3C-like proteinase Google Drive Data
Cysteine-like protease (3CLpro) (Mpro) (nsp5)– the 3D structure of 3CLpro of SARS-CoV-2 is very similar to SARS-CoV with a sequence identity of >96%.7 3CLpro is responsible for all cleavage events not mediated by PLpro, it cleaves nsp4-16. It recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. The protease is also able to bind an ADP-ribose-1”-phosphate (ADRP).2 3CLpro also interferes with localization of some proteins. Wild-type 3CLpro inhibits histone deacetylase 2 (HDAC2) transport into the nucleus, potentially impacting mediation of inflammation and interferon response. 3CLpro (C145A) interferes with tRNA methyltransferase 1 (TRMT1). TRMT1 is cleaved by 3CLpro, removing its zinc finger and nuclear localization signal and likely resulting in an exclusively mitochondrial localization. TRMT1 is responsible for synthesis of the dimethylguanosine (m2,2G) base modification on both nuclear and mitochondrial tRNAs40.8 3CLpro is a promising target for anti-coronaviral drugs. One study found that Cobicistat and Amprenavir bind to the protease effectively. Amprenavir’s prodrug version is called Fosamprenavir, and is currently used in treating HIV. The study recommended Fosamprenavir be considered as a potential treatment for SARS-CoV-2.9 Another study identified compound 621 from Asinex Focused Covalent Library as well as Paritaprevir and Simeprevir from FDA-approved protease inhibitors as potential inhibitors of 3CLpro. 10 Antivirals ledipasvir and velpatasvir are attractive therapeutics as well. Based on an in silico study, 2-deoxy-D-glucose can inactivate 3CLpro and nsp15 endoribonuclease.11

3C-like proteinase 3,397 Sequences
Amino Acid | AA | AA | Conservation | Conservation Z-score | RMSD_CA | RMSF[A] | Secondary Structure | DCCM >0.9 |
3264 | S | SER | 56.55375552 | 0.192178888 | 2.749 | 1.574 | C | 0 |
3265 | G | GLY | 99.73490427 | 1.433066696 | 2.351 | 0.967 | C | 0 |
3266 | F | PHE | 25.09572901 | -0.711823963 | 2.078 | 0.96 | C | 0 |
3267 | R | ARG | 37.58468336 | -0.352931445 | 2.866 | 0.844 | C | 1 |
3268 | K | LYS | 95.40500736 | 1.308639338 | 3.275 | 1.06 | C | 1 |
3269 | M | MET | 78.910162 | 0.834630352 | 3.766 | 1.325 | C | 0 |
3270 | A | ALA | 44.00589102 | -0.168406519 | 2.337 | 0.899 | C | 0 |
3271 | F | PHE | 11.51693667 | -1.102034931 | 1.044 | 1.732 | C | 0 |
3272 | P | PRO | 99.79381443 | 1.434759586 | 1.571 | 1.329 | C | 0 |
3273 | S | SER | 85.65537555 | 1.028466169 | 1.719 | 1.449 | C | 0 |
3274 | G | GLY | 70.27982327 | 0.58662208 | 2.586 | 1.636 | C | 0 |
3275 | K | LYS | 23.00441826 | -0.77192153 | 2.697 | 2.386 | C | 0 |
3276 | V | VAL | 97.64359352 | 1.372969129 | 2.407 | 1.662 | C | 0 |
3277 | E | GLU | 99.82326951 | 1.43560603 | 2.23 | 1.229 | C | 0 |
3278 | G | GLY | 10.0736377 | -1.143510717 | 2.218 | 0.943 | C | 0 |
3279 | C | CYS | 99.73490427 | 1.433066696 | 1.932 | 0.923 | E | 0 |
