Genes and Variants to Function
The lab focuses on developing a knowledge of either genes or variants to functional outcomes in cells and organisms for the broad understanding of life and the details of how multiple diseases develop. The lab starts with computational analysis to build working hypotheses that are then tested using biochemical, cellular, and organism methods.
The lab has developed a workflow for a sequence-to-structure-to-function-to-phenotype understanding of genes that uses a combination of evolutionary biology, structural chemistry, and expression profiling.
Using multiple biochemical techniques we then test hypotheses for protein-protein and protein-DNA interaction
The detailed knowledge of protein function is then translated into cellular mechanisms using a variety of cell culture techniques
With various collaborators we finally develop and test our hypotheses in animal models