PubMed

ResearchGate

Highlighted Papers

Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J. Whole genome sequencing in the clinic: The past, present, and future of genomic medicine. Physiological Genomics. Accepted (2018). PMID:29727589

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy L, Meijer FA, Geurts AM, Rauscher FJ, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J. Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD. Journal of the American Society of Nephrology. 29(5):1525-1535 (2018). PMID: 29476007

Prokop JW, Lazar J, Crapitto G, Smith DC, Worthey EA, Jacob HJ. Molecular modeling in the age of clinical genomics, the enterprise of the next generation. Journal of Molecular Modeling. 23: 75 (2017). PMID 28204942

Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ. The Phenotypic Impact of the Male Specific Region of Chromosome-Y in Inbred Mating: The role of genetic variants and gene duplications in multiple inbred rat strains. Biology of Sex Differences, 7:10 (2016). PMID: 26848384.

Prokop JW, Deschepper CF. Chromosome Y genetic variants: impact in animal models and on human disease. Physiological Genomics, 47(11):525-537 (2015). PMID: 26286457.

All Publications

Hiatt SM, Neu MB, Hardigan A, Ramaker R, Prokop JW, Prchal J, Hancarova M, Prchalova D, Havlovicova M, Stranecky V, Yim D, Powis Z, Keren B, Nava C, Mignot C, Rio M, Revah-Politi A, Hemati P, Strong N, Iglesias AD, Suchy S, Willaert R, Wentzensen IM, Wheeler PG. Hurst ACE, Wheless JW, Lacassie Y, Sedlacek Z, Cooper GM. Variation in RALA is associated with a novel neurodevelopmental disorder. PLOS Genetics. Status: Minor Revisions, pre-released to Biorxiv.

Seaver LH, DeRoss S, Anderson NJ, Betz B, Prokop JW, Lannen N, Jordan R, Rajasekaran S. Lethal NARS2-related disorder associated rapidly progressive intractable epilepsy and global brain atrophy. Pediatric Neurology. Accepted (2018).

Blok LS, Hiatt SM, Bowling KM, Prokop JW, Engel KL, Cochran JN, Bebin EM, Bijlsma E, Terhal P, Smith R, Hurst J, Cho M, Wangler M, Streff H, Symonds J, Zuberi S, Sanders V, Simon M, Pfundt R, Brunner HG, Fisher SE, Kleefstra T, Cooper GM. De novo mutations in MED13, a component of the Mediator complex, cause a new neurodevelopmental disorder. Human Genetics. Accepted (2018). PMID: 29740699

Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J. Whole genome sequencing in the clinic: The past, present, and future of genomic medicine. Physiological Genomics. Accepted (2018). PMID:29727589 https://www.physiology.org/doi/abs/10.1152/physiolgenomics.00046.2018

Fontaine F, Foodall S, Prokop J, Howard C, Moustaqil M, Kumble S, Rasicci S, Osborne G, Gambin Y, Sierecki E, Jones M, Zuegg J, Mahler S, Francois M. Functional domain analysis of SOX18 transcription factor using a scFv-fragment based approach. mAbs. In Press (2018). PMID:29648920

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy L, Meijer FA, Geurts AM, Rauscher FJ, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J. Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD. Journal of the American Society of Nephrology. 29(5):1525-1535 (2018). PMID: 29476007

Peng H, Prokop J, Karar J, Park K, Cao L, Harbour J, Bowcock AM, Malkowicz SB, Cheung M, Testa JR, Rauscher FJ III. Familial and somatic BAP1 mutations inactivate ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase by Targeting multiple independent domains. Cancer Research. 78(5):1200-1213 (2018). PMID: 29284740

Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A, Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg-Woods LC. Genetic fine-mapping and identification of candidate genes and variants for adiposity traits in outbred rats. Obesity. 26(1):213-222 (2018). PMID 29193816