3280 | M | MET | 35.52282769 | -0.412182568 | 1.641 | 0.867 | E | 0 |
3281 | V | VAL | 99.76435935 | 1.433913141 | 1.403 | 0.983 | E | 0 |
3282 | Q | GLN | 32.57731959 | -0.49682703 | 1.446 | 1.273 | E | 1 |
3283 | V | VAL | 99.73490427 | 1.433066696 | 1.159 | 1.081 | E | 2 |
3284 | T | THR | 47.27540501 | -0.074451166 | 1.336 | 1.134 | E | 2 |
3285 | C | CYS | 32.69513991 | -0.493441252 | 1.702 | 1.215 | E | 1 |
3286 | G | GLY | 80.11782032 | 0.869334582 | 4.04 | 1.525 | T | 0 |
3287 | T | THR | 9.484536082 | -1.16043961 | 3.529 | 1.953 | T | 0 |
3288 | T | THR | 17.5257732 | -0.929360229 | 1.749 | 1.483 | E | 1 |
3289 | T | THR | 49.07216495 | -0.022818045 | 1.474 | 1.277 | E | 2 |
3290 | L | LEU | 99.82326951 | 1.43560603 | 1.25 | 1.523 | E | 1 |
3291 | N | ASN | 99.82326951 | 1.43560603 | 1.142 | 0.776 | E | 0 |
3292 | G | GLY | 99.73490427 | 1.433066696 | 1.106 | 0.723 | E | 0 |
3293 | L | LEU | 90.57437408 | 1.16982242 | 1.257 | 0.898 | E | 1 |
3294 | W | TRP | 99.85272459 | 1.436452475 | 1.171 | 0.833 | E | 1 |
3295 | L | LEU | 98.46833579 | 1.396669578 | 1.63 | 1.009 | E | 0 |
3296 | D | ASP | 48.07069219 | -0.051597162 | 1.422 | 1.277 | T | 0 |
3297 | D | ASP | 71.45802651 | 0.620479864 | 1.196 | 1.101 | T | 0 |
3298 | V | VAL | 6.715758468 | -1.240005404 | 1.135 | 1.213 | E | 0 |
3299 | V | VAL | 84.62444772 | 0.998840608 | 0.77 | 0.958 | E | 0 |
3300 | Y | TYR | 48.12960236 | -0.049904272 | 0.812 | 0.876 | E | 0 |
3301 | C | CYS | 99.55817378 | 1.427988029 | 0.937 | 1.007 | E | 0 |
3302 | P | PRO | 99.85272459 | 1.436452475 | 0.856 | 0.983 | C | 0 |
3303 | R | ARG | 99.85272459 | 1.436452475 | 1.333 | 1.417 | G | 0 |
3304 | H | HIS | 99.82326951 | 1.43560603 | 1.865 | 2.13 | G | 1 |
3305 | V | VAL | 98.88070692 | 1.408519802 | 1.316 | 1.482 | G | 1 |
3306 | I | ILE | 58.05596465 | 0.235347564 | 1.598 | 1.642 | G | 0 |
3307 | C | CYS | 46.92194404 | -0.084608502 | 1.814 | 1.83 | C | 1 |
3308 | T | THR | 9.337260677 | -1.164671833 | 2.584 | 2.099 | T | 2 |
3309 | S | SER | 25.56701031 | -0.698280849 | 2.626 | 2.262 | T | 2 |
3310 | E | GLU | 9.366715758 | -1.163825388 | 2.285 | 2.384 | T | 2 |
3311 | D | ASP | 21.79675994 | -0.80662576 | 1.847 | 1.826 | T | 1 |
3312 | M | MET | 23.03387334 | -0.771075086 | 1.987 | 2.46 | C | 0 |
3313 | L | LEU | 12.81296024 | -1.064791368 | 1.917 | 2.53 | C | 0 |
3314 | N | ASN | 20.14727541 | -0.854026658 | 2.567 | 2.896 | C | 0 |
3315 | P | PRO | 46.9808542 | -0.082915612 | 2.857 | 3.233 | C | 0 |
3316 | N | ASN | 32.57731959 | -0.49682703 | 3.468 | 2.939 | H | 0 |
3317 | Y | TYR | 80.20618557 | 0.871873915 | 2.964 | 2.66 | H | 1 |
3318 | E | GLU | 14.93372607 | -1.003847355 | 3.195 | 3.158 | H | 1 |
3319 | D | ASP | 25.03681885 | -0.713516852 | 2.545 | 2.324 | H | 0 |
3320 | L | LEU | 46.95139912 | -0.083762057 | 2.446 | 2.153 | H | 0 |
