Leptin Evolution

Our initial study into metabolism was to develop a working view of leptin evolution from a structure level.

Deep evolutionary analysis of the leptin receptor identified functional sites.
Deep evolutionary analysis of the leptin receptor identified functional sites.
Leptin dimer formation
Leptin dimer formation

Bird Leptin

This work led us to discover the first authentic avian Leptin gene.

Mapping the bird leptin gene and its human synteny

Invertebrate Leptin System

Further we have gone into the origins of leptin signalling, including mapping the role of the leptin receptor overlapping gene.

Invertebrate leptin and leptin receptor proteins
Invertebrate leptin and leptin receptor proteins