Schilter K, Steiner J, Demos W, Maheshawri M, Prokop JW, Worthey E, Drolet B, Siegel DH. RNF213 variants in a child with Segmental Hemangioma Syndrome and Motamoya Vasculopathy. American Journal of Medical Genetics: Part A. 173(9):2557-2561 (2017). PMID 28686325

Londraville RL, Prokop JW, Liu Q, Duff RJ, Tuttle M. On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin. Frontiers in Endocrinology. 8:58 (2017). PMID 28443063

Prokop JW, Lazar J, Crapitto G, Smith DC, Worthey EA, Jacob HJ. Molecular modeling in the age of clinical genomics, the enterprise of the next generation. Journal of Molecular Modeling. 23: 75 (2017). PMID 28204942

Cramer JM, Pohlman D, Gomez F, Mark L, Lornegay B, Hall C, Buchwald WA, Walavalkar NM, Bilinovich SM, Prokop JW, Hill AL, Williams Jr DC. Methylation specific targeting of a chromatin remodeling complex from sponges to humans. Scientific Reports. 7:40674 (2017). PMID: 28094816

Ball  HC, Londraville RL, Prokop JW, George JC, Suydam R, Thewissen JGM, Duff RJ. Beyond Thermoregulation: Metabolic Function of Cetacean Blubber in Migrating Bowhead and Beluga Whales. Journal of Comparative Physiology B. 187:235-252 (2017). PMID: 27573204.

Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL. Differences in the phosphorylation-dependent regulation of prenylation of Rap1A and Rap1B. Journal of Molecular Biology. 428:4929-4945 (2016). PMID: 27760305.

Moller RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Beben EM, Hiatt SM, Prokop JW, Bowling KM, Mei D, Conti V, Frange P, Ferrand-Sorbets S, Dorgmuller G, Lambrecq V, Larsen LHG, Leguern E, Guerrini R, Rubboli G, Cooper GM, Baulac S. Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy. Neurology: Genetics, 2:e118 (2016). PMID 27830187.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The tumor suppressive small GTPase DiRas1 binds the non-canonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. Journal of Biological Chemistry, 291(12):6534-6545 (2016). PMID: 27197236.

Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ. The Phenotypic Impact of the Male Specific Region of Chromosome-Y in Inbred Mating: The role of genetic variants and gene duplications in multiple inbred rat strains. Biology of Sex Differences, 7:10 (2016). PMID: 26848384.

Prokop JW, Deschepper CF. Chromosome Y genetic variants: impact in animal models and on human disease. Physiological Genomics, 47(11):525-537 (2015). PMID: 26286457.

Flister MJ, Prokop JW, Dwinell M, Lazar J, Geurts A. 2015 Guildelines for Establishing Rat Transgenic Models for Cardiovascular Research. Journal of Cardiovascular Translational Research, 8(4):269-277 (2015). PMID: 25920443.

Prokop JW, Petri V, Shimoyama ME, Watanabe IKM, Caserini DE, Leeper TC, Bilinovich SM, Jacob HJ, Santos RA, Martins AS, Araujo FC, Reis FM, Milsted A. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system. General and Comparative Endocrinology, 215:106-116 (2015). PMID: 25260253

Araujo FC, Milsted A, Watanabe IKM, Del Puerto HL, Santos RAS, Lazar J, Reis FM, Prokop JW. Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. Physiological Genomics, 47:177-186 (2015). PMID: 25759379

Rudemiller NP, Lund H, Priestley JR, Prokop JW, Jacob HJ, Geurts AM, Mattson DL.  Mutation of SH2B3 (LNK), a GWAS candidate for hypertension, attenuates Dahl SS hypertension via inflammatory modulation. Hypertension, 65:1111-1117 (2015). PMID: 25776069

Chang AT, Liu Y, Ayyanathan K, Benner C, Jiang Y, Prokop JW, Paz H, Wang D, Li H, Fu X, Rauscher FJ, Yang J. An evolutionarily conserved DNA architecture determines target specificity of Twist family bHLH transcription factors. Genes and Development, 29:603-616 (2015). PMID: 25762439.