3321 | L | LEU | 82.65095729 | 0.942128819 | 2.117 | 2.266 | H | 0 |
3322 | I | ILE | 31.7820324 | -0.519681035 | 2.167 | 2.195 | H | 0 |
3323 | R | ARG | 23.62297496 | -0.754146194 | 2.213 | 3.083 | H | 1 |
3324 | K | LYS | 10.16200295 | -1.140971383 | 2.223 | 1.802 | C | 1 |
3325 | S | SER | 9.484536082 | -1.16043961 | 2.164 | 1.671 | T | 0 |
3326 | N | ASN | 49.01325479 | -0.024510934 | 1.558 | 1.34 | T | 1 |
3327 | H | HIS | 78.55670103 | 0.824473017 | 1.698 | 2.007 | T | 2 |
3328 | N | ASN | 34.87481591 | -0.43080435 | 2.048 | 1.449 | T | 1 |
3329 | F | PHE | 99.5287187 | 1.427141584 | 1.333 | 1.329 | C | 0 |
3330 | L | LEU | 9.278350515 | -1.166364722 | 1.233 | 1.576 | E | 0 |
3331 | V | VAL | 69.33726068 | 0.559535852 | 1.119 | 1.235 | E | 0 |
3332 | Q | GLN | 32.60677467 | -0.495980585 | 1.799 | 1.377 | E | 0 |
3333 | A | ALA | 9.690721649 | -1.154514497 | 1.629 | 1.235 | E | 0 |
3334 | G | GLY | 41.14874816 | -0.250511647 | 2.361 | 1.77 | T | 0 |
3335 | N | ASN | 50.78055965 | 0.026275743 | 3.57 | 3.205 | T | 0 |
3336 | V | VAL | 50.78055965 | 0.026275743 | 2.146 | 1.936 | E | 0 |
3337 | Q | GLN | 13.04860088 | -1.058019811 | 1.997 | 2.172 | E | 0 |
3338 | L | LEU | 99.23416789 | 1.418677138 | 1.209 | 1.23 | E | 0 |
3339 | R | ARG | 33.28424153 | -0.476512359 | 1.165 | 2.001 | E | 1 |
3340 | V | VAL | 99.46980854 | 1.425448695 | 1.11 | 1.298 | E | 2 |
3341 | I | ILE | 11.75257732 | -1.095263374 | 1.326 | 1.305 | E | 2 |
3342 | G | GLY | 57.40795287 | 0.216725782 | 1.35 | 1.163 | E | 3 |
3343 | H | HIS | 33.28424153 | -0.476512359 | 1.276 | 1.507 | E | 2 |
3344 | S | SER | 11.95876289 | -1.089338262 | 1.295 | 1.479 | E | 2 |
3345 | M | MET | 78.46833579 | 0.821933683 | 1.424 | 1.835 | E | 1 |
3346 | Q | GLN | 40.97201767 | -0.255590314 | 2.126 | 1.969 | E | 1 |
3347 | N | ASN | 9.278350515 | -1.166364722 | 1.885 | 1.359 | T | 2 |
3348 | C | CYS | 22.06185567 | -0.799007758 | 1.227 | 1.109 | T | 2 |
3349 | V | VAL | 20.4712813 | -0.844715768 | 1.019 | 1.06 | E | 1 |
3350 | L | LEU | 99.67599411 | 1.431373807 | 1.002 | 1.644 | E | 1 |
3351 | K | LYS | 29.27835052 | -0.591628827 | 1.034 | 1.531 | E | 1 |
3352 | L | LEU | 71.84094256 | 0.631483644 | 1.034 | 1.209 | E | 1 |
3353 | K | LYS | 41.00147275 | -0.25474387 | 1.098 | 1.67 | E | 3 |
3354 | V | VAL | 84.47717231 | 0.994608385 | 0.929 | 1.102 | E | 2 |
3355 | D | ASP | 33.10751105 | -0.481591027 | 1.151 | 1.402 | C | 1 |
3356 | T | THR | 13.25478645 | -1.052094699 | 1.179 | 1.461 | C | 0 |
3357 | A | ALA | 38.20324006 | -0.335156108 | 1.212 | 1.243 | C | 1 |
3358 | N | ASN | 99.91163476 | 1.438145364 | 1.249 | 1.021 | T | 1 |
3359 | P | PRO | 42.50368189 | -0.211575194 | 1.413 | 1.415 | T | 0 |
3360 | K | LYS | 10.04418262 | -1.144357162 | 3.427 | 2.875 | T | 0 |
3361 | T | THR | 99.91163476 | 1.438145364 | 2.486 | 1.163 | T | 0 |
3362 | P | PRO | 99.94108984 | 1.438991809 | 2.56 | 1.086 | C | 0 |
