ORF7a Google Drive Data

Gray amino acids fall below the average conservation (value <0) for each protein, yellow = 0-0.5, light orange = 0.5-1, orange = 1-1.5, dark orange = 1.5-2, red = >2

ORF7a– a non-structural protein which is not required for viral replication in cell culture. It is known to suppress host tetherin activity and cause virus-induced apoptosis.2,8

ORF7a 42 Sequences

Amino AcidAAAAConservationConservation Z-scoreRMSD_CARMSF[A]Secondary StructureDCCM >0.9
1MMET1000.90196341516.32315.21C3
2KLYS88.09523810.43275630714.44413.961C3
3IILE85.714285710.33891488612.18411.752C4
4IILE83.333333330.24507346410.28110.018C4
5LLEU85.714285710.3389148869.068.37C2
6FPHE80.952380950.1512320438.6697.529C1
7LLEU92.857142860.620439158.1146.594C3
8AALA7.142857143-2.7578520239.9255.834H4
9LLEU90.476190480.52659772911.285.813H2
10IILE76.19047619-0.036450810.5725.845H3
11TTHR9.523809524-2.6640106017.3455.899H6
12LLEU64.28571429-0.5056579078.7525.579H4
13AALA64.28571429-0.5056579079.2745.121H4
14TTHR38.0952381-1.5379135446.9486.196C5
15CCYS73.80952381-0.1302922228.6626.013E9
16EGLU92.857142860.620439158.2735.19E9
17LLEU88.09523810.4327563077.8145.309E10
18YTYR88.09523810.4327563077.3094.867E7
19HHIS97.619047620.8081219937.3724.554E6
20YTYR1000.9019634157.1654.913E7
21QGLN85.714285710.3389148866.884.403E5
22EGLU88.09523810.4327563077.2875.174E8
23CCYS1000.9019634157.5564.415E11
24VVAL83.333333330.2450734647.6435.162T12
25RARG88.09523810.4327563076.8554.411T11
26GGLY1000.9019634156.7114.108T7
27TTHR95.238095240.7142805727.634.714E7
28TTHR90.476190480.5265977297.9154.334E10
29VVAL88.09523810.4327563078.1974.027E10
30LLEU88.09523810.4327563078.8054.639E8
31LLEU90.476190480.5265977298.5143.805E8
32KLYS69.04761905-0.3179750649.454.978C8
33EGLU88.09523810.4327563079.5864.082C7
34PPRO1000.9019634159.9424.475C5
35CCYS1000.90196341510.84.806C6
36SSER11.9047619-2.5701691811.1845.142C6
37SSER83.333333330.24507346411.0495.012C7
38GGLY78.571428570.05739062110.6584.405C10
39TTHR92.857142860.6204391511.0234.406E8
40YTYR88.09523810.4327563079.3594.368E6
41EGLU97.619047620.8081219938.3133.93E4
42GGLY88.09523810.4327563077.2783.513C3
43NASN88.09523810.4327563075.854.043C2
44SSER97.619047620.8081219936.3833.463C2
45PPRO97.619047620.8081219938.2953.873C2
46FPHE83.333333330.2450734649.3223.931C3
47HHIS85.714285710.3389148869.0144.101C3
48PPRO88.09523810.4327563079.9524.044C6
49LLEU85.714285710.33891488610.6564.437C8
50AALA90.476190480.52659772911.7985.107T7
51DASP85.714285710.33891488611.8445.445T8
52NASN88.09523810.43275630711.2544.719T8
53KLYS85.714285710.33891488610.3974.929T10
54FPHE85.714285710.3389148869.2043.473E11
55AALA95.238095240.7142805728.393.64E10
56LLEU80.952380950.1512320437.2813.052E5
57TTHR83.333333330.2450734646.6443.363E7
58CCYS97.619047620.8081219936.6463.562C10
59FPHE9.523809524-2.6640106015.6993.531C5
60SSER83.333333330.2450734645.2893.152C5