Prisco SZ, Prokop JW, Sarkis AB, Yeo NC, Hoffman MJ, Hansen CC, Jacob HJ, Flister MJ, Lazar J. Refined mapping of a hypertension susceptibility locus on rat chromosome 12. Hypertension, 64:883-890 (2014). PMID: 25001272.

Prokop JW, Schmidt C, Gasper D, Duff RJ, Milsted A, Ohkubo T, Ball HC, Shawkey MD, Mays Jr HL, Cogburn LA, Londraville RL. Discovery of the elusive leptin in birds: Identification of several ‘missing links’ in the evolution of leptin and its receptor. PLOS One, 9:e92751 (2014). PMID: 24663438.

Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC. The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region. Journal of Molecular Biology, 426:1753-1765 (2014). PMID: 24486611

Peng H, Farrooji MTZ, Hou Z, Prokop JW, Osborne MJ, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Speicher D, Skordalakes E, Borden KLB, Rauscher FJ III. LIMD2 is a small LIM-only protein which regulates cell motility and is a novel effector of tumor progression: Structural analysis suggests a role in the integrin-linked-kinase (ILK) pathway. Cancer Research, 74:1390 (2014). PMID: 24590809

Dores RM, Londraville R, Prokop J, Davis P, Dewey N, Lisinski N. MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors. Journal of Molecular Endocrinology, 52:T29-T42 (2014). PMID: 24868105.

Prokop JW, Rauscher FJ III, Peng H, Liu Y, Araujo FC, Watanabe I, Reis FM, Milsted A. MAS promoter regulation: A role of Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism. Clinical Science, 126(10):727-738 (2014). PMID: 24128372

Prokop JW, Milsted A, Liu Y, Peng H, Rauscher FJ III. A method for in silico localization of DNA binding sites for transcription factors using molecular dynamics and evolutionarily conserved amino acids: Application to the SNAIL/SLUG E-box binding zinc finger family. Journal of Molecular Modeling, 19(9):3463-3469 (2013). PMID: 23708613

Prokop JW, Santos RAS, Milsted A. Differential mechanisms of activation of the Ang peptide receptors AT1, AT2, and MAS: Using in silico techniques to differentiate the three receptors. PLoS One, 8(6):e65307 (2013). PMID: 23755216

Prokop JW, Underwood AC, Turner ME, Miller N, Pietrzak D, Scott S, Smith C, Milsted A. Analysis of Sry duplications on the Rattus norvegicus Y-chromosome. BMC Genomics, 14:792 (2013). PMID: 24228692

Prokop JW, Watanabe IKM, Turner ME, Underwood AC, Martins AS, Milsted A. From rat to human, regulation of renin-angiotensin system genes by Sry. International Journal of Hypertension, 2012: 724240 (2012). PMID: 22315667

Prokop JW, Duff RJ, Ball HC, Copeland DL, Londraville RL. Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides, 38(2):326-36 (2012). PMID: 23085324

Prokop JW, Leeper T, Duan ZH, Milsted A.  Amino acid function and docking site prediction through combining disease variants, structure alignments, sequence alignments, and molecular dynamics: A study of the HMG domain. BMC Bioinformatics, 13 (Suppl 2):S3 (2012). PMID: 22536866

Turner ME, Ely D, Prokop J, Milsted A. Sry, more than testis determination? American Journal of Physiology- Regulatory, Integrative and Comparative Physiology, 301(3):R561-571 (2011). PMID: 21677270

Copeland DL, Duff RJ, Liu Q, Prokop J, Londraville RL. Leptin in Teleost Fishes: An Argument for Comparative Study. Frontiers in Physiology. 2:26 (2011). PMID: 21716655