3363 | K | LYS | 59.05743741 | 0.264126681 | 2.5 | 1.607 | E | 1 |
3364 | Y | TYR | 86.80412371 | 1.06147751 | 2.107 | 1.071 | E | 2 |
3365 | K | LYS | 34.37407953 | -0.445193908 | 1.927 | 1.498 | E | 2 |
3366 | F | PHE | 81.8556701 | 0.919274814 | 1.729 | 1.302 | E | 2 |
3367 | V | VAL | 17.23122239 | -0.937824675 | 1.8 | 1.439 | E | 1 |
3368 | R | ARG | 13.69661267 | -1.039398029 | 1.825 | 1.362 | C | 0 |
3369 | I | ILE | 11.7820324 | -1.094416929 | 1.585 | 1.133 | C | 1 |
3370 | Q | GLN | 12.66568483 | -1.069023591 | 1.396 | 1.397 | T | 1 |
3371 | P | PRO | 75.11045655 | 0.725438997 | 1.223 | 1.104 | T | 0 |
3372 | G | GLY | 99.88217968 | 1.437298919 | 1.179 | 1.03 | T | 1 |
3373 | Q | GLN | 9.837997054 | -1.150282274 | 1.344 | 1.453 | E | 1 |
3374 | T | THR | 23.44624448 | -0.759224861 | 1.545 | 1.281 | E | 0 |
3375 | F | PHE | 95.46391753 | 1.310332227 | 1.216 | 0.794 | E | 0 |
3376 | S | SER | 33.60824742 | -0.467201468 | 1.085 | 0.849 | E | 0 |
3377 | V | VAL | 46.48011782 | -0.097305171 | 0.93 | 1.168 | E | 0 |
3378 | L | LEU | 80.29455081 | 0.874413249 | 1.171 | 1.176 | E | 0 |
3379 | A | ALA | 79.85272459 | 0.86171658 | 1.274 | 0.881 | E | 0 |
3380 | C | CYS | 66.15611193 | 0.468119833 | 1.561 | 0.924 | E | 0 |
3381 | Y | TYR | 99.94108984 | 1.438991809 | 1.536 | 0.837 | E | 0 |
3382 | N | ASN | 47.06921944 | -0.080376279 | 1.878 | 1.468 | T | 0 |
3383 | G | GLY | 99.88217968 | 1.437298919 | 1.638 | 1.073 | T | 0 |
3384 | S | SER | 21.97349043 | -0.801547092 | 1.91 | 0.976 | E | 0 |
3385 | P | PRO | 55.28718704 | 0.15578177 | 1.72 | 0.917 | E | 0 |
3386 | S | SER | 14.34462445 | -1.020776248 | 2.013 | 0.944 | E | 0 |
3387 | G | GLY | 90.86892489 | 1.178286867 | 1.299 | 0.731 | E | 0 |
3388 | V | VAL | 47.7466863 | -0.060908052 | 1.094 | 0.92 | E | 0 |
3389 | Y | TYR | 56.75994109 | 0.198104 | 0.932 | 0.817 | E | 0 |
3390 | Q | GLN | 9.307805596 | -1.165518277 | 1.139 | 1.132 | E | 0 |
3391 | C | CYS | 9.896907216 | -1.148589385 | 1.187 | 0.945 | E | 0 |
3392 | A | ALA | 9.366715758 | -1.163825388 | 0.901 | 0.952 | E | 0 |
3393 | M | MET | 88.24742268 | 1.102953296 | 0.659 | 0.972 | C | 0 |
3394 | R | ARG | 95.93519882 | 1.323875341 | 0.759 | 0.747 | T | 0 |
3395 | P | PRO | 32.04712813 | -0.512063033 | 1.121 | 0.924 | T | 0 |
3396 | N | ASN | 79.20471281 | 0.843094798 | 0.837 | 0.79 | T | 0 |
3397 | F | PHE | 5.449189985 | -1.276402522 | 0.786 | 0.954 | T | 0 |
3398 | T | THR | 95.90574374 | 1.323028896 | 0.795 | 0.813 | C | 0 |
3399 | I | ILE | 98.52724595 | 1.398362467 | 0.831 | 0.87 | C | 0 |
3400 | K | LYS | 57.58468336 | 0.22180445 | 0.993 | 1.082 | C | 0 |
3401 | G | GLY | 79.97054492 | 0.865102358 | 1.255 | 0.833 | T | 0 |
3402 | S | SER | 99.76435935 | 1.433913141 | 1.32 | 0.993 | T | 0 |
3403 | F | PHE | 99.82326951 | 1.43560603 | 1.195 | 1.204 | T | 0 |
