A	ALA	90.47619048	0.526597729	11.798	5.107	T	7
51	D	ASP	85.71428571	0.338914886	11.844	5.445	T	8
52	N	ASN	88.0952381	0.432756307	11.254	4.719	T	8
53	K	LYS	85.71428571	0.338914886	10.397	4.929	T	10
54	F	PHE	85.71428571	0.338914886	9.204	3.473	E	11
55	A	ALA	95.23809524	0.714280572	8.39	3.64	E	10
56	L	LEU	80.95238095	0.151232043	7.281	3.052	E	5
57	T	THR	83.33333333	0.245073464	6.644	3.363	E	7
58	C	CYS	97.61904762	0.808121993	6.646	3.562	C	10
59	F	PHE	9.523809524	-2.664010601	5.699	3.531	C	5
60	S	SER	83.33333333	0.245073464	5.289	3.152	C	5
61	T	THR	88.0952381	0.432756307	5.433	2.693	E	2
62	Q	GLN	9.523809524	-2.664010601	6.216	3.197	E	3
63	F	PHE	85.71428571	0.338914886	7.862	2.864	E	4
64	A	ALA	80.95238095	0.151232043	8.157	3.395	E	7
65	F	PHE	88.0952381	0.432756307	9.358	3.772	E	14
66	A	ALA	80.95238095	0.151232043	10.581	4.436	E	14
67	C	CYS	85.71428571	0.338914886	10.758	4.993	E	14
68	P	PRO	9.523809524	-2.664010601	11.305	5.561	T	10
69	D	ASP	85.71428571	0.338914886	10.291	6.15	T	9
70	G	GLY	83.33333333	0.245073464	10.229	5.803	E	9
71	V	VAL	9.523809524	-2.664010601	9.375	5.555	E	12
72	K	LYS	7.142857143	-2.757852023	9.206	4.677	E	13
73	H	HIS	85.71428571	0.338914886	8.625	4.467	E	13
74	V	VAL	7.142857143	-2.757852023	7.945	3.926	E	11
75	Y	TYR	85.71428571	0.338914886	7.566	3.663	E	7
76	Q	GLN	88.0952381	0.432756307	6.458	3.726	E	7
77	L	LEU	85.71428571	0.338914886	6.395	3.367	E	8
78	R	ARG	85.71428571	0.338914886	6.457	4.555	E	9
79	A	ALA	85.71428571	0.338914886	6.429	3.866	E	11
80	R	ARG	97.61904762	0.808121993	6.9	5.062	E	8
81	S	SER	88.0952381	0.432756307	7.387	5.415	C	7
82	V	VAL	88.0952381	0.432756307	7.84	5.811	C	5
83	S	SER	90.47619048	0.526597729	7.684	6.084	C	3
84	P	PRO	83.33333333	0.245073464	8.266	6.807	C	2
85	K	LYS	80.95238095	0.151232043	7.886	6.619	C	2
86	L	LEU	85.71428571	0.338914886	7.094	5.525	C	2
87	F	PHE	88.0952381	0.432756307	9.342	6.965	C	2
88	I	ILE	61.9047619	-0.599499329	10.405	6.74	C	4
89	R	ARG	80.95238095	0.151232043	10.313	8.165	T	5
90	Q	GLN	80.95238095	0.151232043	9.839	6.684	T	5
91	E	GLU	80.95238095	0.151232043	14.071	9.347	T	5
92	E	GLU	64.28571429	-0.505657907	14.387	8.774	T	8
93	V	VAL	80.95238095	0.151232043	12.024	6.523	T	9
94	Q	GLN	80.95238095	0.151232043	13.279	8.306	T	7
95	E	GLU	80.95238095	0.151232043	17.936	10.042	T	6
96	L	LEU	85.71428571	0.338914886	19.706	9.023	T	6
97	Y	TYR	83.33333333	0.245073464	16.748	8.234	C	7
98	S	SER	80.95238095	0.151232043	16.349	9.008	C	7
99	P	PRO	85.71428571	0.338914886	18.259	9.197	C	4
100	I	ILE	4.761904762	-2.851693444	16.779	7.911	H	5
101	F	PHE	80.95238095	0.151232043	16.883	7.874	H	5
102	L	LEU	100	0.901963415	17.18	8.428	H	5
103	I	ILE	95.23809524	0.714280572	17.405	8.176	H	4
104	V	VAL	88.0952381	0.432756307	17.908	7.438	H	5
105	A	ALA	78.57142857	0.057390621	17.531	7.259	H	5
106	A	ALA	78.57142857	0.057390621	17.645	7.561	H	5
107	I	ILE	11.9047619	-2.57016918	19.174	8.57	H	7
108	V	VAL	80.95238095	0.151232043	19.901	8.663	H	8
109	F	PHE	85.71428571	0.338914886	19.49	8.2	H	8
110	I	ILE	64.28571429	-0.505657907	20.453	9.185	H	7
111	T	THR	7.142857143	-2.757852023	24.021	10.498	H	9
112	L	LEU	92.85714286	0.62043915	23.395	10.711	H	10
113	C	CYS	85.71428571	0.338914886	21.98	10.71	H	9
114	F	PHE	80.95238095	0.151232043	24.668	12.831	H	6
115	T	THR	80.95238095	0.151232043	27.956	13.099	C	6
116	L	LEU	9.523809524	-2.664010601	29.322	15.462	T	8
117	K	LYS	83.33333333	0.245073464	29.991	13.626	T	6
118	R	ARG	92.85714286	0.62043915	32.127	13.635	T	5
119	K	LYS	78.57142857	0.057390621	35.462	17.717	T	5
120	T	THR	66.66666667	-0.411816486	37.771	16.452	C	4
121	E	GLU	80.95238095	0.151232043	41.12	17.04	C	2

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

8.            Gordon DE, Jang GM, Bouhaddou M, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv 2020;2020.03.22.002386.