61TTHR88.09523810.4327563075.4332.693E2
62QGLN9.523809524-2.6640106016.2163.197E3
63FPHE85.714285710.3389148867.8622.864E4
64AALA80.952380950.1512320438.1573.395E7
65FPHE88.09523810.4327563079.3583.772E14
66AALA80.952380950.15123204310.5814.436E14
67CCYS85.714285710.33891488610.7584.993E14
68PPRO9.523809524-2.66401060111.3055.561T10
69DASP85.714285710.33891488610.2916.15T9
70GGLY83.333333330.24507346410.2295.803E9
71VVAL9.523809524-2.6640106019.3755.555E12
72KLYS7.142857143-2.7578520239.2064.677E13
73HHIS85.714285710.3389148868.6254.467E13
74VVAL7.142857143-2.7578520237.9453.926E11
75YTYR85.714285710.3389148867.5663.663E7
76QGLN88.09523810.4327563076.4583.726E7
77LLEU85.714285710.3389148866.3953.367E8
78RARG85.714285710.3389148866.4574.555E9
79AALA85.714285710.3389148866.4293.866E11
80RARG97.619047620.8081219936.95.062E8
81SSER88.09523810.4327563077.3875.415C7
82VVAL88.09523810.4327563077.845.811C5
83SSER90.476190480.5265977297.6846.084C3
84PPRO83.333333330.2450734648.2666.807C2
85KLYS80.952380950.1512320437.8866.619C2
86LLEU85.714285710.3389148867.0945.525C2
87FPHE88.09523810.4327563079.3426.965C2
88IILE61.9047619-0.59949932910.4056.74C4
89RARG80.952380950.15123204310.3138.165T5
90QGLN80.952380950.1512320439.8396.684T5
91EGLU80.952380950.15123204314.0719.347T5
92EGLU64.28571429-0.50565790714.3878.774T8
93VVAL80.952380950.15123204312.0246.523T9
94QGLN80.952380950.15123204313.2798.306T7
95EGLU80.952380950.15123204317.93610.042T6
96LLEU85.714285710.33891488619.7069.023T6
97YTYR83.333333330.24507346416.7488.234C7
98SSER80.952380950.15123204316.3499.008C7
99PPRO85.714285710.33891488618.2599.197C4
100IILE4.761904762-2.85169344416.7797.911H5
101FPHE80.952380950.15123204316.8837.874H5
102LLEU1000.90196341517.188.428H5
103IILE95.238095240.71428057217.4058.176H4
104VVAL88.09523810.43275630717.9087.438H5
105AALA78.571428570.05739062117.5317.259H5
106AALA78.571428570.05739062117.6457.561H5
107IILE11.9047619-2.5701691819.1748.57H7
108VVAL80.952380950.15123204319.9018.663H8
109FPHE85.714285710.33891488619.498.2H8
110IILE64.28571429-0.50565790720.4539.185H7
111TTHR7.142857143-2.75785202324.02110.498H9
112LLEU92.857142860.6204391523.39510.711H10
113CCYS85.714285710.33891488621.9810.71H9
114FPHE80.952380950.15123204324.66812.831H6
115TTHR80.952380950.15123204327.95613.099C6
116LLEU9.523809524-2.66401060129.32215.462T8
117KLYS83.333333330.24507346429.99113.626T6
118RARG92.857142860.6204391532.12713.635T5
119KLYS78.571428570.05739062135.46217.717T5
120TTHR66.66666667-0.41181648637.77116.452C4
121EGLU80.952380950.15123204341.1217.04C2

2.            I-TASSER server for protein structure and function prediction [Internet]. [cited 2020 Apr 12];Available from: https://zhanglab.ccmb.med.umich.edu/I-TASSER/

8.            Gordon DE, Jang GM, Bouhaddou M, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv 2020;2020.03.22.002386.