3404 | L | LEU | 66.3622975 | 0.474044945 | 1.07 | 0.874 | T | 0 |
3405 | N | ASN | 39.82326951 | -0.288601654 | 2.258 | 1.179 | C | 0 |
3406 | G | GLY | 99.82326951 | 1.43560603 | 3.899 | 0.991 | C | 0 |
3407 | S | SER | 47.86450663 | -0.057522274 | 3.378 | 0.754 | C | 0 |
3408 | C | CYS | 99.67599411 | 1.431373807 | 1.108 | 0.689 | C | 0 |
3409 | G | GLY | 99.88217968 | 1.437298919 | 1.107 | 0.557 | E | 0 |
3410 | S | SER | 99.76435935 | 1.433913141 | 1.82 | 0.812 | E | 0 |
3411 | V | VAL | 68.86597938 | 0.545992738 | 1.455 | 1.174 | E | 0 |
3412 | G | GLY | 99.70544919 | 1.432220252 | 1.081 | 0.615 | E | 0 |
3413 | F | PHE | 26.9808542 | -0.657651507 | 1.167 | 0.897 | E | 0 |
3414 | N | ASN | 50.25036819 | 0.01103974 | 2.025 | 1.258 | E | 1 |
3415 | I | ILE | 34.87481591 | -0.43080435 | 2.802 | 1.724 | E | 2 |
3416 | D | ASP | 9.513991163 | -1.159593165 | 3.019 | 1.819 | E | 2 |
3417 | Y | TYR | 9.307805596 | -1.165518277 | 3.945 | 3.06 | T | 2 |
3418 | D | ASP | 26.68630339 | -0.666115953 | 3.887 | 1.95 | T | 1 |
3419 | C | CYS | 19.85272459 | -0.862491104 | 2.463 | 1.455 | E | 1 |
3420 | V | VAL | 67.09867452 | 0.495206061 | 2.112 | 1.41 | E | 1 |
3421 | S | SER | 9.337260677 | -1.164671833 | 1.692 | 1.106 | E | 0 |
3422 | F | PHE | 95.75846834 | 1.318796673 | 1.295 | 0.805 | E | 0 |
3423 | C | CYS | 55.43446244 | 0.160013993 | 1.146 | 1.005 | E | 0 |
3424 | Y | TYR | 99.76435935 | 1.433913141 | 1.08 | 0.753 | E | 0 |
3425 | M | MET | 77.34904271 | 0.789768788 | 0.961 | 0.886 | E | 0 |
3426 | H | HIS | 99.70544919 | 1.432220252 | 0.681 | 0.64 | E | 0 |
3427 | H | HIS | 35.8173785 | -0.403718122 | 0.694 | 0.839 | E | 0 |
3428 | M | MET | 33.10751105 | -0.481591027 | 0.834 | 1.185 | E | 0 |
3429 | E | GLU | 99.73490427 | 1.433066696 | 1.092 | 1.093 | E | 0 |
3430 | L | LEU | 95.61119293 | 1.31456445 | 1.081 | 1.113 | E | 1 |
3431 | P | PRO | 25.68483063 | -0.69489507 | 1.527 | 1.313 | T | 1 |
3432 | T | THR | 23.06332842 | -0.770228641 | 1.272 | 1.175 | T | 0 |
3433 | G | GLY | 78.70397644 | 0.82870524 | 1.462 | 1.17 | E | 0 |
3434 | V | VAL | 9.837997054 | -1.150282274 | 0.925 | 1.182 | E | 0 |
3435 | H | HIS | 99.61708395 | 1.429680918 | 1.008 | 0.91 | E | 0 |
3436 | A | ALA | 9.307805596 | -1.165518277 | 0.773 | 0.822 | E | 0 |
3437 | G | GLY | 99.76435935 | 1.433913141 | 0.682 | 0.651 | E | 0 |
3438 | T | THR | 43.00441826 | -0.197185636 | 0.856 | 0.789 | E | 0 |
3439 | D | ASP | 66.5095729 | 0.478277169 | 1.429 | 0.904 | E | 0 |
3440 | L | LEU | 49.95581738 | 0.002575294 | 1.659 | 1.346 | T | 0 |
3441 | E | GLU | 18.79234168 | -0.892963111 | 1.86 | 1.547 | T | 0 |
3442 | G | GLY | 99.67599411 | 1.431373807 | 1.557 | 0.898 | E | 0 |
3443 | N | ASN | 11.34020619 | -1.107113599 | 1.458 | 1.248 | E | 1 |
3444 | F | PHE | 43.29896907 | -0.188721189 | 1.109 | 0.965 | E | 1 |
3445 | Y | TYR | 99.76435935 | 1.433913141 | 0.824 | 0.789 | C | 0 |
3446 | G | GLY | 99.76435935 | 1.433913141 | 0.859 | 0.852 | C | 0 |
3447 | P | PRO | 27.33431517 | -0.647494172 | 1.482 | 1.072 | C | 0 |
3448 | F | PHE | 41.91458027 | -0.228504086 | 1.293 | 0.909 | C | 0 |
3449 | V | VAL | 22.68041237 | -0.781232421 | 1.538 | 1.381 | C | 0 |
3450 | D | ASP | 99.79381443 | 1.434759586 | 2.069 | 1.246 | C | 0 |
3451 | R | ARG | 10.51546392 | -1.130814048 | 2.759 | 2.387 | C | 0 |
3452 | Q | GLN | 46.95139912 | -0.083762057 | 2.38 | 2.342 | C | 1 |
3453 | T | THR | 28.42415317 | -0.616175721 | 2.182 | 2.005 | C | 2 |
3454 | A | ALA | 25.24300442 | -0.70759174 | 2.271 | 1.919 | C | 1 |
3455 | Q | GLN | 99.82326951 | 1.43560603 | 1.969 | 1.113 | C | 0 |
3456 | A | ALA | 9.985272459 | -1.146050051 | 1.539 | 1.217 | T | 0 |
3457 | A | ALA | 10.04418262 | -1.144357162 | 2.189 | 1.502 | T | 0 |
3458 | G | GLY | 36.4359352 | -0.385942785 | 1.873 | 1.432 | T | 0 |
3459 | T | THR | 37.0544919 | -0.368167448 | 1.32 | 1.053 | T | 0 |
3460 | D | ASP | 63.15169367 | 0.381782482 | 1.09 | 1.357 | C | 0 |
3461 | T | THR | 10.63328424 | -1.12742827 | 1.435 | 1.216 | C | 0 |
3462 | T | THR | 11.19293078 | -1.111345822 | 2.143 | 1.052 | E | 0 |
3463 | I | ILE | 12.51840943 | -1.073255814 | 2.514 | 1.3 | H | 1 |
3464 | T | THR | 58.61561119 | 0.251430011 | 2.42 | 0.94 | H | 1 |
3465 | V | VAL | 41.97349043 | -0.226811197 | 2.61 | 1.094 | H | 1 |
3466 | N | ASN | 99.79381443 | 1.434759586 | 2.53 | 0.761 | H | 1 |
3467 | V | VAL | 72.78350515 | 0.658569872 | 1.982 | 0.905 | H | 0 |
3468 | L | LEU | 38.35051546 | -0.330923885 | 1.897 | 0.979 | H | 0 |
3469 | A | ALA | 98.40942563 | 1.394976689 | 2.199 | 0.868 | H | 0 |
3470 | W | TRP | 63.91752577 | 0.403790042 | 2.041 | 0.895 | H | 0 |
3471 | L | LEU | 97.93814433 | 1.381433575 | 1.697 | 0.872 | H | 0 |
3472 | Y | TYR | 99.64653903 | 1.430527362 | 2.145 | 0.772 | H | 1 |
3473 | A | ALA | 96.78939617 | 1.348422235 | 2.576 | 0.946 | H | 1 |
3474 | A | ALA | 95.69955817 | 1.317103784 | 2.221 | 0.928 | H | 1 |
3475 | V | VAL | 10.81001473 | -1.122349602 | 2.518 | 1.104 | H | 2 |
3476 | I | ILE | 49.83799705 | -0.000810485 | 3.213 | 1.218 | H | 2 |
3477 | N | ASN | 79.67599411 | 0.856637912 | 3.526 | 1.259 | H | 1 |
3478 | G | GLY | 66.39175258 | 0.47489139 | 3.353 | 1.211 | C | 0 |
3479 | D | ASP | 14.28571429 | -1.022469137 | 2.641 | 1.185 | C | 0 |
3480 | R | ARG | 20.14727541 | -0.854026658 | 3.021 | 1.851 | T | 0 |
3481 | W | TRP | 79.97054492 | 0.865102358 | 3.005 | 1.437 | T | 0 |
3482 | F | PHE | 52.90132548 | 0.087219756 | 2.004 | 0.99 | T | 0 |
3483 | L | LEU | 54.78645066 | 0.141392211 | 1.688 | 1.17 | T | 0 |
3484 | N | ASN | 9.867452135 | -1.14943583 | 1.39 | 1.694 | C | 0 |
3485 | R | ARG | 9.337260677 | -1.164671833 | 1.926 | 2.824 | C | 0 |
3486 | F | PHE | 9.307805596 | -1.165518277 | 2.024 | 2.398 | C | 0 |
3487 | T | THR | 24.62444772 | -0.725367077 | 2.244 | 1.61 | C | 1 |
3488 | T | THR | 32.54786451 | -0.497673475 | 2.235 | 1.368 | C | 2 |
3489 | T | THR | 13.40206186 | -1.047862476 | 2.347 | 1.42 | H | 2 |
3490 | L | LEU | 17.82032401 | -0.920895783 | 2.719 | 1.599 | H | 2 |
3491 | N | ASN | 9.572901325 | -1.157900276 | 3.14 | 1.84 | H | 2 |
3492 | D | ASP | 41.11929308 | -0.251358091 | 2.794 | 1.517 | H | 2 |
3493 | F | PHE | 73.54933726 | 0.680577432 | 2.425 | 1.346 | H | 2 |
3494 | N | ASN | 99.76435935 | 1.433913141 | 2.843 | 1.348 | H | 2 |
3495 | L | LEU | 9.307805596 | -1.165518277 | 3.064 | 2.148 | H | 1 |
3496 | V | VAL | 9.307805596 | -1.165518277 | 2.516 | 1.912 | H | 0 |
3497 | A | ALA | 98.910162 | 1.409366247 | 2.521 | 1.351 | H | 0 |
3498 | M | MET | 16.34756996 | -0.963218014 | 3.241 | 2.437 | H | 1 |
3499 | K | LYS | 9.926362297 | -1.14774294 | 2.892 | 2.46 | H | 1 |
3500 | Y | TYR | 10.0736377 | -1.143510717 | 1.986 | 1.693 | C | 0 |
3501 | N | ASN | 9.837997054 | -1.150282274 | 3.143 | 1.957 | E | 0 |
3502 | Y | TYR | 13.10751105 | -1.056326922 | 2.55 | 1.267 | E | 1 |
3503 | E | GLU | 9.337260677 | -1.164671833 | 2.431 | 1.267 | E | 1 |
3504 | P | PRO | 19.23416789 | -0.880266441 | 2.552 | 1.223 | C | 0 |
3505 | L | LEU | 14.93372607 | -1.003847355 | 2.841 | 1.518 | C | 0 |
3506 | T | THR | 10.30927835 | -1.13673916 | 3.472 | 1.351 | H | 1 |
3507 | Q | GLN | 9.307805596 | -1.165518277 | 3.821 | 1.965 | H | 2 |
3508 | D | ASP | 9.602356406 | -1.157053831 | 4.251 | 1.489 | H | 2 |
3509 | H | HIS | 9.278350515 | -1.166364722 | 3.367 | 1.1 | H | 2 |
3510 | V | VAL | 9.307805596 | -1.165518277 | 2.929 | 1.23 | H | 2 |
3511 | D | ASP | 39.02798233 | -0.311455659 | 3.632 | 1.431 | H | 2 |
3512 | I | ILE | 9.189985272 | -1.168904056 | 3.416 | 1.359 | H | 2 |
3513 | L | LEU | 13.75552283 | -1.03770514 | 3.041 | 0.991 | H | 2 |
3514 | G | GLY | 9.572901325 | -1.157900276 | 3.347 | 1.038 | H | 2 |
3515 | P | PRO | 9.985272459 | -1.146050051 | 3.685 | 1.221 | H | 2 |
3516 | L | LEU | 98.61561119 | 1.400901801 | 3.041 | 1.137 | H | 2 |
3517 | S | SER | 28.77761414 | -0.606018386 | 2.432 | 1.058 | H | 2 |
3518 | A | ALA | 58.17378498 | 0.238733342 | 3.029 | 1.353 | H | 2 |
3519 | Q | GLN | 9.13107511 | -1.170596945 | 3.359 | 1.598 | H | 2 |
3520 | T | THR | 96.08247423 | 1.328107564 | 2.697 | 1.178 | H | 2 |
3521 | G | GLY | 95.31664212 | 1.306100004 | 2.213 | 1.179 | H | 2 |
3522 | I | ILE | 10.19145803 | -1.140124939 | 1.541 | 1.285 | C | 1 |
3523 | A | ALA | 30.95729013 | -0.543381484 | 1.544 | 1.104 | H | 0 |
3524 | V | VAL | 64.88954345 | 0.431722715 | 1.765 | 1.049 | H | 0 |
3525 | L | LEU | 9.307805596 | -1.165518277 | 1.685 | 1.205 | H | 0 |
3526 | D | ASP | 9.248895434 | -1.167211167 | 1.473 | 0.964 | H | 1 |
3527 | M | MET | 10.81001473 | -1.122349602 | 1.421 | 0.869 | H | 1 |
3528 | C | CYS | 9.366715758 | -1.163825388 | 1.679 | 0.849 | H | 1 |
3529 | A | ALA | 46.65684831 | -0.092226503 | 1.667 | 1.096 | H | 2 |
3530 | S | SER | 25.24300442 | -0.70759174 | 1.468 | 1.018 | H | 1 |
3531 | L | LEU | 10.0736377 | -1.143510717 | 1.464 | 1.2 | H | 1 |
3532 | K | LYS | 23.97643594 | -0.743988858 | 2.106 | 1.695 | H | 1 |
3533 | E | GLU | 8.483063328 | -1.189218727 | 2.335 | 1.551 | H | 1 |
3534 | L | LEU | 83.4167894 | 0.964136379 | 2.236 | 1.768 | H | 2 |
3535 | L | LEU | 9.955817378 | -1.146896496 | 2.454 | 1.844 | H | 2 |
3536 | Q | GLN | 10.04418262 | -1.144357162 | 4.078 | 2.773 | H | 1 |
3537 | N | ASN | 9.307805596 | -1.165518277 | 4.257 | 1.971 | H | 0 |
3538 | G | GLY | 61.50220913 | 0.334381584 | 2.701 | 1.322 | C | 0 |
3539 | M | MET | 9.337260677 | -1.164671833 | 2.399 | 1.667 | C | 0 |
3540 | N | ASN | 9.602356406 | -1.157053831 | 2.038 | 1.252 | C | 0 |
3541 | G | GLY | 83.65243004 | 0.970907936 | 1.297 | 0.844 | C | 0 |
3542 | R | ARG | 28.27687776 | -0.620407944 | 1.928 | 1.258 | C | 0 |
3543 | T | THR | 18.05596465 | -0.914124226 | 2.555 | 1.156 | C | 0 |
3544 | I | ILE | 98.85125184 | 1.407673358 | 1.986 | 1.028 | T | 0 |
3545 | L | LEU | 84.53608247 | 0.996301274 | 2.307 | 1.095 | T | 0 |
3546 | G | GLY | 94.49189985 | 1.282399555 | 2.301 | 0.913 | T | 0 |
3547 | S | SER | 49.66126657 | -0.005889152 | 2.368 | 1.155 | T | 0 |
3548 | A | ALA | 3.858615611 | -1.322110531 | 3.498 | 0.955 | C | 0 |
3549 | L | LEU | 1.973490427 | -1.376282987 | 1.994 | 1.882 | C | 0 |
3550 | L | LEU | 67.77614138 | 0.514674287 | 1.256 | 1.295 | C | 0 |
3551 | E | GLU | 65.94992636 | 0.462194721 | 1.398 | 1.235 | C | 0 |
3552 | D | ASP | 95.75846834 | 1.318796673 | 2.068 | 0.777 | C | 0 |
3553 | E | GLU | 95.61119293 | 1.31456445 | 2.781 | 1.007 | C | 0 |
3554 | F | PHE | 63.97643594 | 0.405482932 | 3.597 | 0.921 | C | 0 |
3555 | T | THR | 94.69808542 | 1.288324667 | 4.005 | 1.038 | H | 0 |
3556 | P | PRO | 71.7820324 | 0.629790755 | 3.89 | 0.955 | H | 1 |
3557 | F | PHE | 9.42562592 | -1.162132499 | 4.177 | 1.429 | H | 2 |
3558 | D | ASP | 46.92194404 | -0.084608502 | 4.067 | 1.032 | H | 2 |
3559 | V | VAL | 98.26215022 | 1.390744465 | 3.463 | 1.123 | H | 2 |
3560 | V | VAL | 19.76435935 | -0.865030438 | 3.883 | 1.387 | H | 2 |
3561 | R | ARG | 33.46097202 | -0.471433691 | 4.287 | 2.063 | H | 2 |
3562 | Q | GLN | 99.41089838 | 1.423755806 | 4.082 | 1.374 | H | 2 |
3563 | C | CYS | 9.42562592 | -1.162132499 | 5.552 | 1.593 | C | 1 |
3564 | S | SER | 9.661266568 | -1.155360942 | 6.528 | 1.983 | C | 0 |
3565 | G | GLY | 95.58173785 | 1.313718005 | 5.316 | 1.752 | C | 0 |
3566 | V | VAL | 84.74226804 | 1.002226386 | 6.578 | 2.566 | C | 0 |
3567 | T | THR | 10.98674521 | -1.117270934 | 8.7 | 4.059 | C | 1 |
3568 | F | PHE | 8.983799705 | -1.174829168 | 11.571 | 5.853 | C | 2 |
3569 | Q | GLN | 94.81590574 | 1.291710445 | 12.904 | 6.502 | C | 1 |
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